Pesticide residues in bayberry (Myrica rubra) and probabilistic risk assessment for consumers in Zhejiang, China
YANG Gui-ling1, 2, WANG Wen2, LIANG Sen-miao2, YU Yi-jun3, ZHAO Hui-yu2, WANG Qiang2, QIAN Yong-zhong1
1 Key Laboratory of Agro-Product Quality and Safety, Ministry of Agriculture/Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R.China 2 Laboratory of Quality & Safety Risk Assessment for Agro-Products (Hangzhou)/Key Laboratory for Pesticide Residue Detection, Ministry of Agriculture/Institute of Quality and Standards for Agricultural Products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, P.R.China 3 Zhejiang Bureau for Agriculture, Hangzhou 310021, P.R.China
Abstract As pesticide residues in bayberry has raised serious concern from the public in China, a monitoring survey was carried out during 2013–2014 and 157 samples were analyzed in total. Twenty-three pesticides were detected among the 44 pesticides analyzed and at least one pesticide was detected in 63% of 99 samples. Whereas 45.6% of samples were found with two or more pesticide residues, and 23.6% of samples with four or more pesticide residues. Probabilistic risk assessments indicated that estimated daily intake (EDI) of cyhalothrin at the P97.5th percentile level is 1.11 times larger than the acceptable daily intake (ADI) for children, the estimated short-term intake (ESTI) at the P97.5th percentile level is 1.9 and 1.78 times larger than the acute reference dose (ARfD) for adult and children, respectively, indicating the potential risk concern from pyrethroids. EDI of the pesticides with anti-androgenic effects ranged from 0.15–2.46 of ADI, the probability of exposure exceeding the ADI was 7.1 and 31.1% for adults and children, respectively, the probability of exposure of pyrethroids exceeding the ADI was 3.8% for children. Exposures for other pesticides and groups were below 1.0. Because the co-occurrence of frequency of cyhalothrin and cypermethrin was 9.55%, the combinations of pesticides detected with anti-androgenic effects has not been found in the present monitoring, the results indicate that the pesticide residues in bayberry will not constitute serious public health risk, however, they are significant for the management of pesticide use on bayberry and dietary health risk in China.
The research was supported by the National Natural Science Foundation of China (31301490), the Zhejiang Provincial Major Scientific and Technology Project for Agriculture, China (2015C02043), the Zhejiang Provincial Major Scientific and Research Project for Agriculture, China (ZJNY2017001).
Berrada H, Fernández M, Ruiz M, Moltó J, Mañes J, Font G. 2010. Surveillance of pesticide residues in fruits from Valencia during twenty months (2004/05). Food Control, 21, 36-44.
Bhanti M, Shukla G, Taneja A. 2004. Contamination levels of organochlorine pesticides and farmers’ knowledge, perception, practices in rural India: A case study. Bulletin of Environmental Contamination and Toxicology, 73, 787-793.
Boobis A R, Ossendorp B C, Banasiak U, Hamey P Y, Sebestyen I, Moretto A. 2008. Cumulative risk assessment of pesticide residues in food. Toxicology Letters, 180, 137-150.
Boon P E, Ruprich J, Petersen A, Moussavian S, Debegnach F, Klaveren J D V, Marvin H J P, Hart A, Boon P E. 2009. Harmonisation of food consumption data format for dietary exposure assessments of chemicals analysed in raw agricultural commodities. Food & Chemical Toxicology, 47, 2883-2889.
Chen D, Song Z, Lv H. 2012. Assay of picogram level isocarbophos residue on tangerines and oranges with luminol-albumin chemiluminescence system. Food Chemistry, 135, 2549-2553.
Cheng J, Ye X, Chen J, Liu D, Zhou S. 2008. Nutritional composition of underutilized bayberry (Myrica rubra Sieb. et Zucc.) kernels. Food Chemistry, 107, 1674-1680.
EFSA (European Food Safety Authority). 2013. The 2010 European Union report on pesticide residues in food. EFSA Journal, 11, 3130.
EFSA (European Food Safety Authority). 2016. Conclusion on the peer review of the pesticide risk assessment of the active substance rescalure. EFSA Journal, 13, 4031-4031.
FAO (Food and Agriculture Organization). 2002. Further guidance on derivation of the ARfD. Pesticide Residues in Food-2002. FAO Plant Production and Protection Paper, 172. FAO, Rome. pp. 4-8.
GB/T 8855-2008. 2008. Fresh Fruits and Vegetables Sampling. China Bureau of Quality and Technical Supervison. China Standard Press, Beijing. (in Chinese)
Guo Q, Yuan J, Zeng J, He X, Li D. 2012. Synthesis of dihydromyricetin-manganese (II) complex and interaction with DNA. Journal of Molecular Structure, 1027, 64-69.
Hamilton D, Ambrus Á, Dieterle R, Felsot A, Harris C, Petersen B, Tanaka K. 2004. Pesticide residues in food — acute dietary exposure. Pest Management Science, 60, 311-339.
He Y W, Shi T W, Wei R Y. 2011. Assessment of the antibacterial activity and the antidiarrheal function of flavonoids from bayberry fruit. Journal of Agricultural & Food Chemistry, 59, 5312-5317.
