Plant-parasitic nematodes cause substantial economic losses to global agriculture yearly.  The use of nematicides is an effective way of controlling plant-parasitic nematodes.  However, the long-term use of traditional organophosphorus and carbamate chemical nematicides can lead to increased nematode resistance.  With the increasing awareness of the necessity for the protection of the environment and human health, highly toxic nematicides no longer meet the developmental requirements of modern agriculture.  Recently, many studies have been undertaken on the isolation and nematicidal activity of natural products against plant-parasitic nematodes and Caenorhabditis elegans.  As an important model nematode, C. elegans plays a vital reference role in studying plant-parasitic nematodes regarding nematicidal activity, metabolic mechanism, and modes of action and target.  We reviewed the latest research progress of natural nematicidal active compounds against plant-parasitic nematodes and C. elegans over the past ten years, discussed the structure-activity relationship and mechanism of action, and examined the development and application of natural nematicidal active compounds.

Plant virus disease is one of the major causes of biological disasters in agriculture worldwide.  Given the complexity of transmission media and plant disease infection mechanisms, the prevention and control of plant viral diseases is a great challenge, and an efficient green pesticide is urgently needed.  For this reason, when developing candidate drug leads to regulate plant viruses, pesticide experts have focused on characteristics such as low pesticide resistance, eco-friendliness, and novel mechanism.  Researchers have also theoretically investigated the molecular targets of viruses infecting agricultural crops.  Antiviral screening models have been constructed based on these molecular targets, and the mechanisms of commercial drugs and high-activity compounds have been extensively investigated.  After screening, some compounds have been applied in the field and found to have good commercial prospects; these drugs may be used to create new green antiviral pesticides to control plant viruses.  This paper reviews the screening, mode of action, development and application of recently used plant-based antiviral agents.