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Special Issue:
动物营养合辑Animal Nutrition
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| Recent advances in immunocastration in sheep and goat and its animal welfare benefits: A review |
| ZENG Fan-mei1*, DING Yi1, 2*, Teketay WASSIE2, JING Hai-jing1, 2, Sohail AHMED2, LIU Gui-qiong1, 2, JIANG Xun-ping1, 2 |
1 Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, P.R.China
2 Laboratory of Sheep and Goat Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, P.R.China |
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摘要
雄性动物去势是畜牧行业中一种常见的做法，目的是减少动物的攻击性行为、防止异味和控制繁殖。多年来，机械去势和手术去势被广泛应用于动物绝育。然而，这些去势方法会给动物带来疼痛和恐慌，影响动物福利。最近，针对下丘脑-垂体-性腺（HPG）轴的免疫去势被认为是传统去势的有效替代方法，避免了传统去势技术的许多缺点。一般来说，它是有效的、安全的，对动物友好，适用于所有阶段的动物。然而，目前还没有关于绵羊和山羊免疫去势的最新资料。因此，本篇综述概括了从传统手术去势到免疫去势的发展历程，比较了传统去势技术与免疫去势技术的优缺点，并总结了免疫靶标的筛选过程。功能性去势以HPG轴上的激素、基因和受体为靶标，开发针对它们的免疫去势疫苗。位于HPG轴上游的靶点，如吻素（KISS1）和促性腺激素释放激素（GnRH），已被证明能有效地降低性激素水平和抑制生殖功能。因此，开发绵羊和山羊的商业去势疫苗应通过使用HPG轴上的上游来开发。另外，本文还综述了近年来绵羊和山羊免疫去势的特点、应用及福利等方面的研究进展。总之，这篇综述为绵羊和山羊免疫去势作为手术去势的替代方法提供了有用信息。
Abstract Castration of male animals is a common practice in the meat industry aimed at reducing aggressive behavior, preventing unpleasant flavor, and controlling undesirable breeding. For many years, mechanical castration and surgical castration have been practiced to sterilize the animals. However, these castration methods are not humane because of the associated risk of death, pain, and stress. Recently, immunocastration targeting the hypothalamic-pituitary-gonadal axis (HPG) axis has been reported as an animal-friendly approach that circumvents many of the concerns with conventional castration, and suggested by researches as an alternative to surgical castration. However, there is no compilation of updated information on the use of immunocastration in sheep and goats. Therefore, this review aims to summarize the developmental process from traditional surgical castration to immunocastration and to screen the process of immune targets. It also compares the respective advantages and disadvantages of traditional castration technologies and immunocastration, in particular including analyses in the characteristics, features application and welfare benefits of immunocastration in sheep and goats were also analyzed.
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Received: 09 August 2020
Accepted: 03 January 2021
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| Fund: This work was funded by the National Natural Science Foundation of China (31972997 and 31772598), and the China Agriculture Research System of MOF and MARA (CARS-38). |
| About author: ZENG Fan-mei, E-mail: zzzengfm@163.com; DING Yi, E-mail: dingyi_dk@qq.com; Correspondence JIANG Xun-ping, Tel/Fax: +86-27-8758512, E-mail: xpjiang@mail.hzau.edu.cn
* These authors contributed equally to this study. |
Cite this article:
ZENG Fan-mei, DING Yi, Teketay WASSIE, JING Hai-jing, Sohail AHMED, LIU Gui-qiong, JIANG Xun-ping.
2022.
Recent advances in immunocastration in sheep and goat and its animal welfare benefits: A review. Journal of Integrative Agriculture, 21(2): 299-309.
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