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The toxicological effect of dietary excess of saccharicterpenin, the extract of camellia seed meal, in piglets
WANG Man, YU Bing, HE Jun, YU Jie, LUO Yu-heng, LUO Jun-qiu, MAO Xiang-bin, CHEN Dai-wen
2020, 19 (
1
): 211-224. DOI:
10.1016/S2095-3119(19)62789-9
Abstract
(
127
)
PDF in ScienceDirect
Recently, saccharicterpenin extracted from
Camellia oleifera
seed meal has become a widely used feed supplement in animal husbandry. In order to assess its safety, this study was designed to investigate the toxicity and histopathological effects of saccharicterpenin on piglets. One hundred-fifty weaned pigs ((Yorkshire×Landrace)×Duroc), 75 males and 75 females with body weight (BW) of (7.35±0.29) kg, were randomly allotted to groups receiving diets supplemented with 0, 500, 1 000, 2 500 or 5 000 mg kg
–1
saccharicterpenin for 70 d. The diet with 500 mg kg
–1
saccharicterpenin supplementation improved liver glutathione peroxidase (GSH-Px) activity, and the diet with 1 000 mg kg
–1
saccharicterpenin supplementation improved liver glutathione S-transferase (GSH-S) activity in piglets on d 70 (
P
<0.05). At 2 500 mg kg
–1
, saccharicterpenin in the diets reduced average daily feed intake (ADFI) and average daily gain (ADG) of piglets from d 1 to 35, damaged the cardiac tissue and liver on d 35, and decreased white blood cell counts (WBC), activities of catalase (CAT) and GSH-Px, and concentrations of glucose (GLU) and urea nitrogen (BUN) in the blood of piglets on d 70 (
P
<0.05). In addition, diets with 5 000 mg kg
–1
saccharicterpenin supplementation reduced ADFI, ADG and increased diarrhea rates of piglets from d 36 to 70, and decreased hemoglobin (HGB) concentration and activity of CAT in the blood of piglets on d 70 (
P
<0.05). Moreover, at a rate of 5 000 mg kg
–1
, saccharicterpenin supplementation increased pancreas index on d 35 and hepatic index on d 70, and damaged cardiac tissue, liver and spleen during the whole experimental period (
P
<0.05). These results suggested that dietary 500 mg kg
–1
saccharicterpenin supplementation had beneficial effects on piglets, but excessive supplementation
(2 500 or 5 000 mg kg
–1
) of saccharicterpenin in the diets could lead to growth retardation, hematological abnormalities and organ injuries.
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Effect of dietary supplementation with mulberry (
Morus alba
L.) leaves on the growth performance, meat quality and antioxidative capacity of finishing pigs
ZENG Zhu, JIANG Jun-jie, YU Jie, MAO Xiang-bing, YU Bing, CHEN Dai-wen
2019, 18 (
1
): 143-151. DOI:
10.1016/S2095-3119(18)62072-6
Abstract
(
311
)
PDF in ScienceDirect
The present study was conducted to evaluate the effect of dietary mulberry (
Morus alba
L.) leaves powder (MLP) supplementation on meat quality of finishing pigs. A total of 40 Duroc×Landrace×Yorkshire pigs (initial body weight of (40.5±0.63) kg) were randomly allotted into two treatments, fed either with control diet or 15% MLP diet for 85 d. The results showed that MLP diet decreased (
P
≤0.05) average daily gain (ADG) and increased (
P
<0.05) feed/gain ratio (F/G) in the finishing and whole period. MLP diet also decreased (
P
<0.05) carcass weight, dressing percentage, last rib and average backfat depth. However, MLP diet increased (
P
<0.05) intramuscular fat (IMF) content, decreased (
P
<0.05) shear force, cooking loss and drip loss. In addition, MLP diet increased (
P
<0.05) total antioxidative capacity, glutathione peroxidase and tended (
P
<0.10) to increase total superoxide dismutase in serum. In
longissimus thoracis
, myosin heavy chain (MyHC) I and IIa mRNA levels were increased (
P
≤0.05) for MLP diet. In conclusion, 15% MLP supplementation reduced the growth performance and carcass traits, but improved meat quality of finishing pigs possibly through the change of myofiber characteristics, enhancement of antioxidative capacity and increase of IMF.
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Effect of Dietary Folic Acid Supplementation on Growth Performance and Hepatic Protein Metabolism in Early-Weaned Intrauterine Growth Retardation Piglets
YAO Ying, YU Bing, CHEN Dai-wen, TIAN Gang, MAO Xiang-bing, ZHENG Ping, , LIUJing-bo
2013, 12 (
5
): 862-868. DOI:
10.1016/S2095-3119(13)60262-2
Abstract
(
1565
)
PDF in ScienceDirect
To investigate the effects of dietary supplementation with folic acid on growth performance, hepatic protein metabolism and serum biochemical indices of early-weaned intrauterine growth retardation (IUGR) piglets, 24 male (Duroc× (Landrace×Yorkshire)) weaned (14-d-old) IUGR piglets were randomly divided into 3 treatments with 8 replicates of 1 piglet per replicate. The piglets in each treatment were fed basal diet supplementation with either 0 (control), 5 and 10 mg kg-1 folic acid. The trial lasted for 21 d. Dietary folic acid supplementation reduced average daily feed intake (ADFI) (P<0.05). In addition, the average daily gain (ADG) in 10 mg kg-1 folic acid group was significantly decreased (P<0.01) and the ratio of feed:gain (F/G) increased slightly (P>0.05). Serum folic acid concentration increased (P<0.01) with increasing folic acid inclusion, however, serum homocysteine concentration decreased significantly (P<0.01). Enhanced serum urine nitrogen (SUN) and diminished serum total protein (TP) as well as liver TP content were observed in 10 mg kg-1 folic acid group (P<0.05). Furthermore, the relative mRNA expressions of insulin-like growth factor 1 (IGF-1) and mammalian target of rapamycin (m-TOR) in liver were respectively tended to reduce (P=0.06) and significantly downregulated (P<0.05) in 10 mg kg-1 group, in compared with 5 mg kg-1 group. However, when compared with control group, folic acid supplementation had no significant effect on the mRNA abundance of IGF-1 and m-TOR. The results indicated that supplementation with 10 mg kg-1 folic acid impaired growth performance and hepatic protein metabolism of early-weaned IUGR piglets while 5 mg kg-1 folic acid enriched diet exerted limited positive effects.
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