关键词: 四肢骨骼, 全基因组扫描, QTL定位, 猪

Abstract:

【Objective】 The aim of this study was to detect quantitative trait loci (QTL) for the lengths and the diameters of porcine limb bones, the lengths and the diameters of femoral and humerus medulla antra and the thicknesses of the femoral and the humerus walls. 【Method】 Lengths of 29 limb bones, diameters of 6 limb bones, diameters and lengths of femoral and humerus medulla antra and the thicknesses of femoral and humerus walls were measured in a white Duroc × Erhualian intercross. A whole-genome scan was performed by an interval mapping based least-squares linear regression with 183 informative microsatellite markers. 【Result】 Fourteen 1% genome-wide significant QTL, Fourteen 5% genome-wide significant QTL and 47 suggestive QTL were detected for the 39 traits. Except for SSC11, QTL were identified for limb bones on all pig chromosomes. 【Conclusion】 Totally, 75 QTL for 39 traits of limb bones were mapped in this study. Many QTLs affecting limb bones growth were found at the 57-59 cM chromosome region of SSC7.

Key words: limb bones, whole genome scan, QTL, pig