拟三元相图在25%氟菌•唑醚水乳剂配方筛选中的应用

doi:10.3864/j.issn.0578-1752.2013.22.008

中国农业科学 ›› 2013, Vol. 46 ›› Issue (22): 4707-4715.doi: 10.3864/j.issn.0578-1752.2013.22.008

拟三元相图在25%氟菌•唑醚水乳剂配方筛选中的应用

张鹏12, 黄啟良1, 王文桥2, 曹立冬1, 李凤敏1

1.中国农业科学院植物保护研究所/农业部作物有害生物综合治理重点实验室，北京 100193
2.河北省农林科学院植物保护研究所/河北省农业有害生物综合防治工程技术研究中心，河北保定 071000

收稿日期:2013-04-24 出版日期:2013-11-15 发布日期:2013-07-31
通讯作者: 通信作者黄啟良，Tel：010-62816909；E-mail：qlhuang@ippcaas.cn。通信作者王文桥，Tel：0312-5915659；E-mail：wenqiaow@163.com
作者简介:张鹏，Tel：15810195918；E-mail：pengz225@126.com
基金资助:
国家公益性行业（农业）科研专项（200903033、201003004）、国家科技支撑计划（2011BAE06B06-12、2012BAD19B06）

Application of Pseudo-Ternary Phase Diagram for Screening the Formula of 25% Fluopicolide•Pyraclostrobin EW

ZHANG Peng-12, HUANG Qi-Liang-1, WANG Wen-Qiao-2, CAO Li-Dong-1, LI Feng-Min-1

1.Institute of Plant Protection, Chinese Academy of Agricultural Sciences/Key Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Beijing 100193
2.Institute of Plant Protection, Hebei Academy of Agricultural & Forestry Sciences/IPM Center of Hebei Province, Baoding 071000, Hebei

Received:2013-04-24 Online:2013-11-15 Published:2013-07-31

摘要/Abstract

摘要： 【目的】探索拟三元相图在农药水乳剂配方筛选中的应用。【方法】在确定氟吡菌胺与吡唑醚菌酯混配比例的基础上，绘制含不同乳化剂的空白和含药拟三元相图，制备相应水乳剂样品并测定其相关质量指标，探索乳化剂种类和原药对相图中乳液区面积大小的影响以及相图中乳液区面积的大小对水乳剂样品稳定性的影响；通过观察相图绘制过程中相态转变和在相图中不同位置取点，加工水乳剂样品，测定其相关质量指标，明确加工水乳剂时乳化剂相的用量范围。【结果】虽不能单一地依靠相图中乳液区面积的大小筛选水乳剂的乳化剂，但形成乳液区面积大的乳化剂相对更适合加工水乳剂；SAA相用量与实际配方中油相含量有关，通常SAA相与油相的比值在0.11—0.25的范围内容易加工出稳定的水乳剂；合适的乳化剂与助乳化剂的比例有利于提高乳化效果；有机膨润土和黄原胶配合使用可增强该水乳剂的物理稳定性。【结论】利用拟三元相图法能够方便快捷地确定水乳剂的乳化剂种类与用量范围，对水乳剂配方筛选具有指导作用。

关键词: 水乳剂 , 配方筛选 , 拟三元相图 , 氟吡菌胺 , 吡唑醚菌酯

Abstract: 【Objective】The objective of this study is to explore the application of pseudo-ternary phase diagram for screening the formula of emulsion in water (EW). 【Method】 Blank and drug-containing pseudo-ternary phase diagrams were drew and corresponding samples were prepared and their quality indexes were determined on the basis of the mixing ratio of fluopicolide and pyraclostrobin was confirmed. The effect of the types of emulsifiers and technical materials on the size of the emulsion area in phase diagram and the effect of the size of the emulsion area in phase diagram on the stability of the EW samples were explored. The range of dosage of emulsifiers to processing EW were defined by the way of observing the change of phase states and determining the quality indexes of the samples which were processed by screening different points from the pseudo-ternary phase diagram.【Result】The results demonstrated that though the emulsifiers of EW couldn’t be screened only according to the area of the emulsion area in pseudo-ternary phase diagram, the emulsifiers which formed bigger emulsion area in pseudo-ternary phase diagram were more suitable for EW processing. The content of SAA phase in EW had relations with the content of oil phase in practical formula and usually the ratios of SAA phase and oil phase ranged from 0.11 to 0.25 were more likely to processing out of stable EW. Suitable emulsifier dosage was helpful to reduce particle size of emulsion and improve stability of EW samples. In alliance with Xanthan gum, the use of organic bentonite could enhance the physical stability of the fluopicolide•pyraclostrobin EW. 【Conclusion】The method of pseudo-ternary phase diagram can define the types and dosages of emulsifiers which is suitable for EW processing quickly and conveniently and has guiding function to the formula screening of EW.

Key words: emulsion in water (EW) , formula screening , pseudo-ternary phase diagram , fluopicolide , pyraclostrobin

张鹏12, 黄啟良1, 王文桥2, 曹立冬1, 李凤敏1. 拟三元相图在25%氟菌•唑醚水乳剂配方筛选中的应用[J]. 中国农业科学, 2013, 46(22): 4707-4715.

ZHANG Peng-12, HUANG Qi-Liang-1, WANG Wen-Qiao-2, CAO Li-Dong-1, LI Feng-Min-1. Application of Pseudo-Ternary Phase Diagram for Screening the Formula of 25% Fluopicolide•Pyraclostrobin EW[J]. Scientia Agricultura Sinica, 2013, 46(22): 4707-4715.

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拟三元相图在25%氟菌•唑醚水乳剂配方筛选中的应用

Application of Pseudo-Ternary Phase Diagram for Screening the Formula of 25% Fluopicolide•Pyraclostrobin EW

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