Creatine Pyruvate Enhances Lipolysis and Protein Synthesis in Broiler Chicken

doi:10.1016/S1671-2927(11)60199-5

Journal of Integrative Agriculture ›› 2011, Vol. 10 ›› Issue (12): 1977-1985.DOI: 10.1016/S1671-2927(11)60199-5

Creatine Pyruvate Enhances Lipolysis and Protein Synthesis in Broiler Chicken

CHEN Juan, MA Hai-tian, WANG Man, KONG Yi-li , ZOU Si-xiang

1.Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095,P.R.China

收稿日期:2010-11-16 出版日期:2011-12-01 发布日期:2011-12-19
通讯作者: Correspondence ZOU Si-xiang, Tel: +86-25-84396763, Fax: +86-25-84398669, E-mail:sixiangzou@njau.edu.cn
作者简介:CHEN Juan, Mobile: 13221008997, E-mail: 2008207014@njau.edu.cn
基金资助:
This research was supported by the the National Natural Science Foundation of China (30600439).

Creatine Pyruvate Enhances Lipolysis and Protein Synthesis in Broiler Chicken

CHEN Juan, MA Hai-tian, WANG Man, KONG Yi-li , ZOU Si-xiang

1.Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095,P.R.China

Received:2010-11-16 Online:2011-12-01 Published:2011-12-19
Contact: Correspondence ZOU Si-xiang, Tel: +86-25-84396763, Fax: +86-25-84398669, E-mail:sixiangzou@njau.edu.cn
About author:CHEN Juan, Mobile: 13221008997, E-mail: 2008207014@njau.edu.cn
Supported by:
This research was supported by the the National Natural Science Foundation of China (30600439).

摘要/Abstract

摘要： To assess the effects of creatine pyruvate (Cr-Pyr) on lipid and protein metabolism in broiler chickens, a total of 400 1-day-old male birds (Aconred) were randomly allocated to four groups, with each group replicating four times and each replicate involving 25 birds. The broilers were provided with a commercial diet supplemented with Cr-Pyr at 0, 1, 5, or 10% of the diet, respectively, for a period of 3 wk ad libitum (from 22 to 42 d). In the present study, body weight (BW) and average daily gain (ADG) of broilers decreased in 10% Cr-Pyr group (P<0.01), whereas the relative leg and pectoral muscle weights were significantly higher than they were in the control group (P<0.05). 5 or 10% Cr-Pyr of diets decreased the abdominal fat rate (AFR, abdominal fat/live weight) of the broilers. The serum or hepatic triglyceride (TG) concentrations were significantly lower in the 5 and 10% groups (P<0.01). In contrast, Cr-Pyr caused a marked increase in the serum nonesterified fatty acid (NEFA), high-density lipoprotein cholesterol (HDL-C) and creatine kinase (CK) concentrations (P<0.01). Supplementation with Cr-Pyr (5 and 10%) in the diet also increased glucagons (GLU), insulin (INS) or leptin (LEP) contents (P<0.01). The expression of hepatic peroxisomal proliferators-activated receptor α (PPAR-α) and carnitine palmitoyl transferase-I (CPT-I), muscle insulin-like growth factor I (IGF-I) were significantly elevated and myostatin mRNA level was reduced in the 5 and 10% groups (P<0.05). It was found that supplementation with 5% Cr-Pyr improves both lipid and protein metabolism by regulating various metabolic parameters of broilers, while not adversely affects growth performance in broiler chickens.

关键词: creatine pyruvate (Cr-Pyr), lipid metabolism, protein metabolism, liver, muscle, broiler chickens

Abstract: To assess the effects of creatine pyruvate (Cr-Pyr) on lipid and protein metabolism in broiler chickens, a total of 400 1-day-old male birds (Aconred) were randomly allocated to four groups, with each group replicating four times and each replicate involving 25 birds. The broilers were provided with a commercial diet supplemented with Cr-Pyr at 0, 1, 5, or 10% of the diet, respectively, for a period of 3 wk ad libitum (from 22 to 42 d). In the present study, body weight (BW) and average daily gain (ADG) of broilers decreased in 10% Cr-Pyr group (P<0.01), whereas the relative leg and pectoral muscle weights were significantly higher than they were in the control group (P<0.05). 5 or 10% Cr-Pyr of diets decreased the abdominal fat rate (AFR, abdominal fat/live weight) of the broilers. The serum or hepatic triglyceride (TG) concentrations were significantly lower in the 5 and 10% groups (P<0.01). In contrast, Cr-Pyr caused a marked increase in the serum nonesterified fatty acid (NEFA), high-density lipoprotein cholesterol (HDL-C) and creatine kinase (CK) concentrations (P<0.01). Supplementation with Cr-Pyr (5 and 10%) in the diet also increased glucagons (GLU), insulin (INS) or leptin (LEP) contents (P<0.01). The expression of hepatic peroxisomal proliferators-activated receptor α (PPAR-α) and carnitine palmitoyl transferase-I (CPT-I), muscle insulin-like growth factor I (IGF-I) were significantly elevated and myostatin mRNA level was reduced in the 5 and 10% groups (P<0.05). It was found that supplementation with 5% Cr-Pyr improves both lipid and protein metabolism by regulating various metabolic parameters of broilers, while not adversely affects growth performance in broiler chickens.

Key words: creatine pyruvate (Cr-Pyr), lipid metabolism, protein metabolism, liver, muscle, broiler chickens

CHEN Juan, MA Hai-tian, WANG Man, KONG Yi-li , ZOU Si-xiang. Creatine Pyruvate Enhances Lipolysis and Protein Synthesis in Broiler Chicken[J]. Journal of Integrative Agriculture, 2011, 10(12): 1977-1985.

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Creatine Pyruvate Enhances Lipolysis and Protein Synthesis in Broiler Chicken

Creatine Pyruvate Enhances Lipolysis and Protein Synthesis in Broiler Chicken

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