Agüero J, Gómez-Aix C, Sempere R N, García-Villalba J, García-Núñez J, Hernando Y, Aranda M A. 2018. Stable and broad spectrum cross-protection against Pepino mosaic virus attained by mixed infection. Frontiers in Plant Science, 9, 1810.

Allard H A. 1916. Some properties of the virus of the mosaic disease of tobacco. Journal of Agricultural Research, 6, 649–674.

Anandalakshmi R, Pruss G J, Ge X, Marathe R, Mallory A C, Smith T H, Vance V B. 1998. A viral suppressor of gene silencing in plants. Proceedings of the National Academy of Sciences of the United States of America, 95, 13079–13084.

Bao Y, Carter S A, Nelson R S. 1996. The 126-and 183-kilodalton proteins of tobacco mosaic virus, and not their common nucleotide sequence, control mosaic symptom formation in tobacco. Journal of Virology, 70, 6378–6383.

Cheng X, Wang A. 2017. The potyvirus silencing suppressor protein VPg mediates degradation of SGS3 via ubiquitination and autophagy pathways. Journal of Virology, 91, e01478-e01494.

Chewachong G M, Miller S A, Blakeslee J J, Francis D M, Morris T J, Qu F. 2015. Generation of an attenuated, cross-protective Pepino mosaic virus variant through alignment-guided mutagenesis of the viral capsid protein. Phytopathology, 105, 126–134.

Cong Q, Wang Y, Liu J, Lan Y, Guo Z, Yang J, Li X, Tian Y. 2019. Evaluation of Potato virus X mild mutants for cross protection against severe infection in China. Virology Journal, 16, 36.

Dasgupta I, Malathi V, Mukherjee S. 2003. Genetic engineering for virus resistance. Current Chinese Science, 84, 341–354.

Ding X, Liu J, Cheng N, Folimonov A, Hou Y, Bao Y, Katagi C, Carter S A, Nelson R S. 2004. The Tobacco mosaic virus 126-kDa protein associated with virus replication and movement suppresses RNA silencing. Molecular Plant-Microbe Interactions, 17, 583–592.

Duan C G, Wang C H, Guo H S. 2012. Application of RNA silencing to plant disease resistance. Silence, 3, 1–8.

Ellis M D, Hoak J M, Ellis B W, Brown J A, Sit T L, Wilkinson C A, Reed T D, Welbaum G E. 2020. Quantitative real-time PCR analysis of individual flue-cured tobacco seeds and seedlings reveals seed transmission of tobacco mosaic virus. Phytopathology, 110, 194–205.

Fondong V N. 2019. The ever-expanding role of C4/AC4 in geminivirus infection: Punching above its weight? Molecular Plant, 12, 145–147.

Gal-On A, Shiboleth Y. 2006. Cross-protection. In: Loebenstein G, Carr J P, eds., Natural Resistance Mechanisms of Plants to Viruses. Springer, The Netherlands. A12, pp. 261–288.

Gao R, Tian Y, Wang J, Yin X, Li X, Valkonen J P. 2012. Construction of an infectious cDNA clone and gene expression vector of Tobacco vein banding mosaic virus (genus Potyvirus). Virus Research, 169, 276–281.

Goregaoker S P, Culver J N. 2003. Oligomerization and activity of the helicase domain of the tobacco mosaic virus 126-and 183-kilodalton replicase proteins. Journal of Virology, 77, 3549–3556.

Goregaoker S P, Lewandowski D J, Culver J N. 2001. Identification and functional analysis of an interaction between domains of the 126/183-kDa replicase-associated proteins of tobacco mosaic virus. Virology, 282, 320–328.

Guerrero J, Regedanz E, Lu L, Ruan J, Bisaro D M, Sunter G. 2020. Manipulation of the plant host by the Geminivirus AC2/C2 protein, a central player in the infection cycle. Frontiers in Plant Science, 11, 591.

Guo Q, Liu Q, A Smith N, Liang G, Wang M B. 2016. RNA silencing in plants: Mechanisms, technologies and applications in horticultural crops. Current Genomics, 17, 476–489.

Haikonen T, Rajamäki M L, Tian Y P, Valkonen J P T. 2013. Mutation of a short variable region in HCpro protein of Potato virus A affects interactions with a microtubule-associated protein and induces necrotic responses in tobacco. Molecular Plant–Microbe Interactions, 26, 721–733.

Hasiów-Jaroszewska B, Borodynko N, Jackowiak P, Figlerowicz M, Pospieszny H. 2011. Single mutation converts mild pathotype of the Pepino mosaic virus into necrotic one. Virus Research, 159, 57–61.

Hirashima K, Watanabe Y. 2001. Tobamovirus replicase coding region is involved in cell-to-cell movement. Journal of Virology, 75, 8831–8836.

