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Journal of Integrative Agriculture  2024, Vol. 23 Issue (11): 3938-3942    DOI: 10.1016/j.jia.2024.07.008
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Emergence of a novel multi-resistance-mediating integrative and conjugative element ICEPmu3 in Pasteurella multocida

Jiao He1, Zhishuang Yang1, Mingshu Wang1, 3, 4, Renyong Jia1, 3, 4, Shun Chen1, 2, 3, 4, Mafeng Liu1, 2, 3, 4, Xinxin Zhao1, 2, 3, 4, Qiao Yang1, 2, 3, 4, Ying Wu1, 2, 3, 4, Shaqiu Zhang1, 2, 3, 4, Juan Huang1, 2, 3, 4, Xumin Ou1, 2, 3, 4, Di Sun1, 2, 3, 4, Bin Tian1, 2, 3, 4, Yu He1, 2, 3, 4, Zhen Wu1, 2, 3, 4, Anchun Cheng1, 2, 3, 4#, Dekang Zhu1, 2, 3, 4#

1 Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China

2 Key Laboratory of Agricultural Bioinformatics, Ministry of Education, Chengdu 611100, China

3 International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu 610199, China

4 Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education, Chengdu 610199, China 

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摘要  

本研究从中国鸭中分离出一株高致病性且多重耐药的多杀性巴氏杆菌(Pasteurella multocidaPMHN141014基于HN141014的全基因组生物信息学分析及共轭转移试验,鉴定出一种新型的多重耐药整合接合元件ICEPmu3元件属于ICEHin1056亚家族,具有种内种间转移特性,包含除tfc1tfc20外几乎完整的Ⅳ型分泌系统,携带tetR(B)-tet(B)-tetCaph()-Iasul2-strA-strB等多种耐药基因。进一步分析发现,ICEPmu3还存在于亚洲和美洲其他3PM8禽类芽孢杆菌中。这些结果表明ICEPmu3出现和流行可能加剧养禽业中PM的防控难度



Received: 16 November 2023   Accepted: 22 April 2024
Fund: 
This work was supported by the earmarked fund for China Agriculture Research System (CARS-42-17), and the Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System (SCCXTD-2021-18).
About author:  Jiao He, Tel: +86-15680737990, E-mail: hejiaovet@163.com; #Correspondence Anchun Cheng, E-mail: chenganchun@vip.163.com; Dekang Zhu, E-mail: zdk24@sicau.edu.cn

Cite this article: 

Jiao He, Zhishuang Yang, Mingshu Wang, Renyong Jia, Shun Chen, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Bin Tian, Yu He, Zhen Wu, Anchun Cheng, Dekang Zhu. 2024. Emergence of a novel multi-resistance-mediating integrative and conjugative element ICEPmu3 in Pasteurella multocida. Journal of Integrative Agriculture, 23(11): 3938-3942.

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