? Release performance and sustained-release efficacy of emamectin benzoate-loaded polylactic acid microspheres
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    2018, Vol. 17 Issue (03): 640-647     DOI: 10.1016/S2095-3119(17)61763-5
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Release performance and sustained-release efficacy of emamectin benzoate-loaded polylactic acid microspheres
YIN Ming-ming, ZHU Xin-yan, CHEN Fu-liang  
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China
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Abstract High-performance liquid chromatography (HPLC) was employed to determine drug release rates based on emamectin benzoate concentrations in the medium.  Release kinetics equations were used to fit the drug release behavior.  The effects of particle size and release medium pH on the release rate were also investigated.  The indoor toxicity of emamectin benzoate-loaded polylactic acid microspheres on the diamondback moth larva (Plutella xylostella) was studied to explore drug sustained-release performance.  In acidic and neutral media, the drug release behavior of the microspheres was in accord with the first-order kinetics equation.  Increasing the spray dosage of emamectin benzoate-loaded polylactic acid microspheres initially resulted in an equivalent insecticidal efficacy with the conventional emamectin benzoate microemulsion.  However, the drug persistence period was four-fold longer than that observed using the conventional formulation.  The developed emamectin benzoate-loaded polylactic acid microspheres showed dramatic sustained-release performance.  A treatment threshold of greater than 35 mg mL–1 was established for an efficient accumulated release concentration of emamectin benzoate-loaded microspheres.
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Key wordsemamectin benzoate     polylactic acid microspheres     release performance     kinetics equation     sustained-release efficacy     
Received: 2017-05-24; Published: 2017-08-09

The study was supported by the National Key Research and Development Program of China (2016YFD0200502, 2017YFD0200301).

Corresponding Authors: Correspondence CHEN Fu-liang, E-mail: flchen@ippcaas.cn   
About author: YIN Ming-ming, E-mail: mmyin@ippcaas.cn;
Cite this article:   
YIN Ming-ming, ZHU Xin-yan, CHEN Fu-liang. Release performance and sustained-release efficacy of emamectin benzoate-loaded polylactic acid microspheres[J]. Journal of Integrative Agriculture, 2018, 17(03): 640-647.
http://www.chinaagrisci.com/Jwk_zgnykxen/EN/ 10.1016/S2095-3119(17)61763-5      or     http://www.chinaagrisci.com/Jwk_zgnykxen/EN/Y2018/V17/I03/640
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