JIA-2020-0788 蘑菇多糖在慢性疾病治疗中的作用

doi:10.1016/S2095-3119(21)63871-6

摘要/Abstract

摘要：

慢性疾病是造成死亡和残疾的主要原因，引起了人们的广泛关注。蘑菇多糖具有多种多样的生物活性，在探索抗慢性疾病的新型无副作用药物方面备受关注。本文综述了在癌症、糖尿病和心血管疾病治疗方面的蘑菇多糖的结构特征、生物学性能及其分子机制。蘑菇多糖抗慢性疾病的潜力在很大程度上取决于其结构特征，包括单糖组成、分子量、糖苷键的类型和构型、支化度、取代基类型和链构象。关于蘑菇多糖的作用机制，有三种疾病共有的途径，也有特定于某种疾病的途径。某些信号通路的调节和肠道菌群的调节是三种慢性疾病共有的途径。此外，转录因子、受体、酶、激素等功能蛋白在蘑菇多糖抗慢性病分子机制中的作用在本文中做了阐述。本文总结了蘑菇多糖治疗慢性疾病的研究现状，并展望了蘑菇多糖治疗慢性疾病的研究前景，有望促进这方面的研究。

Abstract: Chronic diseases have drawn much attention as the primary cause of death and disability. In exploring novel side-effect-free agents against chronic diseases, significant efforts have been devoted to mushroom polysaccharides due to their diverse biological activities. This work reviewed the structural features, biological performances and molecular mechanisms of mushroom polysaccharides in managing cancers, diabetes mellitus and cardiovascular diseases. The potentials of mushroom polysaccharides against chronic diseases highly depend on their structural features, including monosaccharide composition, molecular weight, the type and configuration of glycosidic bonds, degree of branching, the type of substituent pattern and chain conformation. Regarding their working mechanisms, shared and disease-specific pathways were found. The three chronic diseases shared the regulation of specific signalling pathways and the adjustment of gut microbiota. In addition, the roles of transcription factors, receptors, enzymes, hormones and other functional proteins involved in the molecular mechanisms of mushroom polysaccharides against chronic diseases are first elaborated herein. The present review describes the state of the art of mushroom polysaccharides in treating chronic diseases and addresses the perspectives, and will further promote research on this topic.

Key words: mushroom polysaccharide , chronic diseases , structural feature , biological performance , molecular mechanism

. JIA-2020-0788 蘑菇多糖在慢性疾病治疗中的作用[J]. Journal of Integrative Agriculture, 2022, 21(7): 1839-1866.

ZHANG Shan, LEI Lin, ZHOU Yun, YE Fa-yin, ZHAO Guo-hua. Roles of mushroom polysaccharides in chronic disease management[J]. Journal of Integrative Agriculture, 2022, 21(7): 1839-1866.

参考文献

Alfaddagh A, Martin S S, Leucker T M, Michos E D, Blaha M J, Lowenstein C J, Jones S R, Toth P P. 2020. Inflammation and cardiovascular disease: From mechanisms to therapeutics. American Journal of Preventive Cardiology, 4, 100130.
Ali K M, Wonnerth A, Huber K, Wojta J. 2012. Cardiovascular disease risk reduction by raising HDL cholesterol-current therapies and future opportunities. British Journal of Pharmacology, 167, 1177–1194.
Almutary H, Tayyib N. 2020. Factors associated with exercise self-efficacy among people with chronic diseases. Applied Nursing Research, 54, 151275.
Amirullah N A, Abidin N Z, Abdullah N. 2018. The potential applications of mushrooms against some facets of atherosclerosis: A review. Food Research International, 105, 517–536.
Awadasseid A, Hou J, Gamallat Y, Shang X Q, Eugene K D, Hago M A, Bamba D, Meyiah A, Gift C, Xin Y. 2017. Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of Coriolus versicolor. PLoS ONE, 12, e0171270.
Bae I Y, Kim H W, Yoo H J, Kim E S, Lee S, Park D Y, Lee H G. 2013. Correlation of branching structure of mushroom β-glucan with its physiological activities. Food Research International, 51, 195–200.
Bie N, Han L, Wang Y, Wang X, Wang C. 2020. A polysaccharide from Grifola frondosa fruit body induces HT-29 cells apoptosis by PI3K/AKT-MAPKs and NF-κB-pathway. International Journal of Biological Macromolecules, 147, 79–88.
Biscaia S M P, Carbonero E R, Bellan D L, Borges B S, Costa C R, Rossi G R, Gonçalves J P, Melo C M, Lívero F A R, Ruthes A C, Zotz R, Silva E V, Oliveira C C, Acco A, Nader H B, Chammas R, Iacomini M, Franco C R C, Trindade E S. 2017. Safe therapeutics of murine melanoma model using a novel antineoplasic, the partially methylated mannogalactan from Pleurotus eryngii. Carbohydrate Polymers, 178, 95–104.
Cai W D, Ding Z C, Wang Y Y, Yang Y, Zhang H N, Yan J K. 2020. Hypoglycemic benefit and potential mechanism of a polysaccharide from Hericium erinaceus in streptozotoxin-induced diabetic rats. Process Biochemistry, 88, 180–188.
Cao H, Ma S, Guo H, Cui X, Wang S, Zhong X, Wu Y, Zheng W, Wang H, Yu J, Ma L, Chunchao H. 2019. Comparative study on the monosaccharide compositions, antioxidant and hypoglycemic activities in vitro of intracellular and extracellular polysaccharides of liquid fermented Coprinus comatus. International Journal of Biological Macromolecules, 139, 543–549.
Cao X, Xia Y, Liu D, He Y, Mu T, Huo Y, Liu J. 2020. Inhibitory effects of Lentinus edodes mycelia polysaccharide on α-glucosidase, glycation activity and high glucose-induced cell damage. Carbohydrate Polymers, 246, 116659.
Cao X Y, Liu D, Bi R C, He Y L, He Y, Liu J L. 2019. The protective effects of a novel polysaccharide from Lentinus edodes mycelia on islet β (INS-1) cells damaged by glucose and its transportation mechanism with human serum albumin. International Journal of Biological Macromolecules, 134, 344–353.
Castro-Alves V C, Nascimento J R O D. 2018. α- and β-D-Glucans from the edible mushroom Pleurotus albidus differentially regulate lipid-induced inflammation and foam cell formation in human macrophage-like THP-1 cells. International Journal of Biological Macromolecules, 111, 1222–1228.
Chen J, Mao D, Yong Y, Li J, Wei H, Lu L. 2012. Hepatoprotective and hypolipidemic effects of water-soluble polysaccharidic extract of Pleurotus eryngii. Food Chemistry, 130, 687–694.
Chen J, Yong Y, Xia X, Wang Z, Liang Y, Zhang S, Lu L. 2014. The excreted polysaccharide of Pleurotus eryngii inhibits the foam-cell formation via down-regulation of CD36. Carbohydrate Polymers, 112, 16–23.
Chen J, Yong Y, Xing M, Gu Y, Zhang Z, Zhang S, Lu L. 2013. Characterization of polysaccharides with marked inhibitory effect on lipid accumulation in Pleurotus eryngii. Carbohydrate Polymers, 97, 604–613.
