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Journal of Integrative Agriculture  2019, Vol. 18 Issue (4): 821-829    DOI: 10.1016/S2095-3119(18)62047-7
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Chinese wheat mosaic virus: A long-term threat to wheat in China
GUO Liu-ming1, 2, HE Jing1, 2, LI Jing2, CHEN Jian-ping2, ZHANG Heng-mu1, 2
1 College of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, P.R.China
2 State Key Laboratory Breeding Base for Zhejiang Sustain Pest and Disease Control/MOA and Zhejiang Key Laboratory of Plant Protection and Biotechnology, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, P.R.China
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In China, a soil-borne virus causing a disease of winter wheat and associated with Polymyxa graminis, has been reported for many years and is now recognized as a new species, Chinese wheat mosaic virus (CWMV).  Since the determination of its genomic sequence, more progress has been made in understanding its genomic structure and functions.  Molecular and serological methods have been developed to help survey the distribution of the virus and to provide the basic information needed for disease forecasting and control.  At present, the best countermeasure is cultivation of resistant wheat varieties.  In addition, development and application of some auxiliary countermeasures, such as rotation of non-host crops, delayed seed-sowing, reasonable application of nitrogen fertilizer, and treatment of imported seeds with fungicides before sowing, may be helpful for controlling the disease.  The viral distribution and damage, virion properties, genome organization and spontaneous mutation, temperature sensitivity, and disease management options are here reviewed and/or discussed to help in developing more cost-effective countermeasures to control the disease in the future.
Keywords:  Chinese wheat mosaic virus (CWMV)       Polymyxa graminis        disease control        genome structure        spontaneous mutation        temperature sensitivity  
Received: 13 December 2017   Accepted:
Fund: This work was funded by the National Natural Science Foundation of China (31501604 and 31601603), the Project of New Varieties of Genetically Modified Wheat of China (2016ZX08002001), the Special Fund for Agro-scientific Research in the Public Interest of China (201303021), the earmarked fund for China Agriculture Research System (CARS-3-1), and the State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, China (2010DS700124-KF1512 and 2010DS700124-KF1607).
Corresponding Authors:  Correspondence ZHANG Heng-mu, E-mail:   
About author:  GUO Liu-ming, E-mail:;
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GUO Liu-ming
HE Jing
LI Jing
CHEN Jian-ping
ZHANG Heng-mu

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GUO Liu-ming, HE Jing, LI Jing, CHEN Jian-ping, ZHANG Heng-mu. 2019. Chinese wheat mosaic virus: A long-term threat to wheat in China. Journal of Integrative Agriculture, 18(4): 821-829.

Adams M J. 1991. Transmission of plant viruses by fungi. Annals of Applied Biology, 118, 479–492.
Adams M J, Antoniw J F, Kreuze J. 2009. Virgaviridae: A new family of rod-shaped plant viruses. Archives of Virology, 154, 1967–1972.
Adams M J, Antoniw J F, Mullins J G. 2001. Plant virus transmission by plasmodiophorid fungi is associated with distinctive transmembrane regions of virus-encoded proteins. Archives of Virology, 146, 1139–1153.
Adams M J, Jacquier C. 1994. Infection of cereals and grasses by isolates of Polymyxa graminis (Plasmodiophorales). Annals of Applied Biology, 125, 53–60.
An H, Melcher U, Doss P, Payton M, Guenzi A C, Verchot-Lubicz J. 2003. Evidence that the 37 kDa protein of Soil-borne wheat mosaic virus is a virus movement protein. Journal of General Virology, 84, 3153–3163.
Andika I B, Sun L, Xiang R, Li J, Chen J. 2013a. Root-specific role for Nicotiana benthamiana RDR6 in the inhibition of Chinese wheat mosaic virus accumulation at higher temperatures. Molecular Plant-Microbe Interactions, 26, 1165–1175.
Andika I B, Zheng S, Tan Z, Sun L, Kondo H, Zhou X, Chen J. 2013b. Endoplasmic reticulum export and vesicle formation of the movement protein of Chinese wheat mosaic virus are regulated by two transmembrane domains and depend on the secretory pathway. Virology, 435, 493–503.
Baulcombe D. 2004. RNA silencing in plants. Nature, 431, 356–363.
Bouzoubaa S E. 1998. Furovirus isolation and RNA extraction. Methods in Molecular Biology, 81, 107–114.
Campbell R N. 1996. Fungal transmission of plant viruses. Annual Review of Phytopathology, 34, 87–108.
Chen J P. 1993. Occurrence of fungally transmitted Wheat mosaic viruses in China. Annals of Applied Biology, 123, 55–61.
