[1]Chen K M, Ge B F, Ma H P, Liu X Y, Ba M H, Wang Y. 2005.Icarlin, a flavonoid from the herb Epimedium enhancesthe osteogenic differentiation of rat primary bone marrowstromal cells. Pharmazie, 60, 939-942[2]Chen Z W, Xu H Y, Liu Z M, Zhu B D. 2008. Effect offormula granule of Siwu drugs on hematopoiesisfunction in bone marrow depression mice. ChinaOccupational Medicine, 35, 207-208 (in Chinese)[3]Chung B H, Kim J D, Kim C K, Kim J H, Won M H, Lee H S,Dong M S, Ha K S, Kwon Y G, Kim Y M. 2008. Icariinstimulates angiogenesis by activating the MEK/ERKandPI3K/Akt/eNOS-dependent signal pathways inhuman endothelial cells. Biochemical and BiophysicalResearch Communications, 376, 404-408[4]Ding L, Liang X G, Hu Y, Zhu D Y, Lou Y J 2008. Involvementof p38MAPK and reactive oxygen species in icariininducedcardiomyocyte differentiation of murineembryonic stem cells in vitro. Stem Cells andDevelopment, 17, 751-760[5]Fang S Q, Lu Z X. 2011. Advance in the research on biogicalfunction of microRNA-21 and relationship betweenmicroRNA-21 and cancer Journal of MolecularDiagnosis and Therapy, 3, 428-432. (in Chinese)[6]Guo H L, Zhao Y F, Wang X, Xu Y, Zhan H S. 2011.Experimental study on the mechanism of icariinimproving human osteoblasts proliferation and theexpression of OPG protein. China Journal ofOrthopaedics and Traumatology, 24, 585-588 (in Chinese)[7]He F, He Z Y, Li L, Qin X, Deng S M, Liu F. 2011. Protectiveeffects of bone marrow mesenchymal stem cells withstable expression of Bcl-2 on ischemia-hypoxia ofhippocampal neurons Scientific Research and Essays,6, 2763-2770[8]He Y Y, Shi Y F, Xiao Z Y, Wu G, Chen Y J. 2010. Theresearch of proliferation and migration of hepatic cellularcarcinoma cells SK-HEP-1 promoted by miR-21 Journalof Digestive Oncology (Electronic Version), 2, 21-24 (in Chinese)[9]Huang T H, Wu F T, Loeb G B, Hsu R, Heidersbach A,Brincat A, Horiuchi D, Lebbink R J, Mo Y Y, Goga A, etal. 2009. Up-regulation of miR-21 by HER2/neu signalingpromotes cell invasion Journal of BiologicalChemistry, 284, 18515-18524[10]Koizumi H, Yu J, Hashimoto R, Ouchi Y, Okabe T. 2010.Involvement of androgen receptor in nitric oxideproduction induced by icariin in human umbilical veinendothelial cells. FEBS Letter, 584, 2440-2444[11]Li D D, Xu J, Zhang Z G, Zhao Z, Zhao J, Xiang R K, Liu XR, Gao J M. 2008. Effects of three Chinese traditiionalmedicine monomer on cells number and cell apoptosisof blastocysts in porcine parthenogenetic embryos. In:Proceedings of the 14th Symposium of AnimalReproductive Branch of Chinese Association of AnimalScience and Veterinary Medicine. Qingdao, China. pp.427-429 (in Chinese)[12]Li T, Li D, Sha J J, Sun P, Huang Y R. 2009. MicroRNA-21directly targets MARCKS and promotes apoptosisresistance and invasion in prostate cancer cells Biochemical and Biophysical Research Communications, 383, 280-285[13]Liu B J, Zhang H Y, Xu C Q, Yang G, Tao J, Huang J H, WuJ F, Duan X H, Cao Y X, Dong J C. 2011. Neuroprotectiveeffects of icariin on corticosterone-induced apoptosisin primary cultured rat hippocampal neurons. BrainResearch, 1375, 59-67[14]Liu C Z, Yu J, Yu S N, Robert M L, Cai L, Liu W, Yang K G,He X D, Chen S S. 2010. MicroRNA-21 acts as anoncomir through multiple targets in humanhepatocellular carcinoma Journal of Hepatology, 53 ,98-107[15]Liu Z Q, Luo X Y, Sun Y X, Wu W, Liu C M, Liu Z Q, Liu SY. 2004. The antioxidative effect of icariin in humanerythrocytes against free-radical-induced haemolysis.Journal of Pharmacy and Pharmacology, 56, 1557-1562[16]Markou A, Tsaroucha E G, Kaklamanis L, Fotinou M,Georgoulias V, Lianidou E S. 2008. Prognostic value ofmature microRNA-21 and microRNA-205overexpression in non-small cell lung cancer byquantitative real-time RT-PCR Clinical Chemistry, 54,1696-1740[17]Meng F Y, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. 