Chen J Z, Seviour R. 2007. Medicinal importance of fungal β-(1→3),(1→6)-glucans. Mycological Research, 111, 635–652.
Chen L, Zhang Y, Sha O, Xu W, Wang S. 2016. Hypolipidaemic and hypoglycaemic activities of polysaccharide from Pleurotus eryngii in Kunming mice. International Journal of Biological Macromolecules, 93, 1206–1209.
Chen M, Liao Z, Lu B, Wang M, Lin L, Zhang S, Li Y, Liu D, Liao Q, Xie Z. 2018. Huang-Lian-Jie-Du-Decoction ameliorates hyperglycemia and insulin resistant in association with gut microbiota modulation. Frontiers in Microbiology, 9, 2380.
Chen M, Xiao D, Liu W, Song Y, Zou B, Li L, Li P, Cai Y, Liu D, Liao Q, Xie Z. 2020. Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rats. International Journal of Biological Macromolecules, 155, 890–902.
Chen N, Zhang H, Zong X, Li S, Wang J, Wang Y, Jin M. 2020. Polysaccharides from Auricularia auricula: Preparation, structural features and biological activities. Carbohydrate Polymers, 247, 116750.
Chen X, Xu X, Zhang L, Zeng F. 2009. Chain conformation and anti-tumor activities of phosphorylated (1→3)-β-D-glucan from Poria cocos. Carbohydrate Polymers, 78, 581–587.
Chen Y, Liu D, Wang D, Lai S, Zhong R, Liu Y, Yang C, Liu B, Sarker M R, Zhao C. 2019. Hypoglycemic activity and gut microbiota regulation of a novel polysaccharide from Grifola frondosa in type 2 diabetic mice. Food and Chemical Toxicology, 126, 295–302.
Chen Y, Liu Y, Sarker M M R, Yan X, Yang C, Zhao L, Lv X, Liu B, Zhao C. 2018. Structural characterization and antidiabetic potential of a novel heteropolysaccharide from Grifola frondosa via IRS1/PI3K-JNK signaling pathways. Carbohydrate Polymers, 198, 452–461.
Chen Y, Xie M Y, Nie S P, Li C, Wang Y. 2008. Purification, composition analysis and antioxidant activity of a polysaccharide from the fruiting bodies of Ganoderma atrum. Food Chemistry, 107, 231–241.
Cheng J J, Chang C C, Chao C H, Lu M K. 2012. Characterization of fungal sulfated polysaccharides and their synergistic anticancer effects with doxorubicin. Carbohydrate Polymers, 90, 134–139.
Chistiakov D A, Melnichenko A A, Myasoedova V A, Grechko A V, Orekhov A N. 2017. Mechanisms of foam cell formation in atherosclerosis. Journal of Molecular Medicine, 95, 1153–1165.
Chou Y J, Kan W C, Chang C M, Peng Y J, Wang H Y, Yu W C, Cheng Y H, Jhang Y R, Liu H W, Chuu J J. 2016. Renal protective effects of low molecular weight of Inonotus obliquus polysaccharide (LIOP) on HFD/STZ-induced nephropathy in mice. International Journal of Molecular Sciences, 17, 1535.
Deedwania P C, Pedersen T R, Demicco D A, Breazna A, Betteridge D J, Hitman G A, Durrington P, Neil A. 2016. Differing predictive relationships between baseline LDL-C, systolic blood pressure, and cardiovascular outcomes. International Journal of Cardiology, 222, 548–556.
Diao B Z, Jin W R, Yu X J. 2014. Protective effect of polysaccharides from Inonotus obliquus on streptozotocin-induced diabetic symptoms and their potential mechanisms in rats. Evidence-Based Complementary and Alternative Medicine, 2014, 841496.
Ding J, Jia W, Cui Y, Jin J, Zhang Y, Xu L, Liu Y. 2020. Anti-angiogenic effect of a chemically sulfated polysaccharide from Phellinus ribis by inhibiting VEGF/VEGFR pathway. International Journal of Biological Macromolecules, 154, 72–81.
Dong Y, Qi Y, Liu M, Song X, Zhang C, Jiao X, Wang W, Zhang J, Jia L. 2018. Antioxidant, anti-hyperlipidemia and hepatic protection of enzyme-assisted Morehella esculenta polysaccharide. International Journal of Biological Macromolecules, 120, 1490–1499.
Dong Y, Zhang J, Gao Z, Zhao H, Sun G, Wang X, Jia L. 2019. Characterization and anti-hyperlipidemia effects of enzymatic residue polysaccharides from Pleurotus ostreatus. International Journal of Biological Macromolecules, 129, 316–325.
Dongre A, Weinberg R A. 2018. New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nature Reviews Molecular Cell Biology, 20, 69–84.
Du B, Zhu F, Xu B. 2018. An insight into the anti-inflammatory properties of edible and medicinal mushrooms. Journal of Functional Foods, 47, 334–342.
Engelking L R. 2015. Gluconeogenesis. In: Engelking L R, ed., Textbook of Veterinary Physiological Chemistry. Academic Press, Boston. pp. 225–230.
El Enshasy H A, Hatti-Kaul R. 2013. Mushroom immunomodulators: Unique molecules with unlimited applications. Trends in Biotechnology, 31, 668–677.
Ernst N D, Cleeman J I. 2002. National cholesterol education program keeps a priority on lifestyle modification to decrease cardiovascular disease risk. Current Opinion in Lipidology, 13, 69–73.
Fan L, Ding S, Ai L, Deng K. 2012. Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus. Carbohydrate Polymers, 90, 870–874.
Feng H, Zhang S J, Wan J M F, Gui L F, Ruan M C, Li N, Zhang H Y, Liu Z G, Wang H L. 2018. Polysaccharides extracted from Phellinus linteus ameliorate high-fat high-fructose diet induced insulin resistance in mice. Carbohydrate Polymers, 200, 144–153.
Feng Y Q, Zhang J X, Wen C T, Dzah C S, Juliet I C, Duan Y Q, Zhang H H. 2020. Recent advances in Agaricus bisporus polysaccharides: Extraction, purification, physicochemical characterization and bioactivities. Process Biochemistry, 94, 39–50.
Fu Y, Shi L, Ding K. 2019. Structure elucidation and anti-tumor activity in vivo of a polysaccharide from spores of Ganoderma lucidum (Fr.) Karst. International Journal of Biological Macromolecules, 141, 693–699.
Gao Q, Xu L, Cai J. 2021. New drug targets for hypertension: A literature review. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1867, 166037.
Gao Z, Kong D, Cai W, Zhang J, Jia L. 2021. Characterization and anti-diabetic nephropathic ability of mycelium polysaccharides from Coprinus comatus. Carbohydrate Polymers, 251, 117081.
Gasa R, Gomis R, Novials A, Servitja J M. 2016. Molecular aspects of glucose regulation of pancreatic β cells. In: Mauricio D, ed., Molecular Nutrition and Diabetes. Academic Press, San Diego. pp. 155–168.
