Please wait a minute...
Journal of Integrative Agriculture  2019, Vol. 18 Issue (4): 840-853    DOI: 10.1016/S2095-3119(18)61929-X
Review Advanced Online Publication | Current Issue | Archive | Adv Search |
Progress of the discovery, application, and control technologies of chemical pesticides in China
PAN Xing-lu, DONG Feng-shou, WU Xiao-hu, XU Jun, LIU Xin-gang, ZHENG Yong-quan
State Key Laboratory for Biology of Plant Disease and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China
Download:  PDF (817KB) ( )  
Export:  BibTeX | EndNote (RIS)      
Pesticides, which have the dual characteristics of being both helpful and harmful, are important materials for ensuring food security and human health.  Therefore, the rational development, scientific application, and effective control of pesticides are very important.  In this paper, from the perspectives of pesticide discovery, formulation processing, application mode, residue monitoring, and pollution elimination and prediction, trends in the research progress and development of pesticides in China were systematically summarized to provide an important reference for the development of pesticides with high efficiency and low risk and for the reduction of pesticide application.
Keywords:  pesticide discovery        formulation processing        application        residue monitoring        pollution elimination and prediction  
Received: 07 November 2017   Accepted:
Fund: This work was supported by the National Key Research and Development Program of China (2016YFD0200204).
Corresponding Authors:  Correspondence ZHENG Yong-quan, Tel: +86-10-62815908, E-mail:    
About author: 

Cite this article: 

PAN Xing-lu, DONG Feng-shou, WU Xiao-hu, XU Jun, LIU Xin-gang, ZHENG Yong-quan . 2019. Progress of the discovery, application, and control technologies of chemical pesticides in China. Journal of Integrative Agriculture, 18(4): 840-853.

Angioni A, Dedola F, Garau V L, Schirra M, Caboni P. 2011. Fate of iprovalicarb, indoxacarb, and boscalid residues in grapes and wine by GC-ITMS analysis. Journal of Agricultural & Food Chemistry, 59, 6806–6812.
Balinova A M, Mladenova R I, Shtereva D D. 2006. Effects of processing on pesticide residues in peaches intended for baby food. Food Additives & Contaminants, 23, 895.
Biswas A K, Kondaiah N, Anjaneyulu A S R, Rao G S, Singh R P. 2010. A simple assay for analyzing residues of carbaryl insecticide in buffalo meat by liquid chromatography-photodiode array detection. Analytical Methods, 2, 393–396.
Burnley J. 2011. Biomimetic electrocyclization reactions toward polyketide-derived natural products. Biomimetic Organic Synthesis, 42, 895–901.
Buszewicz G, Rejczak T, Tuzimski T, Teresiński G, Pieni??ek D. 2016. Comparison of SPE/d-SPE and QuEChERS-based extraction procedures in terms of fungicide residue analysis in wine samples by HPLC-DAD and LC-QqQ-MS. Journal of AOAC International, 99, 1436–1443.
Cao Y, Huang L, Chen J, Liang J, Long S, Lu Y. 2005. Development of a controlled release formulation based on a starch matrix system. International Journal of Pharmaceutics, 298, 108–116.
Cengiz M F, Certel M, Karaka? B, Göçmen H. 2007. Residue contents of captan and procymidone applied on tomatoes grown in greenhouses and their reduction by duration of a pre-harvest interval and post-harvest culinary applications. Food Chemistry, 100, 1611–1619.
Chen H, Yada R. 2011. Nanotechnologies in agriculture: New tools for sustainable development. Trends in Food Science & Technology, 22, 585–594.
Chen W, Liu Y, Jiao B. 2016. Dissipation behavior of five organophosphorus pesticides in kumquat sample during honeyed kumquat candied fruit processing. Food Control, 66, 87–92.
Cheng Y, Zhou J Y, Shan Z J, Kong D Y. 2007. SCI-GROW model for groundwater risk assessment of pesticides. Journal of Ecology & Rural Environment, 23, 78–82.