2007. MicroRNA-21 regulates expression ofthe PTEN tumor suppressor gene in humanhepatocellular cancer Gastroenterology, 133, 647-658[18]Meng L J, Gao J M, Liu Y H, Liu L Q, Zhang J F. 2008. Studyon assessment of blastocysts in vivo and in vitro bydifferential staining in mouse. Chinese Journal ofAnimal Science, 44, 49-51[19](in Chinese)Ming L G, Chen K M, Ge B F, Ma H P, Zhou J. 2011.Comparative study on effect of icariin and genistein onproliferation and mineralization of osteoblasts in vitro.China Journal of Chinese Materia Medica, 36, 2240-2245 (in Chinese)[20]Ren J, Tang L M. 2012. Research progress of microRNA incancers. Medical Recapitulate, 18, 1170-1173 (in Chinese)[21]Schetter A J, Leung S Y, Sohn J J, Zanetti K A, Bowman ED, Yanaihara N, Yuen S T, Chan T L, Kwong D L W, AuG K H, et al. 2008. MicroRNA expression profilesassociated with prognosis and therapeutic outcome incolon adenocarcinoma. Journal of the AmericanMedical Association, 299, 425-436[22]Schramedei K, Moerbt N, Pfeifer G, Laeuter J, RosolowskiM, Tomm J M, von Bergen M, Horn F, Brocke-HeidrichK. 2011. MicroRNA-21 targets tumor suppressor genesANP32A and SMARCA4 Oncogene, 30, 2975-2985[23]Shen X H, Han Y J, Zhang D X, Cui X S, Kim N H. 2009. Alink between the interleukin-6/Stat3 anti-apoptoticpathway and microRNA-21 in preimplantation mouseembryos Molecular Reproduction & Development,76 , 854-862[24]Si M L, Zhu S, Wu H, Lu Z, Wu F, Mo Y Y. 2007. MiR-21-mediated tumor growth Oncogene, 26, 2799-2803[25]Sun X D, Sun X W, Jin X D, Zhang X L, Liu C L, Lei L, JinL H, Liu H W. 2011. Icariin induces mouse embryonicstem cell differentiation into beating functionalc a r d i o m y o c y t e s . M o l e c u l a r a n d C e l l u l a rBiochemistry, 249, 117-123[26]Wang Y K, Huang Z Q. 2005. Protective effects of icariinon human umbilical vein endothelial cell injury inducedby H2O2 in vitro. Pharmacological Research, 52, 174-182[27]Wo Y B, Zhu D Y, Yu Y P, Lou Y J. 2008. Involvement of NFkBand AP-1 activation in icariin promoted cardiacdifferentiation of mouse embryonic stem cells European Journal of Pharmacology, 586, 59-66[28]Xiang R K, Mu X, Zhao J, Wu B, Liu X R, Zhang T, Gao JM. 2010. Study on icariin inducing mouse embryonicstem cells to differentiate into cardiomyogenic cells. Acta Veterinaria et Zootechnica Sinica, 41, 811-815(in Chinese)[29]Xie A, Li S W, Li L, Kuang L. 2011. Effects of cistanche andepimedium on development of early muse ebryo. ActaAgriculturae Universitatis Jiangxiensis, 33, 955-959(in Chinese)[30]Xu J, Li D D, Zhang Z G, Liu X R, Zhao Z, Zhao J, Xiang RK, Gao J M. 2009. Effects of three kinds of Chinesemedicine simplex components on porcineparthenogenetic embryos development in vitro. ChinaAnimal Husbandry & Veterinary Medicine, 36, 112-115 (in Chinese)[31]Yang L, Zhang L H, Zhou Y. 2007. Influence of Dangguibuxue tang on the prolifer ation of bone marrow cells ofmice. Journal of Clinical Rehabilitative TissueEngineering Research, 11, 538-539[32](in Chinese)Zhang D W, Cheng Y, Wang N L, Zhang J C, Yang M S,Yao X S. 2008. Effects of total flavonoids and flavonolglycosides from Epimedium koreanum Nakai on theproliferation and differentiation of primary osteoblasts.Phytomedicine, 15, 55-61[33]Zhang L X, Tang D F, Xu Y H, Liu Z Y, Zheng Y H. 2011.The relationship between tumor suppressor gene PTEN,its protein expression and the initiation growthapoptosis of primordial follicle. Reproduction &Contraception, 31, 323-328 (in Chinese)[34]Zhao F, Tang Y Z, Liu Z Q. 2007. Protective effect of icariinon DNA against radical-induced oxidative damage.Journal of Pharmacy and Pharmacology, 59, 1729-1732[35]Zhao J, Xiang R K, Xu J, Zhao Z, Wu B, Liu X R, Zhang YH, Gao J M. 2010. Effects of icariin on the level of NOand malondialdehyde during development of porcincein vitro fertilization early embryos. Acta AnatomicaSinica, 41, 636-638 (in Chinese)[36]Zhu S M, Wu H L, Wu F T, Nie D T, Sheng S J, Mo Y Y.2008. MicroRNA-21 targets tumor suppressor genes ininvasion and metastasis. Cell Research, 18, 350-359. |