Gong P, Wang S, Liu M, Chen F, Yang W, Chang X, Liu N, Zhao Y, Wang J, Chen X. 2020. Extraction methods, chemical characterizations and biological activities of mushroom polysaccharides: A mini-review. Carbohydrate Research, 494, 108037.
Gong Y, Zhang J, Gao F, Zhou J, Xiang Z, Zhou C, Wan L, Chen J. 2017. Structure features and in vitro hypoglycemic activities of polysaccharides from different species of Maidong. Carbohydrate Polymers, 173, 215–222.
Gunasekaran S, Govindan S, Ramani P. 2021. Sulfated modification, characterization and bioactivities of an acidic polysaccharide fraction from an edible mushroom Pleurotus eous (Berk.) Sacc. Heliyon, 7, e05964.
Guney M A, Lorberbaum D S, Sussel L. 2020. Pancreatic β cell regeneration: To β or not to β. Current Opinion in Physiology, 14, 13–20.
Guo L. 2020. Under the background of healthy China: Regulating the analysis of hybrid machine learning in sports activities to control chronic diseases. Measurement, 164, 107847.
Guo W L, Deng J C, Pan Y Y, Xu J X, Hong J L, Shi F F, Liu G L, Qian M, Bai W D, Zhang W, Liu B, Zhang Y Y, Luo P J, Ni L, Rao P F, Lv X C. 2020. Hypoglycemic and hypolipidemic activities of Grifola frondosa polysaccharides and their relationships with the modulation of intestinal microflora in diabetic mice induced by high-fat diet and streptozotocin. International Journal of Biological Macromolecules, 153, 1231–1240.
Han S, Ma C, Hu M, Wang Y, Ma F, Tao N, Qin Z. 2017. A polysaccharide from Dictyophora indusiata inhibits the immunosuppressive function of cancer-associated fibroblasts. Cell Biochemistry and Function, 35, 414–419.
Hao Y, Sun H, Zhang X, Wu L, Zhu Z. 2020. A novel acid polysaccharide from fermented broth of Pleurotus citrinopileatus: Hypoglycemic activity in vitro and chemical structure. Journal of Molecular Structure, 1220, 128717.
Hatanaka K, Song S C, Maruyama A, Kobayashi A, Kuzuhara H, Akaike T. 1992. A new synthetic hypoglycaemic polysaccharide. Biochemical and Biophysical Research Communications, 188, 16–19.
Hsu W K, Hsu T H, Lin F Y, Cheng Y K, Yang J P W. 2013. Separation, purification, and α-glucosidase inhibition of polysaccharides from Coriolus versicolor LH1 mycelia. Carbohydrate Polymers, 92, 297–306.
Hu S, Wang J, Li F, Hou P, Yin J, Yang Z, Yang X, Li T, Xia B, Zhou G, Liu M, Song W, Guo S. 2019. Structural characterisation and cholesterol efflux improving capacity of the novel polysaccharides from Cordyceps militaris. International Journal of Biological Macromolecules, 131, 264–272.
Hu W, Wang J, Guo W, Liu Y, Guo Z, Miao Y, Wang D. 2020. Studies on characteristics and anti-diabetic and -nephritic effects of polysaccharides isolated from Paecilomyces hepiali fermentation mycelium in db/db mice. Carbohydrate Polymers, 232, 115766.
Hui X, Wu G, Han D, Stipkovits L, Wu X, Tang S, Brennan M A, Brennan C S. 2020. The effects of bioactive compounds from blueberry and blackcurrant powders on the inhibitory activities of oat bran pastes against α-amylase and α-glucosidase linked to type 2 diabetes. Food Research International, 138, 109756.
Ighodaro O M. 2018. Molecular pathways associated with oxidative stress in diabetes mellitus. Biomedicine and Pharmacotherapy, 108, 656–662.
Jantan I, Haque M A, Arshad L, Harikrishnan H, Septama A W, Mohamed-Hussein Z A. 2021. Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways. The Journal of Nutritional Biochemistry, 93, 108634.
Jeong S C, Jeong Y T, Yang B K, Islam R, Koyyalamudi S R, Pang G, Cho K Y, Song C H. 2010. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutrition Research, 30, 49–56.
Khan N, Adhami V M, Mukhtar H. 2008. Apoptosis by dietary agents for prevention and treatment of cancer. Biochemical Pharmacology, 76, 1333–1339.
Kiho T, Sobue S, Ukai S. 1994. Structural features and hypoglycemic activities of two polysaccharides from a hot-water extract of Agrocybe cylindracea. Carbohydrate Research, 251, 81–87.
Kong F, Li F E, He Z, Jiang Y, Hao R, Sun X, Tong H. 2014. Anti-tumor and macrophage activation induced by alkali-extracted polysaccharide from Pleurotus ostreatus. International Journal of Biological Macromolecules, 69, 561–566.
Kou L, Du M, Liu P, Yang P, Shang M. 2018. Studies on the anti-diabetic nephropathy effects of polysaccharide purified from Grifola frondosa fruiting body via modulation on oxidative stress. Journal of the American College of Cardiology, 72, C188.
Kowalczewska M, Piotrowski J, Jędrzejewski T, Kozak W. 2016. Polysaccharide peptides from Coriolus versicolor exert differential immunomodulatory effects on blood lymphocytes and breast cancer cell line MCF-7 in vitro. Immunology Letters, 174, 37–44.
Lee J S, Hong E K. 2010. Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells. Cancer Letters, 297, 144–154.
Lee M H, Chao C H, Hsu Y C, Lu M K. 2020. Production, characterization, and functions of sulfated polysaccharides from zinc sulfate enriched cultivation of Antrodia cinnamomea. International Journal of Biological Macromolecules, 159, 1013–1021.
Li C, Mao X, Xu B. 2013. Pulsed electric field extraction enhanced anti-coagulant effect of fungal polysaccharide from Jew’s Ear (Auricularia auricula). Phytochemical Analysis, 24, 36–40.
Li H, Xia N. 2020. The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness. Redox Biology, 37, 101585.
Li H, Zhang M, Ma G. 2010. Hypolipidemic effect of the polysaccharide from Pholiota nameko. Nutrition, 26, 556–562.
Li L, Guo W L, Zhang W, Xu J X, Qian M, Bai W D, Zhang Y Y, Rao P F, Ni L, Lv X C. 2019. Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats. Food & Function, 10, 2560–2572.
Li L F, Liu H B, Zhang Q W, Li Z P, Wong T L, Fung H Y, Zhang J X, Bai S P, Lu A P, Han Q B. 2018. Comprehensive comparison of polysaccharides from Ganoderma lucidum and G. sinense: Chemical, antitumor, immunomodulating and gut-microbiota modulatory properties. Scientific Reports, 8, 6172.
Li N, Wang C, Georgiev M I, Bajpai V K, Tundis R, Simal-Gandara J, Lu X, Xiao J, Tang X, Qiao X. 2021. Advances in dietary polysaccharides as anticancer agents: Structure–activity relationship. Trends in Food Science & Technology, 111, 360–377.
Li S C, Yang X M, Ma H L, Yan J K, Guo D Z. 2015. Purification, characterization and antitumor activity of polysaccharides extracted from Phellinus igniarius mycelia. Carbohydrate Polymers, 133, 24–30.
