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Journal of Integrative Agriculture  2022, Vol. 21 Issue (7): 1839-1866    DOI: 10.1016/S2095-3119(21)63871-6
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Roles of mushroom polysaccharides in chronic disease management

ZHANG Shan1, LEI Lin1, ZHOU Yun1, YE Fa-yin1, ZHAO Guo-hua1,2

1 College of Food Science, Southwest University, Chongqing 400715, P.R. China

2 Chongqing Engineering Research Centre of Regional Foods, Chongqing 400716, P.R. China

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摘要  

慢性疾病是造成死亡和残疾的主要原因,引起了人们的广泛关注。蘑菇多糖具有多种多样的生物活性,在探索抗慢性疾病的新型无副作用药物方面备受关注。本文综述了在癌症、糖尿病和心血管疾病治疗方面的蘑菇多糖的结构特征、生物学性能及其分子机制。蘑菇多糖抗慢性疾病的潜力在很大程度上取决于其结构特征,包括单糖组成、分子量、糖苷键的类型和构型、支化度、取代基类型和链构象。关于蘑菇多糖的作用机制,有三种疾病共有的途径,也有特定于某种疾病的途径。某些信号通路的调节和肠道菌群的调节是三种慢性疾病共有的途径。此外,转录因子、受体、酶、激素等功能蛋白在蘑菇多糖抗慢性病分子机制中的作用在本文中做了阐述。本文总结了蘑菇多糖治疗慢性疾病的研究现状,并展望了蘑菇多糖治疗慢性疾病的研究前景,有望促进这方面的研究。




Abstract  Chronic diseases have drawn much attention as the primary cause of death and disability.  In exploring novel side-effect-free agents against chronic diseases, significant efforts have been devoted to mushroom polysaccharides due to their diverse biological activities.  This work reviewed the structural features, biological performances and molecular mechanisms of mushroom polysaccharides in managing cancers, diabetes mellitus and cardiovascular diseases.  The potentials of mushroom polysaccharides against chronic diseases highly depend on their structural features, including monosaccharide composition, molecular weight, the type and configuration of glycosidic bonds, degree of branching, the type of substituent pattern and chain conformation.  Regarding their working mechanisms, shared and disease-specific pathways were found.  The three chronic diseases shared the regulation of specific signalling pathways and the adjustment of gut microbiota.  In addition, the roles of transcription factors, receptors, enzymes, hormones and other functional proteins involved in the molecular mechanisms of mushroom polysaccharides against chronic diseases are first elaborated herein.  The present review describes the state of the art of mushroom polysaccharides in treating chronic diseases and addresses the perspectives, and will further promote research on this topic.
Keywords:  mushroom polysaccharide       chronic diseases       structural feature       biological performance       molecular mechanism  
Received: 05 May 2021   Accepted: 18 November 2021
About author:  ZHANG Shan, E-mail: 1147606079@qq.com; Correspondence ZHAO Guo-hua, Tel: +86-23-68251902, Fax: +86-23-68251947, E-mail: zhaogh@swu.edu.cn

Cite this article: 

ZHANG Shan, LEI Lin, ZHOU Yun, YE Fa-yin, ZHAO Guo-hua. 2022. Roles of mushroom polysaccharides in chronic disease management. Journal of Integrative Agriculture, 21(7): 1839-1866.

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