Journal of Integrative Agriculture ›› 2026, Vol. 25 ›› Issue (7): 2903-2914.DOI: 10.1016/j.jia.2025.06.021

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纳米农药与生物防治的协同应用：对寄生蜂表现出优异生物相容性，实现高效蚜虫防控

  

  • 收稿日期:2025-04-29 修回日期:2025-06-18 接受日期:2025-05-20 出版日期:2026-07-20 发布日期:2026-06-09

Synergistic incorporation of nano-pesticides into biological control: Excellent biocompatibility with parasitic wasps (Aphidius colemani) can achieve efficient aphid control

Shangyuan Wu1*, Qinhong Jiang1*, Leiyang Li1, Jia He2, Ying Wei1, Meizhen Yin3, Jie Shen1, Hu Li1#, Shuo Yan1#   

  1. 1 State Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, China Agricultural University, Beijing 100193, China

    2 Ningxia Key Lab of Plant Disease and Pest Control, Institute of Plant Protection, Ningxia Academy of Agriculture and Forestry Science, Yinchuan 750002, China

    3 State Key Laboratory of Chemical Resource Engineering, Beijing Lab of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China

  • Received:2025-04-29 Revised:2025-06-18 Accepted:2025-05-20 Online:2026-07-20 Published:2026-06-09
  • About author:#Correspondence Hu Li, E-mail: tigerleecau@hotmail.com; Shuo Yan, E-mail: yanshuo2011@foxmail.com * These authors contributed equally to this study.
  • Supported by:

    This research was funded by the Key R&D Program of Ningxia Hui Autonomous Region, China (2024BBF02010), the Technology Innovation Guidance Project of Ningxia Academy of Agriculture and Forestry Sciences, China (NKYG-24-18), the China National Tobacco Corporation of Science and Technology Major Projects (110202401012 [LS-02]) and the 2115 Talent Development Program of China Agricultural University.

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摘要：

化学农药与生物天敌协同应用在病虫害防控中面临一个根本性挑战：如何在确保防控效果的同时实现生态安全。近年来，纳米技术作为一种新兴策略，在提升农药性能、减少农药残留和缓解环境污染方面展现出广阔前景。本研究构建了一种基于星型阳离子聚合物（SPc）负载噻虫胺的高效纳米农药，并与广泛应用的寄生蜂，粗脊蚜茧蜂（Aphidius colemani ）联合施用，实现了虫害的协同防控。实验表明，SPc 在工作浓度下对寄生蜂的羽化率和存活率无显著影响，而在极高浓度下经饲喂法处理，显著上调了与核糖体蛋白及能量代谢相关的多个基因，导致代谢失衡，进而引发寄生蜂死亡。SPc 可通过氢键和范德华力与噻虫胺自发形成复合物，将粒径由6554.87 nm 缩小至 467.84 nm。并且，噻虫胺/SPc 复合物对蚜虫（Myzus persicae）的毒力提升了16–28%，同时对寄生蜂的羽化和寄生率几乎无不良影响。最终，该复合物与寄生蜂协同施用可实现对蚜虫高达80%的致死率，展现出快速抑制害虫种群数量和可持续控制的双重优势。本研究提出了一种基于纳米农药与天敌协同施用的病虫害治理策略，有助于实现农业生态系统的长期稳定与平衡。

Abstract: The synergistic use of chemical pesticides and biological agents poses the fundamental challenge of balancing control efficacy with ecological safety.  In recent years, nanotechnology has emerged as a promising strategy for improving pesticide performance while reducing pesticide residues and alleviating environmental contamination.  Herein, we developed an efficient nano-pesticide based on star polycation (SPc) loaded with clothianidin, which was co-applied with a widely used parasitic wasp (Aphidius colemani) to achieve synergistic pest management.  SPc at the working concentration displayed no significant impact on the eclosion or survival of parasitic wasps, whereas the oral feeding of SPc at an extremely high concentration significantly up-regulated several genes related to ribosomal protein and energy metabolism, leading to metabolic imbalance and subsequent mortality of the parasitic wasps.  The SPc could load clothianidin via hydrogen bonding and Van der Waals forces, and this spontaneous complexation achieved a reduction in particle size from 6,554.87 to 467.84 nm.  Importantly, the clothianidin/SPc complex exhibited a 16–28% increase in insecticidal activity against green peach aphids (Myzus persicae), while showing minimal adverse impacts on the eclosion and parasitism of parasitic wasps.  Finally, co-application of the clothianidin/SPc complex with parasitic wasps achieved up to 80% mortality in green peach aphids, with the promising advantages of rapid pest suppression and sustainable control.  This study proposes a synergetic pest management strategy based on nano-pesticides and natural enemies, which is beneficial for maintaining long-term agricultural ecological balance.

Key words: biological control , cooperative control , nano-pesticide , parasitic wasp , pest management