Li W, Zhao J, Yao Q, Li W, Zhi W, Zang L, Liu F, Niu X. 2019. Polysaccharides from Poria cocos (PCP) inhibits ox-LDL-induced vascular smooth muscle cells proliferation and migration by suppressing TLR4/NF-κB p65 signaling pathway. Journal of Functional Foods, 60, 103391.
Li X, Xue Y, Pang L, Len B, Lin Z, Huang J, Shangguan Z, Pan Y. 2019. Agaricus bisporus-derived β-glucan prevents obesity through PPAR γ downregulation and autophagy induction in zebrafish fed by chicken egg yolk. International Journal of Biological Macromolecules, 125, 820–828.
Li Y, Sheng Y, Lu X, Guo X, Xu G, Han X, An L, Du P. 2020. Isolation and purification of acidic polysaccharides from Agaricus blazei Murill and evaluation of their lipid-lowering mechanism. International Journal of Biological Macromolecules, 157, 276–287.
Li Y, Yuan Y, Lei L, Li F, Zhang Y, Chen J, Zhao G, Wu S, Yin R, Ming J. 2017. Carboxymethylation of polysaccharide from Morchella angusticepes Peck enhances its cholesterol-lowering activity in rats. Carbohydrate Polymers, 172, 85–92.
Liang Z E, Yi Y J, Guo Y T, Wang R C, Hu Q L, Xiong X Y. 2015. Inhibition of migration and induction of apoptosis in LoVo human colon cancer cells by polysaccharides from Ganoderma lucidum. Molecular Medicine Reports, 12, 7629–7636.
Lim H Y, O’Malley C, Donnan G, Nandurkar H, Ho P. 2019. A review of global coagulation assays - Is there a role in thrombosis risk prediction? Thrombosis Research, 179, 45–55.
Liu F, Zhu Z Y, Sun X, Gao H, Zhang Y M. 2017. The preparation of three selenium-containing Cordyceps militaris polysaccharides: Characterization and anti-tumor activities. International Journal of Biological Macromolecules, 99, 196–204.
Liu M M, Zeng P, Li X T, Shi L G. 2016. Antitumor and immunomodulation activities of polysaccharide from Phellinus baumii. International Journal of Biological Macromolecules, 91, 1199–1205.
Liu W, Xu J, Jing P, Yao W, Gao X, Yu L. 2010. Preparation of a hydroxypropyl Ganoderma lucidum polysaccharide and its physicochemical properties. Food Chemistry, 122, 965–971.
Liu X, Wang X, Xu X, Zhang X. 2019. Purification, antitumor and anti-inflammation activities of an alkali-soluble and carboxymethyl polysaccharide CMP33 from Poria cocos. International Journal of Biological Macromolecules, 127, 39–47.
Liu X C, Zhu Z Y, Liu Y L, Sun H Q. 2019. Comparisons of the anti-tumor activity of polysaccharides from fermented mycelia and cultivated fruiting bodies of Cordyceps militaris in vitro. International Journal of Biological Macromolecules, 130, 307–314.
Liu X C, Zhu Z Y, Tang Y L, Wang M F, Wang Z, Liu A J, Zhang Y M. 2016. Structural properties of polysaccharides from cultivated fruit bodies and mycelium of Cordyceps militaris. Carbohydrate Polymers, 142, 63–72.
Liu Y, Liu Y, Jiang H, Xu L, Cheng Y, Wang P G, Wang F. 2014. Preparation, antiangiogenic and antitumoral activities of the chemically sulfated glucan from Phellinus ribis. Carbohydrate Polymers, 106, 42–48.
Liu Y, Tang Q, Duan X, Tang T, Ke Y, Zhang L, Li C, Liu A, Su Z, Hu B. 2018. Antioxidant and anticoagulant activities of mycelia polysaccharides from Catathelasma ventricosum after sulfated modification. Industrial Crops and Products, 112, 53–60.
Liu Y, Zhang L, Zhu X, Wang Y, Liu W, Gong W. 2015. Polysaccharide Agaricus blazei Murill stimulates myeloid derived suppressor cell differentiation from M2 to M1 type, which mediates inhibition of tumour immune-evasion via the Toll-like receptor 2 pathway. Immunology, 146, 379–391.
Liu Y F, Zhao Y, Yang Y, Tang Q J, Zhou S, Wu D, Zhang J S. 2013. Structural characteristics and hypoglycemic activity of polysaccharides from Coprinus comatus. Bioactive Carbohydrates and Dietary Fibre, 2, 164–169.
Liu Y T, Liu Y X, Zhang M Y, Li C, Zhang Z Q, Liu A P, Wu Y L, Wu H J, Chen H, Hu X J, Lin B K, Wu W J. 2020. Structural characterization of a polysaccharide from Suillellus luridus and its antidiabetic activity via Nrf2/HO-1 and NF-κB pathways. International Journal of Biological Macromolecules, 162, 935–945.
Liu Y T, Sun J, Rao S Q, Su Y J, Yang Y J. 2013. Antihyperglycemic, antihyperlipidemic and antioxidant activities of polysaccharides from Catathelasma ventricosum in streptozotocin-induced diabetic mice. Food and Chemical Toxicology, 57, 39–45.
Liu Y Y, Wang C R, Li J S, Li T T, Zhang Y, Liang Y X, Mei Y X. 2020. Phellinus linteus polysaccharide extract improves insulin resistance by regulating gut microbiota composition. The Federation of American Societies for Expermental Biology Journal, 34, 1065–1078.
Lu A, Yu M, Shen M, Xu S, Xu Z, Zhang Y, Lin Z, Wang W. 2018. Preparation of the Auricularia auricular polysaccharides simulated hydrolysates and their hypoglycaemic effect. International Journal of Biological Macromolecules, 106, 1139–1145.
Lu W J, Chang N C, Jayakumar T, Liao J C, Lin M J, Wang S H, Chou D S, Thomas P A, Sheu J R. 2014. Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP. Thrombosis Research, 134, 1301–1310.
Luo J, Zhang C, Liu R, Gao L, Ou S, Liu L, Peng X. 2018. Ganoderma lucidum polysaccharide alleviating colorectal cancer by alteration of special gut bacteria and regulation of gene expression of colonic epithelial cells. Journal of Functional Foods, 47, 127–135.
Luo Q, Yan L, Xu P, Xiong C, Yang Z, Hu P, Hu H, Hong R. 2018. Discovery of a polysaccharide from the fruiting bodies of Lepista sordida as potent inhibitors of indoleamine 2, 3-dioxygenase (IDO) in HepG2 cells via blocking of STAT1-mediated JAK-PKC-δ signaling pathways. Carbohydrate Polymers, 197, 540–547.
Lv X C, Guo W L, Li L, Yu X D, Liu B. 2019. Polysaccharide peptides from Ganoderma lucidum ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet-fed rats. Journal of Functional Foods, 57, 48–58.
Ma G, Yang W, Mariga A M, Fang Y, Ma N, Pei F, Hu Q. 2014. Purification, characterization and antitumor activity of polysaccharides from Pleurotus eryngii residue. Carbohydrate Polymers, 114, 297–305.