Chen J P, Chen J, Zhang H M, Zheng H Y, Lin L, Chen Y, Zheng T, Shi Y H. 2005. In: Plant Viruses Transmitted by Fungi. Science Press, Beijing, China. (in Chinese)
Chen J P, MacFarlane S A, Wilson T M A. 1994. Detection and sequence analysis of a spontaneous deletion mutant of SBWMV RNA2 associated with increased symptom severity. Virology, 202, 921–929.
Chen J P, MacFarlane S A, Wilson T M A. 1995. An analysis of spontaneous deletion sites in Soil-borne wheat mosaic virus RNA2. Virology, 209, 213–217.
Cheng Z B, Deng J H, Yue Y C, Liu H J, Cheng C G, You S L, Xing W F, Gu W Z, Zhou Y J, Fan Y J. 2005. Identification of two wheat virus diseases caused by Chinese wheat mosaic virus and Rice stripe virus in Jiangsu province. Acta Phytopathologica Sinica, 35, 125–128. (in Chinese)
Colussi T M, Costantino D A, Hammond J A, Ruehle G M, Nix J C, Kieft J S. 2014. The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA. Nature, 511, 366–369.
Diao A, Chen J, Ye R, Zheng T, Yu S, Antoniw J F, Adams M J. 1999. Complete sequence and genome properties of Chinese wheat mosaic virus, a new furovirus from China. Journal of General Virology, 80, 1141–1145.
Dreher T W. 2009. Role of tRNA-like structures in controlling plant virus replication. Virus Research, 139, 217–229.
Fukuta S, Tamura M, Maejima H, Takahashi R, Kuwayama S, Tsuji T, Yoshida T, Itoh K, Hashizume H, Nakajima Y, Uehara Y, Shirako Y. 2013. Differential detection of Wheat yellow mosaic virus, Japanese soil-borne wheat mosaic virus and Chinese wheat mosaic virus by reverse transcription loop-mediated isothermal amplification reaction. Journal of Virological Methods, 189, 348–354.
Ghoshal B, Sanfaçon H. 2014. Temperature-dependent symptom recovery in Nicotiana benthamiana plants infected with Tomato ringspot virus is associated with reduced translation of viral RNA2 and requires ARGONAUTE1. Virology, 456–457, 188–197.
Ghoshal B, Sanfaçon H. 2015. Symptom recovery in virus-infected plants: Revisiting the role of RNA silencing mechanisms. Virology, 479–480, 167–179.
Goodwin J B, Dreher T W. 1998. Transfer RNA mimicry in a new group of positive-strand RNA plant viruses, the furoviruses: Differential aminoacylation between the RNA components of one genome. Virology, 246, 170–178.
Hammond J A, Rambo R P, Kieft J S. 2010. Multi-domain packing in the aminoacylatable 3´ end of a plant viral RNA. Journal of Molecular Biology, 399, 450–463.
King A M, Adams M J, Carstens E B, Lefkowitz E. 2011. Virus taxonomy: Ninth report of the international committee on taxonomy of viruses. Archives of Virology, 140, 391–392.
Kühne T. 2009. Soil-borne viruses affecting cereals: Known for long but still a threat. Virus Research, 141, 1174–1183.
Liu H, Li N, Zhou X P, Ren C M, Cheng Z B, Wu J X. 2015. Development of monoclonal antibodies against Chinese wheat mosaic virus (CWMV) and their application. Journal of Agricultural Biotechnology, 23, 711–719. (in Chinese)
Miao Q, Ji Y H, Ren C M, Wei L H, Zhou Y J, Cheng Z B. 2013. A simplified method for quick detection of Wheat mosaic virus and Chinese wheat mosaic virus. Journal of Triticeae Crops, 33, 595–599. (in Chinese)
Mizumoto H, Hikichi Y, Okuno T. 2002. The 3´-untranslated region of RNA1 as a primary determinant of temperature sensitivity of Red clover necrotic mosaic virus Canadian strain. Virology, 293, 320–327.
Ohsato S, Miyanishi M, Shirako Y. 2003. The optimal temperature for RNA replication in cells infected by Soil-borne wheat mosaic virus is 17 degrees C. Journal of General Virology, 84, 995–1000.
Ren C M, Cheng Z B, Zhu H, Tai L J, Lu F X, Bao C H, Fan Y J, Zhou Y J. 2014. Development of multiclonal antibodies against 3 Triticeae soil-borne mosaic viruses and their application. Jiangsu Agricultural Sciences, 42, 143–146. (in Chinese)
Shirako Y, Brakke M K. 1984a. Two puri?ed RNAs of Soil-borne wheat mosaic virus are needed for infection. Journal of General Virology, 65, 119–127.
Shirako Y, Brakke M K. 1984b. Spontaneous deletion mutation of Soil-borne wheat mosaic virus RNA II. Journal of General Virology, 65, 855–858.
