Journal of Integrative Agriculture ›› 2024, Vol. 23 ›› Issue (8): 2507-2524.DOI: 10.1016/j.jia.2023.11.038

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脱氧雪腐镰刀菌烯醇对肠道屏障功能的损伤及微生物的解毒机制

  

  • 收稿日期:2023-04-11 接受日期:2023-11-09 出版日期:2024-08-20 发布日期:2024-07-29

Damage on intestinal barrier function and microbial detoxification of deoxynivalenol: A review

Jia Chen*, Xinran Zhang*, Ziqi He, Dongwei Xiong, Miao Long#   

  1. Key Laboratory of Livestock Infectious Diseases, Ministry of Education/College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
  • Received:2023-04-11 Accepted:2023-11-09 Online:2024-08-20 Published:2024-07-29
  • About author:Jia Chen, E-mail: 2020200157@stu.syau.edu.cn; Xinran Zhang, E-mail: 2023220649@stu.syau.edu.cn; #Correspondence Miao Long, E-mail: longmiao@syau.edu.cn * These authors contributed equally to this study.
  • Supported by:
    This work was funded by the National Natural Science Foundation of China (32273074, 31972746, 31872538 and 31772809); the Basic Scientific Research Project of Liaoning Provincial Department of Education, China (LJKZ0632).

摘要:

脱氧雪腐镰刀菌烯醇(DON)是一种由多种镰刀菌产生的真菌毒素,广泛存在于食品和饲料中。低浓度时,它会导致动物和人类的代谢紊乱;高浓度时,会导致身体的病理变化。由于DON对人类/动物健康和动物生产力的影响,因此引起了全世界的广泛关注。DON会对肠道造成严重损伤,包括肠道屏障受损、粘膜损伤、免疫功能减弱和肠道微生物群组成改变。这些影响均加剧了牲畜和家禽的肠道感染和炎症,对机体的健康造成不利影响。此外,研究DON解毒的生物学方法是未来研究的重要途径,这包括使用吸附、酶降解和其他生物方法来减少DON的影响,这些方法为预防和治疗DON诱导的疾病提供了新的策略。DON未来的研究将更加侧重于识别DON的有效解毒微生物或酶,以降低食品和饲料中DON的水平,从而降低其对动物和人类健康的风险。

Abstract:

Deoxynivalenol (DON) is a mycotoxin that is produced by various species of Fusarium and is ubiquitous in food and feed.  At low concentrations, it can cause metabolic disorders in animals and humans and, at high concentrations, it can lead to pathological changes in the body.  The impact of DON on human/animal health and animal productivity has thus attracted a great deal of attention around the world.  DON causes severe damage to the intestine, including compromised intestinal barrier, mucosal damage, weakened immune function, and alterations in gut microbiota composition.  These effects exacerbate intestinal infections and inflammation in livestock and poultry, posing adverse effects on overall health.  Furthermore, research into biological methods for DON detoxification is a crucial avenue for future studies.  This includes the utilization of adsorption, enzymatic degradation, and other biological approaches to mitigate DON’s impact, offering new strategies for prevention and treatment of DON-induced diseases.  Future research will focus on identifying highly efficient detoxifying microorganisms or enzymes to reduce DON levels in food and feed, thereby mitigating its risks to both animals and human health.

Key words: deoxynivalenol (DON) , intestinal barrier function ,  mucus barrier , immune function ,  flora composition ,  biological detoxification