[1] ARTINGER S D C, LODDENKEMPER C, SCHWIMMBECK P L, SCHULTHEISS H P, PELS K. Complex porcine model of atherosclerosis: induction of early coronary lesions after long-term hyperlipidemia without sustained hyperglycemia. The Canadian Jouranal of Cardiology, 2009, 25(4): e109-114.
[2] WANG M D S. Human microbiota-associated swine: current progress and future opportunities. Institute for Laboratory Animal Research Journal, 2015, 56(1): 63-73.
[3] HOPKINS PN D J, FOUCHIER SW, BRUCKERT E, LUC G, CARIOU B, SJOUKE B, LEREN TP, HARADA-SHIBA M, MABUCHI H, RABÈS J P, CARRIÉ A, VAN HEYNINGEN C, CARREAU V, FARNIER M, TEOH Y P, BOURBON M, KAWASHIRI M A, NOHARA A, SORAN H, MARAIS A D, TADA H, ABIFADEL M, BOILEAU C, CHANU B, KATSUDA S, KISHIMOTO I, LAMBERT G, MAKINO H, MIYAMOTO Y, PICHELIN M, YAGI K, YAMAGISHI M, ZAIR Y, MELLIS S, YANCOPOULOS G D, STAHL N, MENDOZA J, DU Y, HAMON S, KREMPF M, SWERGOLD G D. Characterization of autosomal dominant hypercholesterolemia caused by PCSK9 gain of function mutations and its specific treatment with alirocumab, a PCSK9 monoclonal antibody. Circulation Cardiovascular Genetics, 2015, 8(6): 823-831.
[4] ETTCHETO M P D, PEDRÓS I, DE LEMOS L, PALLÀS M, ALEGRET M, LAGUNA J C, FOLCH J, CAMINS A. Hypercholesterolemia and neurodegeneration. Comparison of hippocampal phenotypes in LDLr knockout and APPswe/PS1dE9 mice. Experimental Gerontology, 2015, 65:69-78.
[5] ALVES A C E A, SOUTAR A K, MARTIN C, BOURBON M. Novel functional APOB mutations outside LDL-binding region causing familial hypercholesterolaemia. Human Molecular Genetics, 2014, 23(7): 1817-1828.
[6] ABIFADEL M V M, RABÈS JP, ALLARD D, OUGUERRAM K, DEVILLERS M, CRUAUD C, BENJANNET S, WICKHAM L, ERLICH D, DERRÉ A, VILLÉGER L, FARNIER M, BEUCLER I, BRUCKERT E, CHAMBAZ J, CHANU B, LECERF JM, LUC G, MOULIN P, WEISSENBACH J, PRAT A, KREMPF M, JUNIEN C, SEIDAH N G, BOILEAU C. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nature Genetics, 2003, 34(2): 154-156.
[7] MAXWELL K N, BRESLOW J L. Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proceeding of the National Academy of Sciences of th USA, 2004, 101(18): 7100-7105.
[8] MAXWELL K N, FISHER E A, BRESLOW J L. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post- endoplasmic reticulum compartment. Proceeding of the National Academy of Sciences of th USA, 2005, 102(6): 2069-2074.
[9] POIRIER S, HAMOUDA H A, VILLENEUVE L, DEMERS A, MAYER G. Trafficking dynamics of PCSK9-induced LDLR degradation: Focus on human PCSK9 mutations and C-terminal domain. PLoS One, 2016, 11(6): e0157230.
[10] HUMPHRIES S E, NEELY R D, WHITTALL R A, TROUTT J S, KONRAD R J, SCARTEZINI M, LI K W, COOPER J A, ACHARYA J, NEIL A. Healthy individuals carrying the PCSK9 p.R46L variant and familial hypercholesterolemia patients carrying PCSK9 p.D374Y exhibit lower plasma concentrations of PCSK9. Clinical Chemistry, 2009, 55(12): 2153-2161.
[11] Nguyen M A K T, Lagace T A. Internalized PCSK9 dissociates from recycling LDL receptors in PCSK9-resistant SV-589 fibroblasts. Journal of Lipid Research, 2014, 55(2): 266-275.
[12] Herbert B P D, Waddington S N, Eden E R, McAleenan A, Sun X M, Soutar A K. Increased secretion of lipoproteins in transgenic mice expressing human D374Y PCSK9 under physiological genetic control. Arterioscler Thromb Vasc Biol, 2010, 30(7): 1333-1339.
[13] Liu M, Wu G, Baysarowich J, Kavana M, Addona G H, Bierilo K K, Mudgett J S, Pavlovic G, Sitlani A, Renger J J, Hubbard B K, Fisher T S, Zerbinatti C V. PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain. Journal of lipid research, 2010, 51(9): 2611-2618.
[14] ROCHE-MOLINA M S-R D, CRUZ F M, GARCÍA-PRIETO J, LÓPEZ S, ABIA R, MURIANA F J, FUSTER V, IBÁÑEZ B, BERNAL J A. Induction of sustained hypercholesterolemia by single adeno-associated virus-mediated gene transfer of mutant hPCSK9. Arteriosclerosis Thrombosis and Vascular Biology, 2015, 35(1): 50-59.