Maeda Y Y, Watanabe S T, Chihara C, Rokutanda M. 1988. Denaturation and renaturation of a beta-1,6;1,3-glucan, lentinan, associated with expression of T-cell-mediated responses. Cancer Research, 48, 671–675.
Mao G, Li Q, Deng C, Wang Y, Ding Y, Zhang W, Chen Y, Zhao T, Wei F, Yang L, Wu X. 2018. The synergism and attenuation effect of selenium (Se)-enriched Grifola frondosa (Se)-polysaccharide on 5-fluorouracil (5-Fu) in Heps-bearing mice. International Journal of Biological Macromolecules, 107, 2211–2216.
Mao G H, Ren Y, Feng W W, Li Q, Wu H Y, Dun J, Zhao T, Xu C Q, Yang L Q, Wu X Y. 2015. Antitumor and immunomodulatory activity of a water-soluble polysaccharide from Grifola frondosa. Carbohydrate Polymers, 134, 406–412.
Mao G H, Zhang Z H, Fei F, Ding Y Y, Zhang W J, Chen H, Ali S S, Zhao T, Feng W W, Wu X Y, Yang L Q. 2019. Effect of Grifola frondosa polysaccharide on anti-tumor activity in combination with 5-Fu in heps-bearing mice. International Journal of Biological Macromolecules, 121, 930–935.
Maroufi N F, Ashouri N, Mortezania Z, Ashoori Z, Vahedian V, Amirzadeh-Iranaq M T, Fattahi A, Kazemzadeh H, Bizzarri M, Akbarzadeh M, Nejabati H R, Faridvand Y, Rashidi M R, Nouri M. 2020. The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor. Pathology Research and Practice, 216, 153226.
Masuda Y, Akihisa M, Oikawa T, Ito K, Nanba H. 2009. Characterization and antitumor effect of a novel polysaccharide from Grifola frondosa. Journal of Agricultural and Food Chemistry, 57, 10143–10149.
Masuda Y, Ito K, Konishi M, Nanba H. 2010. A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer. Cancer Immunology, Immunotherapy, 59, 1531–1541.
Meneguin A B, Silvestre A L P, Sposito L, de Souza M P C, Sábio R M, Araújo V H S, Cury B S F, Chorilli M. 2021. The role of polysaccharides from natural resources to design oral insulin micro- and nanoparticles intended for the treatment of diabetes mellitus: A review. Carbohydrate Polymers, 256, 117504.
Meng G, Zhu H, Yang S, Wu F, Zheng H, Chen E, Xu J. 2011. Attenuating effects of Ganoderma lucidum polysaccharides on myocardial collagen cross-linking relates to advanced glycation end product and antioxidant enzymes in high-fat-diet and streptozotocin-induced diabetic rats. Carbohydrate Polymers, 84, 180–185.
Meng M, Cheng D, Han L, Chen Y, Wang C. 2017. Isolation, purification, structural analysis and immunostimulatory activity of water-soluble polysaccharides from Grifola frondosa fruiting body. Carbohydrate Polymers, 157, 1134–1143.
Meng M, Guo M, Wang P, Han R, Zhou J, Wang C. 2019. Chemopreventive effect of the polysaccharides from Grifola frondosa in colitis-associated colorectal cancer by modulating the Wnt/β-catenin/GSK-3β signaling pathway in C57BL/6 mice. Journal of Functional Foods, 63, 103578.
Meng X, Liang H, Luo L. 2016. Antitumor polysaccharides from mushrooms: A review on the structural characteristics, antitumor mechanisms and immunomodulating activities. Carbohydrate Research, 424, 30–41.
Meng Y, Lyu F, Xu X, Zhang L. 2020. Recent advances in chain conformation and bioactivities of triple-helix polysaccharides. Biomacromolecules, 21, 1653–1677.
Miao S, Mao X, Pei R, Miao S, Xiang C, Lv Y, Yang X, Sun J, Jia S, Liu Y. 2013. Antitumor activity of polysaccharides from Lepista sordida against laryngocarcinoma in vitro and in vivo. International Journal of Biological Macromolecules, 60, 235–240.
Mizuno M, Morimoto M, Minato K, Tsuchida H. 1998. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Bioscience, Biotechnology, and Biochemistry, 62, 434–437.
Morales D, Rutckeviski R, Villalva M, Abreu H, Soler-Rivas C, Santoyo S, Iacomini M, Smiderle F R. 2020. Isolation and comparison of α- and β-D-glucans from shiitake mushrooms (Lentinula edodes) with different biological activities. Carbohydrate Polymers, 229, 115521.
Niu Y C, Liu J C, Zhao X M, Cao J. 2009. A low molecular weight polysaccharide isolated from Agaricus blazei Murill (LMPAB) exhibits its anti-metastatic effect by down-regulating metalloproteinase-9 and up-regulating nm23-H1. The American Journal of Chinese Medicine, 37, 909–921.
Novak M, Vetvicka V. 2008. β-Glucans, history, and the present: Immunomodulatory aspects and mechanisms of action. Journal of Immunotoxicology, 5, 47–57.
Nuo X, Ren Z, Zhang J, Song X, Gao Z, Jing H, Li S, Wang S, Jia L. 2017. Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis. International Journal of Biological Macromolecules, 95, 204–214.
Olatunji O J, Feng Y, Olatunji O O, Tang J, Wei Y, Ouyang Z, Su Z L. 2016. Polysaccharides purified from Cordyceps cicadae protects PC12 cells against glutamate-induced oxidative damage. Carbohydrate Polymers, 153, 187–195.
Ooi V E C. 2008. Antitumor and immunomodulatory activities of mushroom polysaccharides. In: Cheung P C K ed., Mushrooms as Functional Foods. John Wiley & Sons, Hoboken, New Jersey. pp. 147–198.
Pan D, Wang L, Chen C, Hu B, Zhou P. 2015. Isolation and characterization of a hyperbranched proteoglycan from Ganoderma lucidum for anti-diabetes. Carbohydrate Polymers, 117, 106–114.
Pan Y, Wan X, Zeng F, Zhong R, Guo W, Lv X C, Zhao C, Liu B. 2020. Regulatory effect of Grifola frondosa extract rich in polysaccharides and organic acids on glycolipid metabolism and gut microbiota in rats. International Journal of Biological Macromolecules, 155, 1030–1039.
Pires A D R A, Ruthes A C, Cadena S M S C, Acco A, Gorin P A J, Iacomini M. 2013. Cytotoxic effect of Agaricus bisporus and Lactarius rufus β-D-glucans on HepG2 cells. International Journal of Biological Macromolecules, 58, 95–103.
Pires A D R A, Ruthes A C, Cadena S M S C, Iacomini M. 2017. Cytotoxic effect of a mannogalactoglucan extracted from Agaricus bisporus on HepG2 cells. Carbohydrate Polymers, 170, 33–42.
Qi W, Zhou X, Wang J, Zhang K, Zhou Y, Chen S, Nie S, Xie M. 2020. Cordyceps sinensis polysaccharide inhibits colon cancer cells growth by inducing apoptosis and autophagy flux blockage via mTOR signaling. Carbohydrate Polymers, 237, 116113.