Distante C, Leo M, Siciliano P, Persaud K C. 2002. On the study of feature extraction methods for an electronic nose. Sensors & Actuators (B: Chemical), 87, 274–288.
Dong F, Chen X, Liu X, Xu J, Li Y, Shan W, Zheng Y. 2012. Simultaneous determination of five pyrazole fungicides in cereals, vegetables and fruits using liquid chromatography/tandem mass spectrometry. Journal of Chromatography (A), 1262, 98.
Du X, Ren Y, Beckett S J. 2016. An Innovative rapid method for analysis of 10 organophosphorus pesticide residues in wheat by HS-SPME-GC-FPD/MSD. Journal of AOAC International, 99, 520–526.
El-Ali J, Sorger P K, Jensen K F. 2006. Cells on chips. Nature, 442, 403–411.
Feng X P, Chen W G, Wang Z Y, Chen J, Du Z F. 2005. Determination of multipesticide residues in fruits and vegetables by matrix solid-phase disperse and gas chromatography. Food Science, 7, 194–197.
Fernándezcruz M L, Villarroya M, Llanos S, Alonsoprados J L, Garcíabaudín J M. 2004. Field-incurred fenitrothion residues in kakis: Comparison of individual fruits, composite samples, and peeled and cooked fruits. Journal of Agricultural & Food Chemistry, 52, 860–863.
Gammoudi I, Raimbault V, Tarbague H, Moroté F, Grauby-Heywang C, Othmane A, Kalfat R, Moynet D, Rebière D, Dejous C. 2014. Enhanced bio-inspired microsensor based on microfluidic/bacteria/love wave hybrid structure for continuous control of heavy metals toxicity in liquid medium. Sensors & Actuators (B: Chemical), 198, 278–284.
Gebreslassie B H, Yuan Y, You F. 2012. Design under uncertainty of hydrocarbon biorefinery supply chains: Multiobjective stochastic programming models, decomposition algorithm, and a comparison between CVaR and downside risk. AICHE Journal, 58, 2155–2179.
Geng A J, Li F D, Li L X. 2007. The plant protection machinery and technology at home and abroad. Journal of Agricultural Mechanization Research, 4, 195–197.
Gogos A, Knauer K, Buchelib T D. 2012. Nanomaterials in plant protection and fertilization: Current state, foreseen applications, and research priorities. Journal of Agricultural & Food Chemistry, 60, 9781–9792.
Gonzálezrodríguez R M, Canchogrande B, Torradoagrasar A, Simalgándara J, Mazairapérez J. 2009. Evolution of tebuconazole residues through the winemaking process of Mencía grapes. Food Chemistry, 117, 529–537.
Gure A, Lara F J, Megersa N, Olmo-Iruela M D, García-Campaña A M. 2014. Dispersive liquid-liquid microextraction followed by capillary high-performance liquid chromatography for the determination of six sulfonylurea herbicides in fruit juices. Food Analytical Methods, 7, 1465–1473.
Greg A R, Kevin H P, Alex N S, Peter W G, Alan P P. 2005. Fate of pesticides during the winemaking process in relation to malolactic fermentation. Journal of Agricultural & Food Chemistry, 53, 3023–3026.
Han Y, Dong F, Xu J, Liu X, Li Y, Kong Z, Liang X, Liu N, Zheng Y. 2014. Residue change of pyridaben in apple samples during apple cider processing. Food Control, 37, 240–244.
He H P, Zhou J, Zhang C D, Ye L I, Huang J, Ding Y, Li T W, Su X R. 2013. Study on the detection of PCBs in seawater by chemical sensors. Oceanologia et Limnologia Sinica, 44, 1544–1549. (in Chinese)
He X K, Bonds J, Herbst A, Langenakens J. 2017. Recent development of unmanned aerial vehicle for plant protection in East Asia. International Journal of Agricultural & Biological Engineering, 10, 18–30.