Holmes F O. 1934. A masked strain of tobacco mosaic virus. Phytopathology, 24, 845–873.

Huang X D, Fang L, Gu Q S, Tian Y P, Geng C, Li X D. 2019. Cross protection against the watermelon strain of Papaya ringspot virus through modification of viral RNA silencing suppressor. Virus Research, 265, 166–171.

Jiang Y, Zheng W, Li J, Liu P, Zhong K, Jin P, Xu M, Yang J, Chen J. 2021. NbWRKY40 positively regulates the response of Nicotiana benthamiana to tomato mosaic virus via salicylic acid signaling. Frontiers in Plant Science, 11, 603518.

Kearney C, Thomson M, Roland K. 1999. Genome evolution of tobacco mosaic virus populations during long-term passaging in a diverse range of hosts. Archives of Virology, 144, 1513–1526.

Knapp E, Danyluk G M, Achor D, Lewandowski D J. 2005. A bipartite Tobacco mosaic virus defective RNA (dRNA) system to study the role of the N-terminal methyl transferase domain in cell-to-cell movement of dRNAs. Virology, 341, 47–58.

Kung Y, Lin P, Yeh S, Hong S, Chua N, Liu L, Lin C, Huang Y, Wu H, Chen C, Lin S. 2014. Genetic analyses of the FRNK motif function of Turnip mosaic virus uncover multiple and potentially interactive pathways of cross-protection. Molecular Plant–Microbe Interactions, 27, 944–955.

Lewandowski D J, Dawson W O. 1993. A single amino acid change in tobacco mosaic virus replicase prevents symptom production. Molecular Plant–Microbe Interactions, 6, 157.

Lewandowski D J, Dawson W O. 2000. Functions of the 126-and 183-kDa proteins of tobacco mosaic virus. Virology, 271, 90–98.

Lin S S, Wu H W, Jan F J, Hou R F, Yeh S D. 2007. Modifications of the helper component-protease of Zucchini yellow mosaic virus for generation of attenuated mutants for cross protection against severe infection. Phytopathology, 97, 287–296.

Liu H, Naismith J H. 2008. An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol. BMC Biotechnology, 8, 91.

Liu J, Li X D, Xu S. 2020. Single amino acid substitutions in the coat protein and RNA-dependent RNA polymerase alleviated the virulence of Cucumber green mottle mosaic virus and conferred cross protection against severe infection. Virus Research, 56, 228–235.

Liu L, Peng B, Zhang Z, Wu Y, Miras M, Aranda M A, Gu Q. 2017. Exploring different mutations at a single amino acid position of Cucumber green mottle mosaic virus replicase to attain stable symptom attenuation. Phytopathology, 107, 1080–1086.

Mascia T, Santovito E, Gallitelli D, Cillo F. 2010. Evaluation of reference genes for quantitative reverse-transcription polymerase chain reaction normalization in infected tomato plants. Molecular Plant Pathology, 11, 805–816.

Oshima N, Komochi S, Goto T. 1965. Study on control of plant virus diseases by vaccination of attenuated virus. (i) Control of tomato mosaic disease. Hokkaido National Agricultural Experiment Station Research Bull, 85, 23–33.

Pechinger K, Chooi K M, MacDiarmid R M, Harper S J, Ziebell H. 2019. A new era for mild strain cross-protection. Viruses, 11, 670.

Peng J, Song K, Zhu H, Kong W, Liu F, Shen T, He Y. 2017. Fast detection of tobacco mosaic virus infected tobacco using laser-induced breakdown spectroscopy. Sciences Report, 7, 1–9.

Raja J A, Huang C H, Chen C C, Hu W C, Cheng H W, Goh R P, Chao C H, Tan Y R, Yeh S D. 2022. Modification of the N-terminal FWKG-αH1 element of potyviral HC-Pro affects its multiple functions and generates effective attenuated mutants for cross-protection. Molecular Plant Pathology, 23, 947–965.

Rajamäki M L, Streng J, Valkonen J P. 2014. Silencing suppressor protein VPg of a potyvirus interacts with the plant silencing-related protein SGS3. Molecular Plant–Microbe Interactions, 27, 1199–1210.

Rast A T B. 1972. M II-16, an artificial symptomless mutant of tobacco mosaic virus for seedling inoculation of tomato crops. Netherlands Journal of Plant Pathology, 78, 110–112.

Rast A T B. 1975. Variability of Tobacco Mosaic Virus in Relation to Control of Tomato Mosaic in Glasshouse Tomato Crops by Resistance Breeding and Cross Protection. Wageningen University and Research, The Netherlands.