Rajoka M S R, Mehwish H M, Xiong Y, Song X, Hussain N, Zhu Q, He Z. 2021. Gut microbiota targeted nanomedicine for cancer therapy: Challenges and future considerations. Trends in Food Science & Technology, 107, 240–251.
Ren D, Wang N, Guo J, Yuan L, Yang X. 2016. Chemical characterization of Pleurotus eryngii polysaccharide and its tumor-inhibitory effects against human hepatoblastoma HepG-2 cells. Carbohydrate Polymers, 138, 123–133.
Ren Z, Li J, Xu N, Zhang J, Song X, Wang X, Gao Z, Jing H, Li S, Zhang C, Liu M, Zhao H, Jia L. 2017. Anti-hyperlipidemic and antioxidant effects of alkali-extractable mycelia polysaccharides by Pleurotus eryngii var. tuoliensis. Carbohydrate Polymers, 175, 282–292.
Román Y, Iacomini M, Sassaki G L, Cipriani T R. 2016. Optimization of chemical sulfation, structural characterization and anticoagulant activity of Agaricus bisporus fucogalactan. Carbohydrate Polymers, 146, 345–352.
Saito K, Nishijima M, Miyazaki T. 1992. Structure of a heteroglycan isolated from the fungus Omphalia lapidescens. Carbohydrate Research, 224, 209–217.
Sargowo D, Aissy C, Kalsum U, Nugroho F, Kamila P, Irawan D, Sitio M, Adrian L, Pratama A, Arifin Y, Fadlan R, Sari D, Purwanto E, Rahmah F, Sukatman M, Rahmawati N, Fahmiy R. 2019. The role of polysaccharide peptide of Ganoderma lucidum as a potent protective vascular endothelial cell, anti inflammation, and antioxidant in STEMI and NSTEMI patients. AIP Conference Proceedings, 2108, 020004.
Sargowo D, Ovianti N, Susilowati E, Ubaidillah N, Nugraha A W, Vitriyaturrida, Proboretno K S, Failasufi M, Ramadhan F, Wulandari H, Waranugraha Y, Putri D H. 2018. The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients. Indian Heart Journal, 70, 608–614.
Schulz C, Massberg S. 2014. Atherosclerosis-multiple pathways to lesional macrophages. Science Translational Medicine, 6, 239ps2.
Sethwala A M, Goh I, Amerena J V. 2021. Combating inflammation in cardiovascular disease. Heart, Lung and Circulation, 30, 197–206.
Su J, Su L, Li D, Shuai O, Zhang Y, Liang H, Jiao C, Xu Z, Lai Y, Xie Y. 2018. Antitumor activity of extract from the sporoderm-breaking spore of Ganoderma lucidum: Restoration on exhausted cytotoxic T cell with gut microbiota remodeling. Frontiers in Immunology, 9, 1765–1765.
Sun S S, Wang K, Ma K, Bao L, Liu H W. 2019. An insoluble polysaccharide from the sclerotium of Poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota. Chinese Journal of Natural Medicines, 17, 3–14.
Tahrani A A, Bailey C J, Del Prato S, Barnett A H. 2011. Management of type 2 diabetes: New and future developments in treatment. The Lancet, 378, 182–197.
Telles C B S, Sabry D A, Almeida-Lima J, Costa M S S P, Melo-Silveira R F, Trindade E S, Sassaki G L, Wisbeck E, Furlan S A, Leite E L, Rocha H A O. 2011. Sulfation of the extracellular polysaccharide produced by the edible mushroom Pleurotus sajor-caju alters its antioxidant, anticoagulant and antiproliferative properties in vitro. Carbohydrate Polymers, 85, 514–521.
Thongnak L, Pongchaidecha A, Lungkaphin A. 2020. Renal lipid metabolism and lipotoxicity in diabetes. The American Journal of the Medical Sciences, 359, 84–99.
Tong A J, Hu R K, Wu L X, Lv X C, Li X, Zhao L N, Liu B. 2020. Ganoderma polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition in high fat diet-fed golden hamsters. Journal of Food Biochemistry, 44, e13109.
Tsai P F, Ma C Y, Wu J S B. 2013. A novel glycoprotein from mushroom Hypsizygus marmoreus (Peck) Bigelow with growth inhibitory effect against human leukaemic U937 cells. Food Chemistry, 141, 1252–1258.
Vasu S, McClenaghan N H, McCluskey J T, Flatt P R. 2014. Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4. Biochimica et Biophysica Acta-General Subjects, 1840, 136–145.
Volman J J, Helsper J P F G, Wei S, Baars J J P, Van Griensven L J L D, Sonnenberg A S M, Mensink R P, Plat J. 2010. Effects of mushroom-derived β-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-κB transactivation in Caco-2 reporter cells: Can effects be explained by structure? Molecular Nutrition & Food Research, 54, 268–276.
Wang C L, Meng M, Liu S B, Wang L R, Hou L H, Cao X H. 2013. A chemically sulfated polysaccharide from Grifola frondosa induces HepG2 cell apoptosis by notch1-NF-κB pathway. Carbohydrate Polymers, 95, 282–287.
Wang D, Sun S Q, Wu W Z, Yang S L, Tan J M. 2014. Characterization of a water-soluble polysaccharide from Boletus edulis and its antitumor and immunomodulatory activities on renal cancer in mice. Carbohydrate Polymers, 105, 127–134.
Wang J, Hu W, Li L, Huang X, Liu Y, Wang D, Teng L. 2017a. Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes. PLoS ONE, 12, e0180476.
Wang J, Li W, Huang X, Liu Y, Qiang L, Zheng Z, Wang K. 2016. A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice. Oncotarget, 8, 610–623.
Wang J, Wang C, Li S, Li W, Yuan G, Pan Y, Chen H. 2017b. Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway. Biomedicine & Pharmacotherapy, 95, 1669–1677.
Wang L, Xu N, Zhang J, Zhao H, Lin L, Jia S, Jia L. 2015. Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12. Carbohydrate Polymers, 131, 355–362.
Wang L, Zhang P Z, Shen J W, Qian Y Y, Liu M, Ruan Y, Wang X G, Zhang S N, Ma B J. 2019. Physicochemical properties and bioactivities of original and Se-enriched polysaccharides with different molecular weights extracted from Pleurotus ostreatus. International Journal of Biological Macromolecules, 141, 150–160.
Wang Y, Shou J W, Li X Y, Zhao Z X, Fu J, He C Y, Feng R, Ma C, Wen B Y, Guo F, Yang X Y, Han Y X, Wang L L, Tong Q, You X F, Lin Y, Kong W J, Si S Y, Jiang J D, 2017. Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism. Metabolism, 70, 72–84.
Wasser S. 2002. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Applied Microbiology and Biotechnology, 60, 258–274.
Wickström J E, Jalkanen J M, Venermo M, Hakovirta H H. 2017. Crural index and extensive atherosclerosis of crural vessels are associated with long-term cardiovascular mortality in patients with symptomatic peripheral artery disease. Atherosclerosis, 264, 44–50.
Wu Q, Tan Z, Liu H, Gao L, Wu S, Luo J, Zhang W, Zhao T, Yu J, Xu X. 2010. Chemical characterization of Auricularia auricula polysaccharides and its pharmacological effect on heart antioxidant enzyme activities and left ventricular function in aged mice. International Journal of Biological Macromolecules, 46, 284–288.