Hua N Z. 2006. Development and advance of pesticides water dispersible granule formulations. Modern Agrochemicals, 2, 35–50.
Jia L. 2012. Application of electrochemical enzyme biosensor in environmental pollution monitoring. Progress in Chemistry, 24, 131–143.
Jia W, Chu X G, Zhang F. 2015. Multiresidue pesticide analysis in nutraceuticals from green tea extracts by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry. Journal of Chromatography (A), 1395,160–166.
Jiang M. 2000. Study and forecast on new optically active pesticides. Pesticides, 39, 1–3.
Jovanov P, Guzsvány V, Lazi? S, Franko M, Saka? M, Šari? L, Kos J. 2015. Development of HPLC-DAD method for determination of neonicotinoids in honey. Journal of Food Composition & Analysis, 40, 106–113.
Kabir M H, Abd El-Aty A M, Kim S W, Lee H S, Rahman M M, Lee Y J, Chung H S, Lieu T, Choi J H, Shin H C. 2016. Residual determination and risk assessment of buprofezin in plum (Prunus domestica) grown in open-field conditions following the application of three different formulations. Biomedical Chromatography, 30, 1721–1727.
Kah M, Hofmann T. 2014. Nanopesticide research: Current trends and future priorities. Environment International, 63, 224–235.
Kontou S, Tsipi D, Tzia C. 2004. Stability of the dithiocarbamate pesticide maneb in tomato homogenates during cold storage and thermal processing. Food Additives & Contaminants, 21, 1083–1089.
Lan Y B, Chen S D, Fritz B K. 2017. Current status and future trends of precision agricultural aviation technologies. International Journal of Agricultural & Biological Engineering, 10, 1–17.
Lan Y B, Thomson S J, Huang Y B, Hoffmann W C, Zhang H H. 2010. Current status and future directions of precision aerial application for site-specific crop management in the USA. Computers & Electronics in Agriculture, 74, 34–38.
Lentzarizos C, Balokas A. 2001. Residue levels of chlorpropham in individual tubers and composite samples of postharvest-treated potatoes. Journal of Agricultural & Food Chemistry, 49, 710–714.
Li H P, Li G C, Jen J F. 2013. Fast multi-residue screening for 84 pesticides in tea by gas chromatography with dual-tower auto-sampler, dual-column and dual detectors. Journal of the Chinese Chemical Society, 51, 531–542.
Li M, Liu X, Dong F, Xu J, Kong Z, Li Y, Zheng Y. 2013. Simultaneous determination of cyflumetofen and its main metabolite residues in samples of plant and animal origin using multi-walled carbon nanotubes in dispersive solid-phase extraction and ultrahigh performance liquid chromatography-tandem mass spectrome. Journal of Chromatography (A), 1300, 95–103.
Li X, Yuan S Y, Zhang M T, Yang S L. 2013. Advances in studies of pesticide pollution and its remediation technology. Agricultural Research & Application, 3, 47–50.
Li Y, Chu X, Zhong W, Li S, He Y. 2004. Determination of pesticides in unpolished rice by a combined approach of gel permeation chromatography and solid phase extraction purification and gas chromatography. Chinese Journal of Analytical Chemistry, 32, 1325–1328.
Li Y, Dong F, Liu X, Xu J, Li J, Kong Z, Chen X, Liang X, Zheng Y. 2012a. Simultaneous enantioselective determination of triazole fungicides in soil and water by chiral liquid chromatography/tandem mass spectrometry. Journal of Chromatography (A), 1224, 51–60.
Li Y, Dong F, Liu X, Xu J, Li J, Kong Z, Chen X, Zheng Y. 2012b. Environmental behavior of the chiral triazole fungicide fenbuconazole and its chiral metabolites: Enantioselective transformation and degradation in soils. Environmental Science & Technology, 46, 2675–2683.
