猪病毒性腹泻二联疫苗研究成果的回顾

中国农业科学

猪病毒性腹泻二联疫苗研究成果的回顾

马思奇

中国农业科学院哈尔滨兽医研究所，猪传染病研究室, 哈尔滨 150001

出版日期:2007-12-31 发布日期:2007-12-31
作者简介:马思奇（1930-），男，吉林大安人，研究员，研究方向为动物传染病防制。Tel：0451-85935073；E-mail：fl@ hvri.ac.cn
基金资助:
国家“八五”，“九五”科技攻关项目

Review of the Development of Bi-combined Vaccines Against Viral Diarrhea of Swine

MA Si-qi

Division of Swine Infectious Diseases, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001

Online:2007-12-31 Published:2007-12-31

摘要/Abstract

摘要： 本项研究包括TGE与PED二联灭活疫苗及二联弱毒疫苗，两个二联疫苗的主动免疫保护率分别为96%及97%，被动免疫保护率分别为84.7%和98%，主动免疫的免疫期为6～7个月，仔猪的被动免疫期是哺乳期至断奶后一周。用克隆纯化方法培育成弱毒株，新的免疫途径是后海穴位一次接种，经田间试验、区域性试验向全国推广应用后取得显著的社会经济效益，分别于1999年及2003年获农业部颁发的国家一类新兽药证书，是我国首创的具有自主知识产权的产品，于2004年获国家科技进步二等奖。

关键词: 猪传染性胃肠炎 , 猪流行性腹泻 , 二联疫苗

Abstract: The project consistes of bi-combined killed vaccine against transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV), bi-combined attenuated vaccine against TGEV and PEDV. The protective rate of active immunization of two bi-combined vaccines were 96% and 97.6%, respectively, and the protective rate of passive immunization of two bi-combined vaccines were 84.7% and 98%, respectively. The immunity duration of active immunization lasted 6-7 months, the immunity duration of passive immunization of piglets was from feeding duration to one week post-weaning. The attenuated strains were successfully cultivated by cloning and screening method. A novel immune route was one inoculation at Hou Hai point. After field trial and regional trial, two bi-combined vaccines were widely applied in the country and brought out striking economic benefit, acquired the new veterinary drug certificate of Ministry of Agriculture in 1999 and 2003, respectively. The two bi-combined vaccines were patent products, which had autonomic intellectual property rights. The bi-combined attenuated vaccine gained Second Class Prize of National Science and Technology Award in 2004.

Key words: TGE , PED , Bi-combined vaccine

马思奇. 猪病毒性腹泻二联疫苗研究成果的回顾[J]. 中国农业科学, 2007, 40(增刊): 3344-3349.

MA Si-qi. Review of the Development of Bi-combined Vaccines Against Viral Diarrhea of Swine[J]. Scientia Agricultura Sinica, 2007, 40(增刊): 3344-3349.

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