关键词: 鸭源呼肠孤病毒')">鸭源呼肠孤病毒, 病理变化, 免疫损伤, 免疫抑制

Abstract:

【Objective】 The pathological damages of spleen and bursa of Fabricius in ducklings caused by duck-deprived reovirus and related immune index were observed. The mechanisms of immune organ damage and immune suppression upon duck-derived reovirus infection were studied for providing a theoretical basis for further studies on pathogenesis and immune prevention and control. 【Method】 Cherry Valley ducklings at 7-day old of age were artificially infected with duck-derived reovirus, then histopathological changes of spleen and bursa of Fabricius were observed. Spleen and bursa index, the positive rate of CD3+, CD8+ T cells in peripheral blood,and IgY-producing cells of spleen and bursa of Fabricius were detected. A significant difference between experimental and control group was analyzed. 【Result】 After the infection of duck-derived reovirus, notable necrosis was found in duckling spleen, followed by granuloma structure, and lymphoid follicles on lamina propia decreased significantly. The spleen and bursa indexes were reduced. The positive rate of CD3+, CD8+ T cells in peripheral blood also decreased. IgY -producing cells increased in spleen but decreased in bursa of Fabricius. 【Conclusion】 Duckling-origined reovirus infection may lead to severe injury of the ducklings immune organs and induce mmune suppression.

Key words: duck-derived reovirus')">duck-derived reovirus, pathology change, immune injury, immune suppression