Wu S. 2018. Hypolipidaemic and anti-lipidperoxidant activities of Ganoderma lucidum polysaccharide. International Journal of Biological Macromolecules, 118, 2001–2005.
Xiang F, Lin L, Hu M, Qi X. 2016. Therapeutic efficacy of a polysaccharide isolated from Cordyceps sinensis on hypertensive rats. International Journal of Biological Macromolecules, 82, 308–314.
Xiang H, Sun-Waterhouse D, Cui C. 2020. Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice. Food Science and Human Wellness, 10, 87–93.
Xiao C, Wu Q P, Cai W, Tan J B, Yang X B, Zhang J M. 2012. Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice. Archives of Pharmacal Research, 35, 1793–1801.
Xiao C, Wu Q, Zhang J, Xie Y, Cai W, Tan J. 2017. Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice. Journal of Ethnopharmacology, 196, 47–57.
Xiao Y, Chen L, Fan Y, Yan P, Li S, Zhou X. 2019. The effect of boletus polysaccharides on diabetic hepatopathy in rats. Chemico-Biological Interactions, 308, 61–69.
Xu C, Zhong H Y, Zeng J H, Ge J. 2008. The pharmacological effect of polysaccharides from Lentinus edodes on the oxidative status and expression of VCAM-1mRNA of thoracic aorta endothelial cell in high-fat-diet rats. Carbohydrate Polymers, 74, 445–450.
Xu H, Liu L, Ding M, Fan Wen, Chen C, Song H. 2020. Effect of Ganoderma applanatum polysaccharides on MAPK/ERK pathway affecting autophagy in breast cancer MCF-7 cells. International Journal of Biological Macromolecules, 146, 353–362.
Xu J, Lian F, Zhao L, Zhao Y, Chen X, Zhang X, Guo Y, Zhang C, Zhou Q, Xue Z, Pang X, Zhao L, Tong X. 2015. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula. The International Society for Microbial Ecology Journal, 9, 552–562.
Xu N, Gao Z, Zhang J, Jing H, Li S, Ren Z, Wang S, Jia L. 2017a. Hepatoprotection of enzymatic-extractable mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis. Carbohydrate Polymers, 157, 196–206.
Xu N, Ren Z, Zhang J, Song X, Gao Z, Jing H, Li S, Wang S, Jia L. 2017b. Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis. International Journal of Biological Macromolecules, 95, 204–214.
Xu Y, Zhang X, Yan X H, Zhang J L, Wang L Y, Xue H, Jiang G C, Ma X T, Liu X J. 2019. Characterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum. International Journal of Biological Macromolecules, 135, 706–716.
Yan J K, Ding Z C, Gao X, Wang Y Y, Yang Y, Wu D, Zhang H N. 2018. Comparative study of physicochemical properties and bioactivity of Hericium erinaceus polysaccharides at different solvent extractions. Carbohydrate Polymers, 193, 373–382.
Yan J K, Wang W Q, Li L, Wu J Y. 2011. Physiochemical properties and antitumor activities of two α-glucans isolated from hot water and alkaline extracts of Cordyceps (Cs-HK1) fungal mycelia. Carbohydrate Polymers, 85, 753–758.
Yang C, Feng Q, Liao H, Yu X, Liu Y, Wang D. 2019. Anti-diabetic nephropathy activities of polysaccharides obtained from Termitornyces albuminosus via regulation of NF-κB signaling in db/db mice. International Journal of Molecular Sciences, 20, 5205.
Yang J, Dong H, Wang Y, Jiang Y, Zhang W, Lu Y, Chen Y, Chen L. 2020. Cordyceps cicadae polysaccharides ameliorated renal interstitial fibrosis in diabetic nephropathy rats by repressing inflammation and modulating gut microbiota dysbiosis. International Journal of Biological Macromolecules, 163, 442–456.
Yang R, Li Y, Mehmood S, Yan C, Huang Y, Cai J, Ji J, Pan W, Zhang W, Chen Y. 2020. Polysaccharides from Armillariella tabescens mycelia ameliorate renal damage in type 2 diabetic mice. International Journal of Biological Macromolecules, 162, 1682–1691.
Yang S, Yan J, Yang L, Meng Y, Wang N, He C, Fan Y, Zhou Y. 2019. Alkali-soluble polysaccharides from mushroom fruiting bodies improve insulin resistance. International Journal of Biological Macromolecules, 126, 466–474.
Yang Z, Chen C, Zhao J, Xu W, He Y, Yang H, Zhou P. 2018. Hypoglycemic mechanism of a novel proteoglycan, extracted from Ganoderma lucidum, in hepatocytes. European Journal of Pharmacology, 820, 77–85.
Yang Z, Xu J, Fu Q, Fu X, Shu T, Bi Y, Song B. 2013. Antitumor activity of a polysaccharide from Pleurotus eryngii on mice bearing renal cancer. Carbohydrate Polymers, 95, 615–620.
Yin C, Noratto G D, Fan X, Chen Z, Yao F, Shi D, Gao H. 2020. The impact of mushroom polysaccharides on gut microbiota and its beneficial effects to host: A review. Carbohydrate Polymers, 250, 116942.
Yue L, Cui H, Li C, Lin Y, Sun Y, Niu Y, Wen X, Liu J. 2012. A polysaccharide from Agaricus blazei attenuates tumor cell adhesion via inhibiting E-selectin expression. Carbohydrate Polymers, 88, 1326–1333.
Zeng F, Zhao C, Pang J, Lin Z, Huang Y, Liu B. 2013. Chemical properties of a polysaccharide purified from solid-state fermentation of Auricularia auricular and its biological activity as a hypolipidemic agent. Journal of Food Science, 78, H1470–H1475.
Zhang C, Li J, Hu C, Wang J, Zhang J, Ren Z, Song X, Jia L. 2017. Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice. Scientific Reports, 7, 10847.
Zhang C, Zhang L, Liu H, Zhang J, Hu C, Jia L. 2018. Antioxidation, anti-hyperglycaemia and renoprotective effects of extracellular polysaccharides from Pleurotus eryngii SI-04. International Journal of Biological Macromolecules, 111, 219–228.
Zhang J, Wen C, Duan Y, Zhang H, Ma H. 2019. Advance in Cordyceps militaris (Linn) Link polysaccharides: Isolation, structure, and bioactivities: A review. International Journal of Biological Macromolecules, 132, 906–914.
Zhang L, Liu Y, Ke Y, Liu Y, Luo X, Li C, Zhang Z, Liu A, Shen L, Chen H, Hu B, Wu H, Wu W, Lin D, Li S. 2018. Antidiabetic activity of polysaccharides from Suillellus luridus in streptozotocin-induced diabetic mice. International Journal of Biological Macromolecules, 119, 134–140.
Zhang M, Cheung P, Zhang L. 2001. Evaluation of mushroom dietary fiber (nonstarch polysaccharides) from sclerotia of Pleurotus tuber-regium (Fries) Singer as a potential antitumor agent. Journal of Agricultural and Food Chemistry, 49, 5059–5062.
