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| Cardiopulmonary, Biochemical and Haematological Effects of the Tiletamine/ Zolazepam-Xylazine-Tramadol Combination to Provide Anaesthesia in Miniature Pigs |
| LU De-zhang, FAN Hong-gang, JIANG Sheng, ZHANG Luan-song, MA Kun, YU Shi-ming, TAN Lijuan, WANG Hong-bin |
1.Department of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P.R.China
2.Department of Veterinary Surgery, College of Veterinary Medicine, Northwest Agricultrue and Forestry University, Yangling 712100, P.R.China |
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摘要 The objective of this study was to investigate the suitability of tiletamine/zolazepam-xylazine-tramadol combination for miniature pigs. Fourteen Chinese experimental miniature pigs subjected to this study received 3.5 mg tiletamine/zolazepam kg-1 bw, 1.32 mg xylazine kg-1 bw and 1.8 mg tramadol kg-1 bw intramuscularly, as a mixture of the drugs. Cardiopulmonary, biochemical and haematological parameters were recorded before drug administration and after anaesthesia. The combination of the compounds resulted in anaesthesia lasting about 87 min and a satisfactory immobilization for handling. Cardiopulmonary parameters were changed after administration, but there were within biologically acceptable limits. Biochemical and haematological values decreased after drug administration, however, they returned to the baseline at 24 h. At the doses described, tiletamine/zolazepam-xylazine-tramadol combination produced good immobilization in miniature pigs with minimal changes over time in cardiopulmonary, biochemical and haematological parameters.
Abstract The objective of this study was to investigate the suitability of tiletamine/zolazepam-xylazine-tramadol combination for miniature pigs. Fourteen Chinese experimental miniature pigs subjected to this study received 3.5 mg tiletamine/zolazepam kg-1 bw, 1.32 mg xylazine kg-1 bw and 1.8 mg tramadol kg-1 bw intramuscularly, as a mixture of the drugs. Cardiopulmonary, biochemical and haematological parameters were recorded before drug administration and after anaesthesia. The combination of the compounds resulted in anaesthesia lasting about 87 min and a satisfactory immobilization for handling. Cardiopulmonary parameters were changed after administration, but there were within biologically acceptable limits. Biochemical and haematological values decreased after drug administration, however, they returned to the baseline at 24 h. At the doses described, tiletamine/zolazepam-xylazine-tramadol combination produced good immobilization in miniature pigs with minimal changes over time in cardiopulmonary, biochemical and haematological parameters.
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Received: 19 August 2011
Accepted:
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| Fund: This study supported by the National Natural Science Foundation of China (30671552 and 30972227). |
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Corresponding Authors:
Correspondence WANG Hong-bin, Tel: +86-451-55191833, Fax: +86-451-55190470, E-mail: hbwang1940@yahoo.com.cn
E-mail: hbwang1940@yahoo.com.cn
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Cite this article:
LU De-zhang, FAN Hong-gang, JIANG Sheng, ZHANG Luan-song, MA Kun, YU Shi-ming, TAN Lijuan, WANG Hong-bin.
2012.
Cardiopulmonary, Biochemical and Haematological Effects of the Tiletamine/ Zolazepam-Xylazine-Tramadol Combination to Provide Anaesthesia in Miniature Pigs. Journal of Integrative Agriculture, 12(8): 1340-1346.
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