Liao J, Ying Z, Zhou Z, Luo X. 2015. Quality evaluation method and optimization of operating parameters in crop aerial spraying technology. Transactions of the Chinese Society of Agricultural Engineering, 31, 38–46.
Liu F, Zhang X, Ma W, Liu X. 2010. Current Development status of foreign big-scale protection machinery and application technology. Journal of Agricultural Mechanization Research, 3, 246–248.
Liu F X, Song X F, Zou G Y, Fu Z S, Liu Y Q, Xue L H, Yang L Z. 2013. Reduce-retain-reuse-restore technology for the controlling the agricultural non-point source pollution in countryside in China: Eco-restoration technology. Journal of Agro-Environment Science, 32, 2105–2111.
Liu N, Dong F, Liu X, Xu J, Li Y, Han Y, Zhu Y, Cheng Y, Chen Z, Tao Y 2014. Effect of household canning on the distribution and reduction of thiophanate-methyl and its metabolite carbendazim residues in tomato. Food Control, 43, 115–120.
Liu W S, Zhu Z, Zhang X M, Chen Z, Lai F R. 2010. Study on removing organophosphorus pesticide residues from vegetable with four rinsing method. Modern Food Science & Technology, 26, 1395–1398.
Liu X, He B, Xu Z, Yin M, Yang W, Zhang H, Cao J, Shen J. 2015. A functionalized fluorescent dendrimer as a pesticide nanocarrier: Application in pest control. Nanoscale, 7, 445.
Liu Y, Tong Z, Prud’Homme R K. 2008. Stabilized polymeric nanoparticles for controlled and efficient release of bifenthrin. Pest Management Science, 64, 808–812.
Liu Y, Wang Z, Chu X. 2005. Determination of 50 organophosphorous pesticides in unpolished rice sample by gas chromatography-nitrogen phosphorous detecting with gel permeation chromatography clean-up. Chinese Journal of Analytical Chemistry, 33, 808–810. (in Chinese)
Liu Z, Liu S. 2015. Development of bioremediation in China - A review. Chinese Journal of Biotechnology, 31, 901–916. (in Chinese)
Naksen W, Prapamontol T, Mangklabruks A, Chantara S, Thavornyutikarn P, Robson M G, Ryan P B, Barr D B, Panuwet P. 2016. A single method for detecting 11 organophosphate pesticides in human plasma and breastmilk using GC-FPD. Journal of Chromatography (B: Analytical Technologies in the Biomedical & Life Sciences), 1025, 92–104.
National Bureau of Statistics of China. 2014a. National data of consumpation. [2016/09/29].
National Bureau of Statistics of China. 2014b. National data of output. [2016/09/29].
Pang G F, Chang Q Y, Fan C L. 2017. Prospect for research of pesticide residue monitoring technique and construction of monitoring systems. Bulletin of the Chinese Academy of Sciences, 10, 1083–1090.
Patel K, Fussell R J, Macarthur R, Goodall D M, Keely B J. 2004. Method validation of resistive heating - gas chromatography with flame photometric detection for the rapid screening of organophosphorus pesticides in fruit and vegetables. Journal of Chromatography (A), 1046, 225–234.
Physics C A. 2013. Fabrication and analytical application of three-dimensional paper-based microfluidics for rapid detection of nitrite. Food Science, 34, 341–345.
Ramshani Z, Reddy A S G, Narakathu B B, Wabeke J T, Obare S O, Atashbar M Z. 2015. SH-SAW sensor based microfluidic system for the detection of heavy metal compounds in liquid environments. Sensors & Actuators (B: Chemical), 217, 72–77.
Rasmusssen R R, Poulsen M E, Hansen H C. 2003. Distribution of multiple pesticide residues in apple segments after home processing. Food Additives & Contaminants, 20, 1044–1063.
Rejczak T, Tuzimski T. 2016. Simple, cost-effective and sensitive liquid chromatography diode array detector method for simultaneous determination of eight sulfonylurea herbicides in soya milk samples. Journal of Chromatography (A), 1473, 56–65.
