关键词: 水乳剂 , 配方筛选 , 拟三元相图 , 氟吡菌胺 , 吡唑醚菌酯

Abstract: 【Objective】The objective of this study is to explore the application of pseudo-ternary phase diagram for screening the formula of emulsion in water (EW). 【Method】 Blank and drug-containing pseudo-ternary phase diagrams were drew and corresponding samples were prepared and their quality indexes were determined on the basis of the mixing ratio of fluopicolide and pyraclostrobin was confirmed. The effect of the types of emulsifiers and technical materials on the size of the emulsion area in phase diagram and the effect of the size of the emulsion area in phase diagram on the stability of the EW samples were explored. The range of dosage of emulsifiers to processing EW were defined by the way of observing the change of phase states and determining the quality indexes of the samples which were processed by screening different points from the pseudo-ternary phase diagram.【Result】The results demonstrated that though the emulsifiers of EW couldn’t be screened only according to the area of the emulsion area in pseudo-ternary phase diagram, the emulsifiers which formed bigger emulsion area in pseudo-ternary phase diagram were more suitable for EW processing. The content of SAA phase in EW had relations with the content of oil phase in practical formula and usually the ratios of SAA phase and oil phase ranged from 0.11 to 0.25 were more likely to processing out of stable EW. Suitable emulsifier dosage was helpful to reduce particle size of emulsion and improve stability of EW samples. In alliance with Xanthan gum, the use of organic bentonite could enhance the physical stability of the fluopicolide•pyraclostrobin EW. 【Conclusion】The method of pseudo-ternary phase diagram can define the types and dosages of emulsifiers which is suitable for EW processing quickly and conveniently and has guiding function to the formula screening of EW.

Key words: emulsion in water (EW) , formula screening , pseudo-ternary phase diagram , fluopicolide , pyraclostrobin