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Journal of Integrative Agriculture  2015, Vol. 14 Issue (9): 1673-1686    DOI: 10.1016/S2095-3119(14)60980-1
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The cytochrome P450 superfamily: Key players in plant development and defense
 XU Jun, WANG Xin-yu, GUO Wang-zhen
1、State Key Laboratory of Crop Genetics & Germplasm Enhancement, Hybrid Cotton R&D Engineering Research Center, Ministry
of Education/College of Agriculture, Nanjing Agricultural University, Nanjing 210095, P.R.China
2、College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, P.R.China
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摘要  The cytochrome P450 (CYP) superfamily is the largest enzymatic protein family in plants, and it also widely exists in mammals, fungi, bacteria, insects and so on. Members of this superfamily are involved in multiple metabolic pathways with distinct and complex functions, playing important roles in a vast array of reactions. As a result, numerous secondary metabolites are synthesized that function as growth and developmental signals or protect plants from various biotic and abiotic stresses. Here, we summarize the characterization of CYPs, as well as their phylogenetic classification. We also focus on recent advances in elucidating the roles of CYPs in mediating plant growth and development as well as biotic and abiotic stresses responses, providing insights into their potential utilization in plant breeding.

Abstract  The cytochrome P450 (CYP) superfamily is the largest enzymatic protein family in plants, and it also widely exists in mammals, fungi, bacteria, insects and so on. Members of this superfamily are involved in multiple metabolic pathways with distinct and complex functions, playing important roles in a vast array of reactions. As a result, numerous secondary metabolites are synthesized that function as growth and developmental signals or protect plants from various biotic and abiotic stresses. Here, we summarize the characterization of CYPs, as well as their phylogenetic classification. We also focus on recent advances in elucidating the roles of CYPs in mediating plant growth and development as well as biotic and abiotic stresses responses, providing insights into their potential utilization in plant breeding.
Keywords:  cytochrome P450       phylogenetic classification       plant growth and development       biotic and abiotic stress  
Received: 13 November 2014   Accepted: 05 September 2015

This work was financially supported in part by National Natural Science Foundation of China (31171590), and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (010-809001) and Jiangsu Collaborative Innovation Center for Modern Crop Production, China (No.10).

Corresponding Authors:  GUO Wang-zhen, Tel: +86-25-84396523,E-mail:     E-mail:
About author:  XU Jun, E-mail:;

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XU Jun, WANG Xin-yu, GUO Wang-zhen. 2015. The cytochrome P450 superfamily: Key players in plant development and defense. Journal of Integrative Agriculture, 14(9): 1673-1686.

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