植物病原黄单胞菌DSF信号依赖的群体感应机制及调控网络

doi:10.3864/j.issn.0578-1752.2013.14.007

摘要/Abstract

摘要： 群体感应是微生物之间相互交流的一种重要联络方式，它协助细菌能感应群体密度从而调节基因表达。20世纪80年代以来，多种群体感应信号及其传导机制得以阐明。DSF（diffusible signal factor）是近年来在野油菜黄单胞菌中首先鉴定的1个新型群体感应信号，化学结构为顺式11?甲基?2?十二碳烯酸，其信号传导途径包括RpfC/RpfG双组分感应系统、二级信使环二鸟苷酸（c-di-GMP）、全局性转录因子Clp等。在野油菜黄单胞菌中，DSF群体感应信号调控3类生物学功能：一是促进致病相关基因的表达；二是抑制生物膜形成；三是促进黄单胞菌作出代谢调整，适应高群体密度环境。RpfF是DSF信号生物合成过程中的关键酶，黄单胞菌在高群体密度条件下通过一种新型自我诱导机制大量合成DSF。DSF信号不仅存在于所有黄单胞菌属细菌中，也广泛存在于苛养木杆菌、嗜麦芽寡养单胞菌、伯克氏菌、铜绿假单胞菌和许多海洋细菌中，其传导途径和生物学功能还有待进一步阐明。

关键词: 黄单胞菌 , 群体感应 , DSF

Abstract: It is now clear that quorum sensing (QS) is one of the most important cell-cell communications in bacteria and this community-wide genetic regulatory mechanism is involved in the regulation of many important biological activities. Since the 1980s, several types of QS signals have been identified. The diffusible signal factor (DSF)，which was originally identified in Xanthomonas campestris pv. campestris (Xcc), represents another interesting type of QS signals found in Gram-negative bacteria. The rapid progress over the last 10 years has identified the chemical structures of the QS signal DSF, established the DSF regulon, and unveiled the general signaling pathways and mechanisms. RpfF is a key enzyme for DSF biosynthesis, which is modulated by a novel autoinduction mechanism involving protein-protein interaction between the DSF synthase RpfF and the sensor RpfC. DSF signal is sensed by RpfC/RpfG two component system and the signal sensing is coupled to intracellular regulatory networks through a second messenger cyclic di-GMP and a global regulator Clp. Genomic and genetic analyses show that the DSF signal regulates diverse biological functions including virulence, biofilm dispersal, and ecological competence. Evidence is emerging that the DSF QS system is conserved in a range of plant and human bacterial pathogens.

Key words: Xanthomonas , quorum sensing , DSF

周莲, 王杏雨, 何亚文. 植物病原黄单胞菌DSF信号依赖的群体感应机制及调控网络[J]. 中国农业科学, 2013, 46(14): 2910-2922.

ZHOU Lian, WANG Xing-Yu, HE Ya-Wen. DSF Signal-Dependent Quorum Sensing in Plant Pathogenic Bacteria Xanthomonas[J]. Scientia Agricultura Sinica, 2013, 46(14): 2910-2922.

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