Zhang M, Zhang L, Cheung P C K, Ooi V E C. 2004. Molecular weight and anti-tumor activity of the water-soluble polysaccharides isolated by hot water and ultrasonic treatment from the sclerotia and mycelia of Pleurotus tuber-regium. Carbohydrate Polymers, 56, 123–128.
Zhang S, Nie S, Huang D, Feng Y, Xie M. 2014. A novel polysaccharide from Ganoderma atrum exerts antitumor activity by activating mitochondria-mediated apoptotic pathway and boosting the immune system. Journal of Agricultural and Food Chemistry, 62, 1581–1589.
Zhang T, Zhao W, Xie B, Liu H. 2020. Effects of Auricularia auricula and its polysaccharide on diet-induced hyperlipidemia rats by modulating gut microbiota. Journal of Functional Foods, 72, 104038.
Zhang X, Qi C, Guo Y, Zhou W, Zhang Y. 2016. Toll-like receptor 4-related immunostimulatory polysaccharides: Primary structure, activity relationships, and possible interaction models. Carbohydrate Polymers, 149, 186–206.
Zhang Y, He Z, Liu X, Chen Z, Sun J, Wu Z, Yang X, Chen X, Tang Z, Wang K. 2019. Oral administration of Angelica sinensis polysaccharide protects against pancreatic islets failure in type 2 diabetic mice: Pancreatic β-cell apoptosis inhibition. Journal of Functional Foods, 54, 361–370.
Zhang Y, Hu T, Zhou H, Zhang Y, Jin G, Yang Y. 2016. Antidiabetic effect of polysaccharides from Pleurotus ostreatus in streptozotocin-induced diabetic rats. International Journal of Biological Macromolecules, 83, 126–132.
Zhang Y, Li Q, Shu Y, Wang H, Zheng Z, Wang J, Wang K. 2015. Induction of apoptosis in S180 tumour bearing mice by polysaccharide from Lentinus edodes via mitochondria apoptotic pathway. Journal of Functional Foods, 15, 151–159.
Zhang Y, Li S, Wang X, Zhang L, Cheung P C K. 2011. Advances in lentinan: Isolation, structure, chain conformation and bioactivities. Food Hydrocolloids, 25, 196–206.
Zhang Y, Wang Z, Jin G, Yang X, Zhou H. 2017. Regulating dyslipidemia effect of polysaccharides from Pleurotus ostreatus on fat-emulsion-induced hyperlipidemia rats. International Journal of Biological Macromolecules, 101, 107–116.
Zhang Y, Zhang Z, Liu H, Wang D, Wang J, Deng Z, Li T, He Y, Yang Y, Zhong S. 2020. Physicochemical characterization and antitumor activity in vitro of a selenium polysaccharide from Pleurotus ostreatus. International Journal of Biological Macromolecules, 165, 2934–2946.
Zhang Y Z, Sun D J, Meng Q J, Guo W X, Chen Q H, Zhang Y. 2017. Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway. International Journal of Molecular Medicine, 40, 1089–1095.
Zhao H, Li S, Zhang J, Che G, Zhou M, Liu M, Zhang C, Xu N, Lin L, Liu Y, Jia L. 2016. The antihyperlipidemic activities of enzymatic and acidic intracellular polysaccharides by Termitomyces albuminosus. Carbohydrate Polymers, 151, 1227–1234.
Zhao J, Niu X, Yu J, Xiao X, Li W, Zang L, Hu Z, Siu-Po I P P, Li W. 2020. Poria cocos polysaccharides attenuated ox-LDL-induced inflammation and oxidative stress via ERK activated Nrf2/HO-1 signaling pathway and inhibited foam cell formation in VSMCs. International Immunopharmacology, 80, 106173.
Zhao L, Dong Y, Chen G, Hu Q. 2010. Extraction, purification, characterization and antitumor activity of polysaccharides from Ganoderma lucidum. Carbohydrate Polymers, 80, 783–789.
Zhao R, Hu Q, Ma G, Su A, Xie M, Li X, Chen G, Zhao L. 2019. Effects of Flammulina velutipes polysaccharide on immune response and intestinal microbiota in mice. Journal of Functional Foods, 56, 255–264.
Zhao S, Rong C, Liu Y, Xu F, Wang S, Duan C, Chen J, Wu X. 2015. Extraction of a soluble polysaccharide from Auricularia polytricha and evaluation of its anti-hypercholesterolemic effect in rats. Carbohydrate Polymers, 122, 39–45.
Zheng J, Li C, Wu X, Liu M, Sun X, Yang Y, Hao M, Sheng S, Sun Y, Zhang H, Long J, Liang Y, Hu C. 2014. Huaier polysaccharides suppresses hepatocarcinoma MHCC97-H cell metastasis via inactivation of EMT and AEG-1 pathway. International Journal of Biological Macromolecules, 64, 106–110.
Zheng J, Yang B, Yu Y, Chen Q, Huang T, Li D. 2012. Ganoderma lucidum polysaccharides exert anti-hyperglycemic effect on streptozotocin-induced diabetic rats through affecting β-cells. Combinatorial Chemistry & High Throughput Screening, 15, 542–550.
Zheng L, Zhai G, Zhang J, Wang L, Ma Z, Jia M, Jia L. 2014. Antihyperlipidemic and hepatoprotective activities of mycelia zinc polysaccharide from Pholiota nameko SW-02. International Journal of Biological Macromolecules, 70, 523–529.
Zheng Y, Bai L, Zhou Y, Tong R, Zeng M, Li X, Shi J. 2019. Polysaccharides from Chinese herbal medicine for anti-diabetes recent advances. International Journal of Biological Macromolecules, 121, 1240–1253.
Zheng Y, Wang W D, Li Y. 2015. Antitumor and immunomodulatory activity of polysaccharide isolated from Trametes orientalis. Carbohydrate Polymers, 131, 248–254.
Zhong M, Zhong C, Hu P, Cui W, Wang G, Gao H, Liu C, Liu Z, Li Z, Li C, Gohda E. 2018. Restoration of stemness-high tumor cell-mediated suppression of murine dendritic cell activity and inhibition of tumor growth by low molecular weight oyster polysaccharide. International Immunopharmacology, 65, 221–232.
Zhou L B, Chen B. 2011. Bioactivities of water-soluble polysaccharides from Jisongrong mushroom: anti-breast carcinoma cell and antioxidant potential. International Journal of Biological Macromolecules, 48, 1–4.
Zhu K X, Nie S P, Tan L H, Li C, Gong D M, Xie M Y. 2016. A polysaccharide from Ganoderma atrum improves liver function in type 2 diabetic rats via antioxidant action and short-chain fatty acids excretion. Journal of Agricultural and Food Chemistry, 64, 1938–1944.
Zhu M, Nie P, Liang Y, Wang B. 2013. Optimizing conditions of polysaccharide extraction from Shiitake mushroom using response surface methodology and its regulating lipid metabolism. Carbohydrate Polymers, 95, 644–648.
Zong A, Cao H, Wang F. 2012. Anticancer polysaccharides from natural resources: A review of recent research. Carbohydrate Polymers, 90, 1395–1410.