[15] LAGACE T A C D, GARUTI R, MCNUTT M C, PARK S W, PRATHER H B, ANDERSON N N, HO Y K, HAMMER R E, HORTON J D. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. The Journal of Clinical Investigation, 2006, 116(11): 2995-3005.
[16] LUO Y W L, XIA D, JENSEN H, SAND T, PETRAS S, QIN W, MILLER K S, HAWKINS J. Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice. Journal of Lipid Research, 2009, 50(8): 1581-1588.
[17] DING Q, STRONG A, PATEL K M, NG S L, GOSIS B S, REGAN S N, COWAN C A, RADER D J, MUSUNURU K. Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing. Circulation Research, 2014, 115(5): 488-492.
[18] JENSEN TW M M, PETTIGEW J E, PEREZ-MENDOZA V G, ZACHARY J, SCHOOK L B. A cloned pig model for examining atherosclerosis induced by high fat, high cholesterol diets. Animal Biotechnology 2010, 21(3): 179-187.
[19] SHIM J A-M R, SØRENSEN C B, BENTZON J F. Large animal models of atherosclerosis-new tools for persistent problems in cardiovascular medicine. Journal of Pathology, 2016, 238(2): 257-266.
[20] Duran-Struuck R M A, Huang C A. Myeloid leukemias and virally induced lymphomas in miniature inbred Swine: Development of a large animal tumor model. Frontiers in Genetics, 2015, 6:332.
[21] 冯书堂. 中国实验用小型猪. 北京: 中国农业出版社, 2009.
FENG S T. Chinese Experimental Miniature Pig. Beijing: China Agriculture Press, 2009.(in Chinese)
[22] AL-MASHHADI R H, SORENSEN C B, KRAGH P M, CHRISTOFFERSEN C, MORTENSEN M B, TOLBOD L P, THIM T, DU Y T, LI J, LIU Y, MOLDT B, SCHMIDT M, VAJTA G, LARSEN T, PURUP S, BOLUND L, NIELSEN L B, CALLESEN H, FALK E, MIKKELSEN J G, BENTZON J F. Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant. Science translational medicine, 2013, 5(166): 166 rai.
[23] DAVIS B T, WANG X J, ROHRET J A, STRUZYNSKI J T, MERRICKS E P, BELLINGER D A, ROHRET F A, NICHOLS T C, ROGERS C S. Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs. PLoS One, 2014, 9(4): e93457.
[24] FANG X, M Y, HUANG Z, LI Y, HAN L, ZHANG Y, FENG Y, CHEN Y, JIANG X, ZHAO W, SUN X, XIONG Z, YANG L, LIU H, FAN D, MAO L, REN L, LIU C, WANG J, LI K, WANG G, YANG S, LAI L, ZHANG G, LI Y, WANG J, BOLUND L, YANG H, WANG J, FENG S, LI S, DU Y. The sequence and analysis of a Chinese pig genome. Gigascience, 2012, 1(1): 16.
[25] XIONG Y R Y, XU J, YANG D Y, HE X H, LUO J Y, RANA J S, ZHANG Y, ZHENG Z S, LIU D H, WU G F. Enhanced external counterpulsation inhibits endothelial apoptosis via modulation of BIRC2 and Apaf-1 genes in porcine hypercholesterolemia. International Journal of Cardiology, 2014, 171(2): 161-168.
[26] OGITA M M K, ONISHI A, TSUBOI S, WADA H, KONISHI H, NAITO R, DOHI T, KASAI T, KOJIMA Y, SCHWARTZ R S, DAIDA H. Development of accelerated coronary atherosclerosis model using low density lipoprotein receptor knock-out swine with balloon injury. PLoS One 2016, 11(9): e0163055.
[27] HAMAMDZIC D W R. Porcine models of accelerated coronary atherosclerosis: role of diabetes mellitus and hypercholesterolemia. Journal of Diabetes Research, 2013, 2013:c761415.
[28] POIRIER S, MAYER G, POUPON V, MCPHERSON P S, DESJARDINS R, LY K, ASSELIN M C, DAY R, DUCLOS F J, WITMER M, PARKER R, PRAT A, SEIDAH N G. Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route. The Journal of biological chemistry, 2009, 284(42): 28856-28864.
[29] PAUTA M, ROTLLAN N, VALES F, FERNANDEZ-HERNANDO A, ALLEN R M, FORD D A, MARI M, JIMENEZ W, BALDAN A, MORALES-RUIZ M, FERNANDEZ-HERNANDO C. Impaired liver regeneration in Ldlr-/-mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids. Journal of Hepatology, 2013, 59(4): 731-737.
[30] SUBRAMANIAN S, TURNER M S, DING Y, GOODSPEED L, WANG S, BUCKNER J H, O'BRIEN K, GETZ G S, REARDON C A, CHAIT A. Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice. Journal of Lipid Research, 2013, 54(10): 2831-2841. |