Romeh A A, Mekky T M, Ramadan R A, Hendawi M Y. 2009. Dissipation of profenofos, imidacloprid and penconazole in tomato fruits and products. Bulletin of Environmental Contamination & Toxicology, 83, 812–817.
Sackmann E K, Fulton A L, Beebe D J. 2014. The present and future role of microfluidics in biomedical research. Nature, 507, 181–189.
Sandell L S. 1995. Water-dispersible Granular Agricultural Compositions Made by Heat Extrusion. U.S. Patent, Applicatio No. 5714157.1998-02-03.
Scheidt R A, Santini J T, Richards A C, Johnson A M. 2000. Microchips as implantable drug delivery devices. In: Microtechnologies in Medicine and Biology. pp. 483–486.
Scognamiglio V, Arduini F, Palleschi G, Rea G. 2014. Biosensing technology for sustainable food safety. TRAC Trends in Analytical Chemistry, 62, 1–10.
Shen C, Jia S, Tang Z, Zhou Y, Meng X, Yuan L. 2010. Research actuality and application prospects of pesticide electrostatic spraying. Journal of Agricultural Mechanization Research, 4, 16–19.
Sun C, Shu K, Wang W, Ye Z, Liu T, Gao Y, Zheng H, He G, Yin Y. 2014. Encapsulation and controlled release of hydrophilic pesticide in shell cross-linked nanocapsules containing aqueous core. International Journal of Pharmaceutics, 463, 108–114.
Sun J, Haitao L I, Xia H, Shixue L I. 2007. Pharmacoeconomics and “me-too” drug research and development. China Pharmacy, 35, 10–13. (in Chinese)
Waliszewski S M, Carvajal O, Infanzon R M, Trujillo P, Maxwell M. 2004. Levels of organochlorine pesticides in soils and rye plant tissues in a field study. Journal of Agricultural & Food Chemistry, 52, 7045–7050.
Wang C, Gao L Q. 2003. Electronic nose based atmosphere measuring and controllingsystem for thermal chemical treatment. Journal of Southeast University, 33, 442–445.
Wang C F, Chen F, Wei H, You Y, Xiu D M. 2005. Removing methods for beta-cypermethrin residue in contaminated vegetables. Journal of Agro-Environmental Science, 24, 1018–1021.
Wang C L. 2006. Electronic nose system for the recognition of pesticides based on the characteristic ratios method. Chinese Journal of Sensors & Actuators, 19, 573.
Wang C L, Huang W Y. 2003. The design of an artificial olfactory sytem. Industrial Instrumentation & Automation, 5, 61–64.
Wang C X, Cui B, Zeng Z H, Wang Y, Sun C J, Zhao X, Feng L, Liu G Q, Cui H X. 2017. Research progress on pesticide solid nanodispersion and its preparation methods. Journal of Agricultural Sciences and Technology, 19, 108–114.
Wang S Q, Meng J, Yan Z, Lei S, Pu C F, Shao H X. 2009. Effect of plasma on omethoate residue degradation in apple and Chinese cabbage. Transactions of the Chinese Society of Agricultural Engineering, 25, 318–323.
Wang Y, Feng X, Liu J, Liu W. 2015. Orchard wind to send sprayer fan blade modal analysis based on ANSYS workbench. Journal of Agricultural Mechanization Research, 3, 56–59.
Wang Y H, Wa M H, Zhang J S. 2007. Present situation on pesticide formulations. Agrochemicals, 5, 17–21.
Won S Y, Chang H L, Chang H S, Su O K, Sun H L, Dong S K. 2011. Monitoring of 14 sulfonamide antibiotic residues in marine products using HPLC-PDA and LC-MS/MS. Food Control, 22, 1101–1107.
Xiao Z, He M, Chen B, Hu B. 2016. Polydimethylsiloxane/metal-organic frameworks coated stir bar sorptive extraction coupled to gas chromatography-flame photometric detection for the determination of organophosphorus pesticides in environmental water samples. Talanta, 156, 126–133.
