Journal of Integrative Agriculture ›› 2013, Vol. 12 ›› Issue (8): 1461-1470.DOI: 10.1016/S2095-3119(13)60375-5

• 论文 • 上一篇    下一篇

Development of Genome-Wide Scan for Selection Signature in Farm Animals

 ZHANG Wen-guang   

  1. 1.College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, P.R.China
    2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P.R.China
    3.Institute of ATCG, Nei Mongol Bio-Information, Hohhot 010020, P.R.China
  • 收稿日期:2012-06-20 出版日期:2013-08-01 发布日期:2013-09-12
  • 通讯作者: Correspondence ZHANG Wen-guang, Tel: +86-471-4309173, E-mail: atcgnmbi@aliyun.com
  • 基金资助:

    The authors thank Wang Wen, Kunming Institute of Zoology, CAS, for valuable suggestions on manuscript preparation, and thank Dr. He Yanghua, China Agricultural University, for providing references. Support for this work was provided by the Inner Mongolia Autonomous Region (2010ZD11), the National Natural Science Foundation of China (30960246, 31260538) and the Key Projects in the National Science & Technology Pillar Program (30960242011BAD28B05).

Development of Genome-Wide Scan for Selection Signature in Farm Animals

 ZHANG Wen-guang   

  1. 1.College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, P.R.China
    2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P.R.China
    3.Institute of ATCG, Nei Mongol Bio-Information, Hohhot 010020, P.R.China
  • Received:2012-06-20 Online:2013-08-01 Published:2013-09-12
  • Contact: Correspondence ZHANG Wen-guang, Tel: +86-471-4309173, E-mail: atcgnmbi@aliyun.com
  • Supported by:

    The authors thank Wang Wen, Kunming Institute of Zoology, CAS, for valuable suggestions on manuscript preparation, and thank Dr. He Yanghua, China Agricultural University, for providing references. Support for this work was provided by the Inner Mongolia Autonomous Region (2010ZD11), the National Natural Science Foundation of China (30960246, 31260538) and the Key Projects in the National Science & Technology Pillar Program (30960242011BAD28B05).

PDF

摘要： Identifying targets of positive selection in farm animals has, until recently, been frustratingly slow, relying on the analysis of individual candidate genes. Genomics, however, has provided the necessary resources to systematically interrogate the entire genome for signatures of selection. This review described important recent results derived from the application of genome-wide scan to the study of genetic changes in farm animals. These included findings of regions of the genome that showed breed differentiation, evidence of selective sweeps within individual genomes and signatures of demographic events. Particular attention is focused on the study of the implications for domestication. To date, sixteen genome-wide scans for recent or ongoing positive selection have been performed in farm animals. A key challenge is to begin synthesizing these newly constructed maps of selection into a coherent narrative of animal breed evolutionary history and derive a deeper mechanistic understanding of how animal populations improve or evolve. The major insights from the surveyed studies are highlighted and directions for future study are suggested.

关键词: selection signature , population genomics , genome-wide , animal breeding

Abstract: Identifying targets of positive selection in farm animals has, until recently, been frustratingly slow, relying on the analysis of individual candidate genes. Genomics, however, has provided the necessary resources to systematically interrogate the entire genome for signatures of selection. This review described important recent results derived from the application of genome-wide scan to the study of genetic changes in farm animals. These included findings of regions of the genome that showed breed differentiation, evidence of selective sweeps within individual genomes and signatures of demographic events. Particular attention is focused on the study of the implications for domestication. To date, sixteen genome-wide scans for recent or ongoing positive selection have been performed in farm animals. A key challenge is to begin synthesizing these newly constructed maps of selection into a coherent narrative of animal breed evolutionary history and derive a deeper mechanistic understanding of how animal populations improve or evolve. The major insights from the surveyed studies are highlighted and directions for future study are suggested.

Key words: selection signature , population genomics , genome-wide , animal breeding