Sun B J, Yang J, Sun L Y, Cheng Z B, Xie L, Jiang H M, Zheng J Q, Zhao Q, Xie L H, Chen J P. 2011. Distribution and dynamics of Polymyxa graminis transmitted wheat viruses in China. Journal of Triticeae Crops, 31, 969–973. (in Chinese)
Sun L, Andika I B, Kondo H, Chen J. 2013b. Identification of the amino acid residues and domains in the cysteine-rich protein of Chinese wheat mosaic virus that are important for RNA silencing suppression and subcellular localization. Molecular Plant Pathology, 14, 265–278.
Sun L, Andika I B, Shen J, Yang D, Ratti C, Chen J. 2013a. The CUG-initiated larger form coat protein of Chinese wheat mosaic virus binds to the cysteine-rich RNA silencing suppressor. Virus Research, 177, 66–74.
Szittya G, Silhavy D, Molnar A, Havelda Z, Lovas A, Lakatos L, Banfalvi Z, Burgyan J. 2003. Low temperature inhibits RNA silencing-mediated defence by the control of siRNA generation. The European Molecular Biology Organization (EMBO) Journal, 22, 633–640.
Velázquez K, Renovell A, Comellas M, Serra P, García M L, Pina JA, Navarro L, Moreno P, and Guerri J. 2010. Effect of temperature on RNA silencing of a negative-stranded RNA plant virus: Citrus psorosis virus. Plant Pathology, 59, 982–990.
Te J, Melcher U, Howard A, Verchot-Lubicz J. 2005. Soilborne wheat mosaic virus (SBWMV) 19K protein belongs to a class of cysteine rich proteins that suppress RNA silencing. Virology Journal, 2, 18.
Xu L, Chen J P, Ye R, Zhao X Y, Yu S Q. 2002. Cloning and expression of the Chinese wheat mosaic virus RNA2 coat protein read-through and 19 ku cysteine-rich domains and localization of these proteins. Chinese Science Bulletin, 47, 1019–1023. (in Chinese)
Yang J, Zhang F, Cai N J, Wu N, Chen X, Li J, Meng X F, Zhu T Q, Chen J P, Zhang H M. 2017. A furoviral replicase recruits host HSP70 to membranes for viral RNA replication. Scientific Reports, 7, 45590.
Yang J, Zhang F, Xie L, Song X J, Li J, Chen J P, Zhang H M. 2016. Functional identification of two minor capsid proteins from Chinese wheat mosaic virus using its infectious full-length cDNA clones. Journal of General Virology, 97, 2441–2450.
Yang J, Zheng S L, Zhang H M, Liu X Y, Li J, Li J M, Chen J P. 2014. Analysis of small RNAs derived from Chinese wheat mosaic virus. Archives of Virology, 159, 3077–3082.
Yang J P, Chen J, Chen J P, Jiang H M, Zhao Q, Adams M J. 2001. Sequence of a second isolate of Chinese wheat mosaic furovirus. Journal of Phytopathology, 149, 135–140.
Yang J P, Chen J P, Cheng Y, Chen J, Jiang H M, Liu Q, Yang K S, Xu H, Adams M J. 2002. Responses of some American, European and Japanese wheat cultivars to soil-borne wheat viruses in China. Journal of Integrative Agriculture, 1, 1141–1150.
Ye R, Xu L, Gao Z Z, Yang J P, Chen J, Chen J P, Adams J and Yu S Q. 2000a. Use of monoclonal antibodies for the serological differentiation of wheat and oat Furoviruses. Journal of Phytopathology, 148, 257–262.
Ye R, Zheng T, Chen J, Diao A, Adams M J, Yu S, Antoniw J F. 1999. Characterization and partial sequence of a new furovirus of wheat in China. Plant Pathology, 48, 379–387.
Ye R, Zheng T, Xu L, Lei J L, Chen J P, Yu S Q. 2000b. Co-infection of wheat yellow mosaic virus and rodshaped virus related to soil-borne wheat mosaic virus on winter wheat in Yantai district. Chinese Journal of Virology, 16, 80–83. (in Chinese)
Ye Y J, Gong Z X. 1998. Cloning, expression and identification of matrix protein gene of Wheat rosette stunt virus (WRSV). Acta Biochimica et Biophysica Sinica, 30, 520–524.
Zhang F, Cai N J, Yang J, Li J, Chen J P, Zhang H M. 2017. Expression assays of replicase genes from Chinese wheat mosaic virus in infected plants. Acta Phytopathologica Sinica, 47, 640–646. (in Chinese)
Zhang P, Liu Y, Liu W, Cao M, Massart S, Wang X. 2017. Identification, characterization and full-length sequence analysis of a novel polerovirus associated with wheat leaf yellowing disease. Frontiers in Microbiology, 8, 1689.
Zhang Q Y, Chen J P. 2005. Biological properties of Chinese wheat mosaic virus (CWMV). Acta Agriculturae Zhejiangensis, 17, 155–157. (in Chinese)
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