Xu J. 2014. Microfluidics “Lab-on-A-Chip” System for food chemical hazard detection. In: Wang S, ed., Food Chemical Hazard Detection. Wiley publisher, USA. pp. 263–289.
Xu M B, Yin Y, Yu H C. 2009. Feature extraction method for recognition of organophosphorus pesticides by electronic nose. Transducer & Microsystem Technologies, 28, 25–27.
Yager P, Edwards T, Fu E, Helton K, Nelson K, Tam M R, Weigl B H. 2006. Microfluidic diagnostic technologies for global public health. Nature, 442, 412–418.
Yang N, Mao H, Sun J, Xiang C, Xu P. 2015. A photometric method for organophosphorus pesticide detection based on microfluidic chip. Bulgarian Chemical Communications, 47, 1147–1154.
Yu H, Yi X, Yang G, Yu H. 2015. Ozone cooperated with ultrafiltration for the removal of pesticide residues from slight-polluted water. Technology of Water Treatment, 41, 110–113.
Zhang C Z, Luo A L, Wang D L, Liu X J. 2005. Degradation method of beta-cypermethrin residue on greengrocery. Journal of Agro-Environmental Science, 24, 196–200.
Zhang C Z, Zhang X M, Tian Z H, He D J, Liu X J. 2010. Degradation of chlorpyrifos and fipronil in rice from farm to fork and risk assessment. Journal of Integrative Agriculture, 9, 754–763.
Zhang D, Lan Y, Chen L, Xiu W, Dong L. 2014. Current status and future trends of agricultural aerial spraying technology in China. Transactions of the Chinese Society for Agricultural Machinery, 45, 53–59.
Zhang H F, Xu L. 2014. Summary of research status on orchard sprayer. Journal of Chinese Agricultural Mechanization, 35, 112–118.
Zhang Y, Lan Y, Bradley K, Xue X. 2016. Development of aerial electrostatic spraying systems in the United States and applications in China. Transactions of the Chinese Society of Agricultural Engineering, 32, 1–7.
Zhang Y B. 2006. Pesticide discovery methods - a review. Agrochemicals, 6, 7–10.
Zhao F, Wang H, Han X, Yang Z. 2016. Development and comparative study of chemosynthesized antigen and mimotope-based immunoassays for class-specific analysis of O,O-dimethyl organophosphorus pesticides. Scientific Reports, 6, 37640.
Zhao W X, Gong D X, Yang R B, Guo Z Y, Zou Y Z. 2005. Multiresidue determination of organophosphorous pesticides and organonitrogen pesticides in rice by gas chromatography. Food Science, 26, 183–186.
Zhou J, Yuan Y, Zhu Z, Yao C, Zhang G, Qi G. 2015. A review on bioremediation technologies of organic pollutants contaminated soils. Ecology & Environmental Sciences, 24, 343–351.
Zhou Q, Gao B Y, Zhang X, Xu Y, W, Shi H M, Yu L L. 2014. Chemical profiling of triacylglycerols and diacylglycerols in cow milk fat by ultra-performance convergence chromatography combined with a quadrupole time-of-flight mass spectrometry. Food Chemistry, 143, 199–204.
Zhou Z, Zang Y, Luo X, Lan Y, Xue X. 2013. Technology innovation development strategy on agricultural aviation industry for plant protection in China. Chinese Society of Agricultural Engineering, 29, 1–10.
Zhu Y, Liu X, Xu J, Dong F, Liang X, Li M, Duan L, Zheng Y. 2013. Simultaneous determination of spirotetramat and its four metabolites in fruits and vegetables using a modified quick, easy, cheap, effective, rugged, and safe method and liquid chromatography/tandem mass spectrometry. Journal of Chromatography (A), 1299, 71–77.
No related articles found!
No Suggested Reading articles found!