Antioxidant Effects of Oats Avenanthramides on Human Serum

doi:10.1016/S1671-2927(11)60122-3

摘要/Abstract

摘要： The antioxidant ability of capsules containing oats avenanthramides on human body was evaluated in present study.Healthy people were randomized to supplementation with oats-derived avenanthramides capsules or placebo for 1 mon.Plasma lipid peroxides and antioxidant status were measured. For 8 capsules (containing 3.12 mg avenanthramides)groups, the levels of serum superoxide dismutase (SOD) and reduced glutathione hormone (GSH) were significantlyincreased by 8.4 and 17.9%, respectively (P<0.05), and malondialdehyde (MDA) level significantly decreased by 28.1%.The total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) levels were lowered by 11.1,28.1, and 15.1%, respectively (P<0.05). The high density blood lipoprotein cholesterol (HDL-C) levels in the same treatwas increased by 13.2%. Based on our research, it can be concluded that oats extract containing avenanthramidespossessed a high antioxidative activity on humans. It indicated that oat avenanthramides could be used to preventhyperlipemic and angiocardiopathy.

关键词:

oats avenanthramides, human serum, antioxidation, SOD, MDA, LDL-C, HDL-C

Abstract: The antioxidant ability of capsules containing oats avenanthramides on human body was evaluated in present study.Healthy people were randomized to supplementation with oats-derived avenanthramides capsules or placebo for 1 mon.Plasma lipid peroxides and antioxidant status were measured. For 8 capsules (containing 3.12 mg avenanthramides)groups, the levels of serum superoxide dismutase (SOD) and reduced glutathione hormone (GSH) were significantlyincreased by 8.4 and 17.9%, respectively (P<0.05), and malondialdehyde (MDA) level significantly decreased by 28.1%.The total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) levels were lowered by 11.1,28.1, and 15.1%, respectively (P<0.05). The high density blood lipoprotein cholesterol (HDL-C) levels in the same treatwas increased by 13.2%. Based on our research, it can be concluded that oats extract containing avenanthramidespossessed a high antioxidative activity on humans. It indicated that oat avenanthramides could be used to preventhyperlipemic and angiocardiopathy.

Key words:

oats avenanthramides, human serum, antioxidation, SOD, MDA, LDL-C, HDL-C

LIU Sen, YANG Nan, HOU Zhao-hua, YAO Yang, Lü Li, ZHOU Xian-rong, REN Gui-xing. Antioxidant Effects of Oats Avenanthramides on Human Serum[J]. Journal of Integrative Agriculture, 2011, 10(8): 1301-1305.

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