Dynamic Change of Genetic Diversity in Conserved Populations with Different Initial Genetic Architectures

doi:10.1016/S2095-3119(13)60439-6

Journal of Integrative Agriculture ›› 2013, Vol. 12 ›› Issue (7): 1225-1233.DOI: 10.1016/S2095-3119(13)60439-6

Dynamic Change of Genetic Diversity in Conserved Populations with Different Initial Genetic Architectures

href="https://www.chinaagrisci.com/Jwk_zgnykxen/CN/article/advancedSearchResult.do?searchSQL=(((LU Yun-feng[Author]) AND 1[Journal]) AND year[Order])" target="_blank">LU Yun-feng, href="https://www.chinaagrisci.com/Jwk_zgnykxen/CN/article/advancedSearchResult.do?searchSQL=(((LI Hong-wei[Author]) AND 1[Journal]) AND year[Order])" target="_blank">LI Hong-wei, href="https://www.chinaagrisci.com/Jwk_zgnykxen/CN/article/advancedSearchResult.do?searchSQL=(((WU Ke-liang[Author]) AND 1[Journal]) AND year[Order])" target="_blank">WU Ke-liang, WU Chang-xin

1.College of Animal Science and Technology, China Agricultural University, Beijing 100193, P.R.China
2.School of Life Science and Technology, Nanyang Normal University, Nanyang 473061, P.R.China
3.National Engineering Laboratory for Animal Breeding, Beijing 100193, P.R.China

出版日期:2013-07-01 发布日期:2013-07-04
通讯作者: Correspondence WU Ke-liang, Tel/Fax: +86-10-62734767, E-mail: liangkwu@cau.edu.cn
作者简介:LU Yun-feng, E-mail: luyunfeng6@yahoo.com.cn;
基金资助:
This work was partly supported by the program for Changjiang Scholar and Innovation Research Team in University, China (IRT1191), the Beijing Science and Technology Project, China (Z080005022208015) and the Chinese Universities Scientific Fund (2012YJ058).

Dynamic Change of Genetic Diversity in Conserved Populations with Different Initial Genetic Architectures

LU Yun-feng, LI Hong-wei, WU Ke-liang, WU Chang-xin

1.College of Animal Science and Technology, China Agricultural University, Beijing 100193, P.R.China
2.School of Life Science and Technology, Nanyang Normal University, Nanyang 473061, P.R.China
3.National Engineering Laboratory for Animal Breeding, Beijing 100193, P.R.China

Online:2013-07-01 Published:2013-07-04
Contact: Correspondence WU Ke-liang, Tel/Fax: +86-10-62734767, E-mail: liangkwu@cau.edu.cn
About author:LU Yun-feng, E-mail: luyunfeng6@yahoo.com.cn;
Supported by:
This work was partly supported by the program for Changjiang Scholar and Innovation Research Team in University, China (IRT1191), the Beijing Science and Technology Project, China (Z080005022208015) and the Chinese Universities Scientific Fund (2012YJ058).

摘要/Abstract

摘要： Maintenance and management of genetic diversity of farm animal genetic resources (AnGR) is very important for biological, socioeconomical and cultural significance. The core concern of conservation for farm AnGR is the retention of genetic diversity of conserved populations in a long-term perspective. However, numerous factors may affect evolution of genetic diversity of a conserved population. Among those factors, the genetic architecture of conserved populations is little considered in current conservation strategies. In this study, we investigated the dynamic changes of genetic diversity of conserved populations with two scenarios on initial genetic architectures by computer simulation in which thirty polymorphic microsatellite loci were chosen to represent genetic architecture of the populations with observed heterozygosity (Ho) and expected heterozygosity (He), observed and mean effective number of alleles (Ao and Ae), number of polymorphic loci (NP) and the percentage of polymorphic loci (PP), number of rare alleles (RA) and number of non-rich polymorphic loci (NRP) as the estimates of genetic diversity. The two scenarios on genetic architecture were taken into account, namely, one conserved population with same allele frequency (AS) and another one with actual allele frequency (AA). The results showed that the magnitude of loss of genetic diversity is associated with genetic architecture of initial conserved population, the amplitude of genetic diversity decline in the context AS was more narrow extent than those in context AA, the ranges of decline of Ho and Ao were about 4 and 2 times in AA compared with that in AS, respectively, the occurrence of first monomorphic locus and the time of change of measure NP in scenario AA is 20 generations and 23 generations earlier than that in scenario AS, respectively. Additionally, we found that NRP, a novel measure proposed by our research group, was a proper estimate for monitoring the evolution of genetic diversity in a closed conserved population. Our study suggested that current managements of conserved populations should emphasize on initial genetic architecture in order to make an effective and feasible conservation scheme.

关键词: genetic diversity , genetic architecture , conservation , simulation

Abstract: Maintenance and management of genetic diversity of farm animal genetic resources (AnGR) is very important for biological, socioeconomical and cultural significance. The core concern of conservation for farm AnGR is the retention of genetic diversity of conserved populations in a long-term perspective. However, numerous factors may affect evolution of genetic diversity of a conserved population. Among those factors, the genetic architecture of conserved populations is little considered in current conservation strategies. In this study, we investigated the dynamic changes of genetic diversity of conserved populations with two scenarios on initial genetic architectures by computer simulation in which thirty polymorphic microsatellite loci were chosen to represent genetic architecture of the populations with observed heterozygosity (Ho) and expected heterozygosity (He), observed and mean effective number of alleles (Ao and Ae), number of polymorphic loci (NP) and the percentage of polymorphic loci (PP), number of rare alleles (RA) and number of non-rich polymorphic loci (NRP) as the estimates of genetic diversity. The two scenarios on genetic architecture were taken into account, namely, one conserved population with same allele frequency (AS) and another one with actual allele frequency (AA). The results showed that the magnitude of loss of genetic diversity is associated with genetic architecture of initial conserved population, the amplitude of genetic diversity decline in the context AS was more narrow extent than those in context AA, the ranges of decline of Ho and Ao were about 4 and 2 times in AA compared with that in AS, respectively, the occurrence of first monomorphic locus and the time of change of measure NP in scenario AA is 20 generations and 23 generations earlier than that in scenario AS, respectively. Additionally, we found that NRP, a novel measure proposed by our research group, was a proper estimate for monitoring the evolution of genetic diversity in a closed conserved population. Our study suggested that current managements of conserved populations should emphasize on initial genetic architecture in order to make an effective and feasible conservation scheme.

Key words: genetic diversity , genetic architecture , conservation , simulation

LU Yun-feng, LI Hong-wei, WU Ke-liang, WU Chang-xin. Dynamic Change of Genetic Diversity in Conserved Populations with Different Initial Genetic Architectures[J]. Journal of Integrative Agriculture, 2013, 12(7): 1225-1233.

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Dynamic Change of Genetic Diversity in Conserved Populations with Different Initial Genetic Architectures

Dynamic Change of Genetic Diversity in Conserved Populations with Different Initial Genetic Architectures

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