Iñigo-Nuñez S, Herreros M A, Encinas T, Gonzalez-Bulnes A. 2010. Estimated daily intake of pesticides and xenoestrogenic exposure by fruit consumption in the female population from a Mediterranean country (Spain). Food Control, 21, 471-477.
Jiao Y, Jia H, Li X, Chai M, Jia H, Chen Z, Wang G, Chai C, Weg E V D, Gao Z. 2012. Development of simple sequence repeat (SSR) markers from a genome survey of Chinese bayberry (Myrica rubra). BMC Genomics, 13, 201.
Laier P, Metzdorff S B, Borch J, Hagen M L, Hass U, Christiansen S, Axelstad M, Kledal T, Dalgaard M, Mckinnell C. 2006. Mechanisms of action underlying the antiandrogenic effects of the fungicide prochloraz. Toxicology & Applied Pharmacology, 213, 160-171.
LeBlanc G A, Bain L J, Wilson V S. 1997. Pesticides: Multiple mechanisms of demasculinization. Molecular and Cellular Endocrinology, 126, 1-5.
Li Z, Ma Z, Kuijp T J V D, Yuan Z, Huang L. 2014. A review of soil heavy metal pollution from mines in China: Pollution and health risk assessment. Science of the Total Environment, 468, 843-853.
Lozowicka B. 2015. Health risk for children and adults consuming apples with pesticide residue. Science of Total Environment, 502, 184-198.
Mnif W, Hassine A I H, Bouaziz A, Bartegi A, Thomas O, Roig B. 2011. Effect of endocrine disruptor pesticides: A review. International Journal of Environmental Research and Public Health, 8, 2265-2303.
Qian Y, Chen C, Zhang Q, Li Y, Chen Z, Li M. 2010. Concentrations of cadmium, lead, mercury and arsenic in Chinese market milled rice and associated population health risk. Food Control, 21, 1757-1763.
Rawn D, Roscoe V, Trelka R, Hanson C, Krakalovich T, Dabeka R. 2006. Methyl carbamate pesticide residues in conventional and organic infant foods available on the Canadian retail market, 2001-03. Food Additives and Contaminants, 23, 651-659.
Saillenfait A M, Ndiaye D, Sabaté J P. 2015. Pyrethroids: Exposure and health effects - An update. International Journal of Hygiene & Environmental Health, 218, 281.
Sherrard R, Murray-Gulde C, Rodgers J, Shah Y. 2003. Comparative toxicity of chlorothalonil: Ceriodaphnia dubia and Pimephales promelas. Ecotoxicology and Environmental Safety, 56, 327-333.
Singh A, Sharma R K, Agrawal M, Marshall F M. 2010. Health risk assessment of heavy metals via dietary intake of foodstuffs from the wastewater irrigated site of a dry tropical area of India. Food & Chemical Toxicology an International Journal Published for the British Industrial Biological Research Association, 48, 611-619.
Solecki R, Davies L, Dellarco V, Dewhurst I, Van Raaij M, Tritscher A. 2005. Guidance on setting of acute reference dose (ARfD) for pesticides. Food and Chemical Toxicology, 43, 1569-1593.
Waichman A V, Eve E, da Silva Nina N C. 2007. Do farmers understand the information displayed on pesticide product labels? A key question to reduce pesticides exposure and risk of poisoning in the Brazilian Amazon. Crop Protection, 26, 576-583.
Wang Z, Huang J, Chen J, Li F. 2013. Effectiveness of dishwashing liquids in removing chlorothalonil and chlorpyrifos residues from cherry tomatoes. Chemosphere, 92, 1022-1028.
Wu S, Liu B, Zhang Q, Liu J, Zhou W, Wang C, Zhu R. 2013. Dihydromyricetin reduced Bcl-2 expression via p53 in human hepatoma HepG2 cells. PLOS ONE, 8, e76886.
Xiao L Z, Xia Y, Liu S C, Guo W. 2008. Study on the antimicrobial effect of dihydromyricetin. Food Science and Technology, 4, 62.
Yang G, Lu J, Shou L, Zhang Z, Wang Q. 2013. The current situation of bayberry safety and counter measures in Zhejiang. Quanlity and Safety for Agricultural Products, 1, 20-22. (in Chinese)
Yang G, Yu Y, Wang Q, Hang Q, Zhao X, Wu S, Zhang Z, Cai Z. 2016. Risk assessment of pesticides on bayberry and its use. Quality and Safety of Agricultural Products, 1, 47-51. (in Chinese)
Yuan Y, Chen C, Zheng C, Wang X, Yang G, Wang Q, Zhang Z. 2014. Residue of chlorpyrifos and cypermethrin in vegetables and probabilistic esposure assessment for consumers in Zhejiang Province, China. Food Control, 36, 63-68.
Zumbado M, Goethals M, Alvarez-León E E, Luzardo O P, Cabrera F, Serra-Majem L, Domínguez-Boada L. 2005. Inadvertent exposure to organochlorine pesticides DDT and derivatives in people from the Canary Islands (Spain). Science of the Total Environment, 339, 49-62.