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Journal of Integrative Agriculture  2020, Vol. 19 Issue (6): 1429-1438    DOI: 10.1016/S2095-3119(19)62804-2
Special Focus: Physiology and interaction of insects with environmental factors Advanced Online Publication | Current Issue | Archive | Adv Search |
Structure and function of neuropeptide F in insects
CUI Hong-ying, ZHAO Zhang-wu
Department of Entomology/MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, P.R.China
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Insect neuropeptides are a group of brain neuro-regulatory factors, which plays very important roles in growth and development, molting and metamorphosis, as well as mating and reproduction.  The neuropeptide F (NPF), a multi-functional neuropeptide, is one of neuropeptides identified in numerous insect species, which plays important roles in feeding, metabolism, courtship, reproduction, aggression, ethanol sensitivity, locomotor circadian rhythms, learning and stress responses.  These roles of NPF are implemented through NPF receptors (NPFR).  The NPFR1, a G protein-coupled receptor with 7 transmembrane domains, is one of these receptors and is found to be important for NPF regulation.  The NPF usually is consisted of around 36–40 amino acid residues, but the short neuropeptide F (sNPF) consisted of 7–16 amino acid residues have also been found in some insects.  In this review, the structure and function of both NPF and sNPF in insects are discussed. 
Keywords:  neuropeptide        NPF        sNPF        NPFR1        insects  
Received: 09 May 2019   Accepted:
Fund: This work is supported by grant from the National Natural Science Foundation of China (31730076).
Corresponding Authors:  Correspondence ZHAO Zhang-wu, E-mail:    
About author:  CUI Hong-ying, E-mail:;

Cite this article: 

CUI Hong-ying, ZHAO Zhang-wu. 2020. Structure and function of neuropeptide F in insects. Journal of Integrative Agriculture, 19(6): 1429-1438.

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