Sawalha H. 2014. Quantitative effects of single and multiple infections with four viruses on tomato production. Annual Research & Review in Biology, 4, 2804–2814.

Scholthof K B G, Adkins S, Czosnek H, Palukaitis P, Jacquot E, Hohn T, Hohn B, Saunders K, Candresse T, Ahlquist P. 2011. Top 10 plant viruses in molecular plant pathology. Molecular Plant Pathology, 12, 938–954.

Shintaku M H, Carter S A, Bao Y, Nelson R S. 1996. Mapping nucleotides in the 126-kDa protein gene that control the differential symptoms induced by two strains of tobacco mosaic virus. Virology, 221, 218–225.

Stoykova D, Dratchev D. 2001. Study on the effect of Tobacco mosaic virus (TMV) and Potato virus Y (PVY) on tobacco quality. Biotechnology & Biotechnological Equipment, 15, 62–64.

Sun L, Suzuki N. 2008. Intragenic rearrangements of a mycoreovirus induced by the multifunctional protein p29 encoded by the prototypic hypovirus CHV1-EP713. RNA, 14, 2557–2571.

Tosh P K, Boyce T G, Poland G A. 2008. Flu myths: Dispelling the myths associated with live attenuated influenza vaccine. Mayo Clinic Proceedings, 83, 77–84.

Tuo D, Zhou P, Zhao G, Yan P, Tan D, Li X, Shen W. 2020. A double mutation in the conserved motifs of the helper component protease of papaya leaf distortion mosaic virus for the generation of a cross-protective attenuated strain. Phytopathology, 110, 187–193.

Wang J, Chen T, Han M, Qian L, Li J, Wu M, Han T, Cao J, Nagalakshmi U, Rathjen J P. 2020. Plant NLR immune receptor Tm-22 activation requires NB-ARC domain-mediated self-association of CC domain. PLoS Pathogens, 16, e1008475.

Wang L Y, Lin S S, Hung T H, Li T K, Lin N C, Shen T L. 2012. Multiple domains of the Tobacco mosaic virus p126 protein can independently suppress local and systemic RNA silencing. Molecular Plant-Microbe Interactions, 25, 648–657.

Wang M B, Masuta C, Smith N A, Shimura H. 2012. RNA silencing and plant viral diseases. Molecular Plant–Microbe Interactions, 25, 1275–1285.

Van Wezel R, Dong X, Blake P, Stanley J, Hong Y. 2002. Differential roles of geminivirus Rep and AC4 (C4) in the induction of necrosis in Nicotiana benthamiana. Molecular Plant Pathology, 3, 461–471.

Wyrsch I, Domínguez-Ferreras A, Geldner N, Boller T. 2015. Tissue-specific FLAGELLIN-SENSING 2 (FLS2) expression in roots restores immune responses in Arabidopsis fls2 mutants. New Phytologist, 206, 774–784.

Xu X J, Li H G, Cheng D J, Liu L Z, Geng C, Tian Y P, Li X D. 2020. A spontaneous complementary mutation restores the RNA silencing suppression activity of HC-pro and the virulence of sugarcane mosaic virus. Frontiers in Plant Science, 11, 1279.

Xu X J, Zhu Q, Jiang S Y, Yan Z Y, Geng C, Tian Y P, Li X D. 2021. Development and evaluation of stable sugarcane mosaic virus mild mutants for cross-protection against infection by severe strain. Frontiers in Plant Science, 12, 788963.

Yamaji Y, Kobayashi T, Hamada K, Sakurai K, Yoshii A, Suzuki M, Namba S, Hibi T. 2006. In vivo interaction between Tobacco mosaic virus RNA-dependent RNA polymerase and host translation elongation factor 1A. Virology, 347, 100–108.

Yoon J Y, Ahn H I, Kim M, Tsuda S, Ryu K H. 2006. Pepper mild mottle virus pathogenicity determinants and cross protection effect of attenuated mutants in pepper. Virus Research, 118, 23–30.

Zhang H, Zhao J, Liu S, Zhang D P, Liu Y. 2013. Tm-22 confers different resistance responses against tobacco mosaic virus dependent on its expression level. Molecular Plant, 6, 971–974.

Zhao S, Gong P, Ren Y, Liu H, Li H, Li F, Zhou X. 2022. The novel C5 protein from tomato yellow leaf curl virus is a virulence factor and suppressor of gene silencing. Stress Biology, 2, 19.

Zhou C, Zhou Y. 2012. Strategies for viral cross protection in plants. Methods in Molecular Biology, 894, 69–81.

Ziebell H, Payne T, Berry J O, Walsh J A, Carr J P. 2007. A cucumber mosaic virus mutant lacking the 2b counter-defence protein gene provides protection against wild-type strains. Journal of General Virology, 88, 2862–2871.