Journal of Integrative Agriculture ›› 2012, Vol. 12 ›› Issue (1): 109-115.DOI: 10.1016/S1671-2927(00)8514

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Tissue Deposition and Residue Depletion in Broiler Exposed to Melamine-Contaminated Diets

 DING Xue-mei, BAI Shi-ping, ZHANG Ke-ying, WANG Liang, WU Cai-mei, CHEN Dai-wen, JIA Gang , BAI Jie   

  1. 1.Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Yaan 625014, P.R.China
  • 收稿日期:2010-11-04 出版日期:2012-01-01 发布日期:2012-01-13
  • 通讯作者: Correspondence ZHANG Ke-ying, Tel: +86-835-2885630, E-mail: zkeying@yahoo.com
  • 作者简介:DING Xue-mei, Mobile: 13981603429, E-mail: dingxuemei0306@163.com
  • 基金资助:

    This study was supported by the Special Fund for Establishment of Maximum Residue Limit of MEL in feed (Ministry of Agriculture, China).

Tissue Deposition and Residue Depletion in Broiler Exposed to Melamine-Contaminated Diets

 DING Xue-mei, BAI Shi-ping, ZHANG Ke-ying, WANG Liang, WU Cai-mei, CHEN Dai-wen, JIA Gang , BAI Jie   

  1. 1.Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University, Yaan 625014, P.R.China
  • Received:2010-11-04 Online:2012-01-01 Published:2012-01-13
  • Contact: Correspondence ZHANG Ke-ying, Tel: +86-835-2885630, E-mail: zkeying@yahoo.com
  • About author:DING Xue-mei, Mobile: 13981603429, E-mail: dingxuemei0306@163.com
  • Supported by:

    This study was supported by the Special Fund for Establishment of Maximum Residue Limit of MEL in feed (Ministry of Agriculture, China).

摘要: To investigate the tissue deposition and elimination of melamine (MEL) in broilers, a total of 1 920 commercial 1-d-old male Cobb broilers were randomly allotted to 6 treatments with diets contaminated by MEL at 0, 2, 10, 30, 50, 100 mg kg-1 of diet for 42 d, and followed MEL withdrawal from diet at 50 or 100 mg kg-1 of diet for 96 h. The MEL was found in residue of plasma, liver, kidney, breast, and leg muscle with the highest level in kidney and in dose response manner (except in kidney), but no time response (except in plasma). The MEL residue in organ tissue was below the safe level of 50 μg mL-1 in blood or 50 μg kg-1 in tissues proposed by the US FSIS when MEL in diet was lower (2 mg kg-1). The MEL in tissues was eliminated by withdrawal MEL from diets. The elimination half-life of MEL was from 3.2 to 6.6 h, and the clearance time, when MEL residue concentration under limit detection, was from 18.0 to 31.4 h.

关键词: melamine, broiler, deposition, elimination

Abstract: To investigate the tissue deposition and elimination of melamine (MEL) in broilers, a total of 1 920 commercial 1-d-old male Cobb broilers were randomly allotted to 6 treatments with diets contaminated by MEL at 0, 2, 10, 30, 50, 100 mg kg-1 of diet for 42 d, and followed MEL withdrawal from diet at 50 or 100 mg kg-1 of diet for 96 h. The MEL was found in residue of plasma, liver, kidney, breast, and leg muscle with the highest level in kidney and in dose response manner (except in kidney), but no time response (except in plasma). The MEL residue in organ tissue was below the safe level of 50 μg mL-1 in blood or 50 μg kg-1 in tissues proposed by the US FSIS when MEL in diet was lower (2 mg kg-1). The MEL in tissues was eliminated by withdrawal MEL from diets. The elimination half-life of MEL was from 3.2 to 6.6 h, and the clearance time, when MEL residue concentration under limit detection, was from 18.0 to 31.4 h.

Key words: melamine, broiler, deposition, elimination