Journal of Integrative Agriculture ›› 2026, Vol. 25 ›› Issue (6): 2268-2287.DOI: 10.1016/j.jia.2025.07.020
-
收稿日期:2024-10-11修回日期:2025-07-16接受日期:2025-04-08出版日期:2026-06-20发布日期:2026-05-06
Recent advances in genomic studies for domestication and genetic improvement of traits in goats
Zhanerke Akhatayeva1, 3, Hongying Dan2, Hosein Salehian-Dehkordi1, 2, Talgat Seiteuov4, Abdugani Abdurasulov5, Rustembay Aitjanov6, Kejian Lin1#, Songsong Xu2#
1 Institute of Grassland Research, Chinese Academy of Agricultural Sciences, Hohhot 010010, China
2 College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
3 LPP “Kazakh Research Institute of Animal Husbandry and Fodder Production”, Almaty 050071, Kazakhstan
4 Faculty of Agricultural Science, Toraighyrov University, Pavlodar 140008, Kazakhstan
5 Department of Veterinary Medicine and Biotechnology, Osh State University, Osh 723500, Kyrgyzstan
6 Department of Zooingeneering, Nukus branch of the Samarkand State Veterinary Medicine Livestock and Biotechnology University, Karakalpakstan 230100, Uzbekistan
-
Received:2024-10-11Revised:2025-07-16Accepted:2025-04-08Online:2026-06-20Published:2026-05-06 -
About author:#Correspondence Songsong Xu, E-mail: xusongsong@cau.edu.cn; Kejian Lin, E-mail: linkejian@caas.cn -
Supported by:This work was supported by the National Key Research and Development Program of China (2022YFE0113300), the Project of Northern Agriculture and Livestock Husbandry Technology Innovation Center, Chinese Academy of Agricultural Sciences (BFGJ2022002), the National Key Research and Development Program of China (2021YFD1200900, 2023YFF1001003, and 2023YFF1000900), the Biological Breeding-National Science and Technology Major Project, China (2023ZD0407106), the National Natural Science Foundation of China (32102511, 31661143014, 31972527, 32320103006, and 32272845), and the Chinese Universities Scientific Fund (2024TC162).
引用本文
Zhanerke Akhatayeva, Hongying Dan, Hosein Salehian-Dehkordi, Talgat Seiteuov, Abdugani Abdurasulov, Rustembay Aitjanov, Kejian Lin, Songsong Xu. [J]. Journal of Integrative Agriculture, 2026, 25(6): 2268-2287.
Zhanerke Akhatayeva, Hongying Dan, Hosein Salehian-Dehkordi, Talgat Seiteuov, Abdugani Abdurasulov, Rustembay Aitjanov, Kejian Lin, Songsong Xu. Recent advances in genomic studies for domestication and genetic improvement of traits in goats[J]. Journal of Integrative Agriculture, 2026, 25(6): 2268-2287.
| Abioja M O, Logunleko M O, Majekodunmi B C, Adekunle E O, Shittu O O, Odeyemi A J, Nwosu E U, Oke O E, Iyasere O S, Abiona J A, Williams T J, James I J, Smith O F, Daramola J O. 2023. Roles of candidate genes in the adaptation of goats to heat stress: A review. Small Ruminant Research, 218, 106878. Al-Qahtani A A, Alhamlan F S, Al-Qahtani A A. 2024. Pro-Inflammatory and anti-inflammatory interleukins in infectious diseases: A comprehensive review. Tropical Medicine and Infectious Disease, 9, 13. Amills M, Capote J, Tosser‐Klopp G. 2017. Goat domestication and breeding: A jigsaw of historical, biological and molecular data with missing pieces. Animal Genetics, 48, 631–644. An X, Hou J, Gao T, Lei Y, Li G, Song Y, Wang J, Cao B. 2015a. Single-nucleotide polymorphisms g.151435C>T and g.173057T>C in PRLR gene regulated by bta-miR-302a are associated with litter size in goats. Theriogenology, 83, 1477–1483.e1. An X, Ma T, Hou J, Fang F, Han P, Yan Y, Zhao H, Song Y, Wang J, Cao B. 2013a. Association analysis between variants in KISS1 gene and litter size in goats. BMC Genetics, 14, 63. An X P, Hou J X, Lei Y N, Gao T Y, Song Y X, Wang J G, Cao B Y. 2015b. Two mutations in the 5´-flanking region of the KITLG gene are associated with litter size of dairy goats. Animal Genetics, 46, 308–311. An X P, Hou J X, Li G, Song Y X, Wang J G, Chen Q J, Cui Y H, Wang Y F, Cao B Y. 2012. Polymorphism identification in the goat KITLG gene and association analysis with litter size. Animal Genetics, 43, 104–107. An X P, Hou J X, Zhao H B, Li G, Bai L, Peng J Y, M Yan Q, Song Y X, Wang J G, Cao B Y. 2013b. Polymorphism identification in goat GNRH1 and GDF9 genes and their association analysis with litter size. Animal Genetics, 44, 234–238. Baysoy A, Bai Z, Satija R, Fan R. 2023. The technological landscape and applications of single-cell multi-omics. Nature reviews. Molecular Cell Biology, 24, 695–713. Berihulay H, Li Y, Liu X, Gebreselassie G, Islam R, Liu W, Jiang L, Ma Y. 2019. Genetic diversity and population structure in multiple Chinese goat populations using a SNP panel. Animal Genetics, 50, 242–249. Bernard V, Young J, Chanson P, Binart N. 2015. New insights in prolactin: pathological implications. Nature Reviews Endocrinology, 11, 265–275. Bertolini F, Servin B, Talenti A, Rochat E, Kim E S, Oget C, Palhière I, Crisà A, Catillo G, Steri R, Amills M, Colli L, Marras G, Milanesi M, Nicolazzi E, Rosen B D, Van Tassell C P, Guldbrandtsen B, Sonstegard T S, Tosser-Klopp G, et al. 2018. AdaptMap consortium. Signatures of selection and environmental adaptation across the goat genome post-domestication. Genetics, Selection, Evolution, 50, 57. Bhuiyan A A, Li J, Wu Z, Ni P, Adetula A A, Wang H, Zhang C, Tang X. Bhuyan A A, Zhao S, Du X. 2017. Exploring the genetic resistance to gastrointestinal nematodes infection in goat using RNA-sequencing. International Journal of Molecular Sciences, 18, 751. Bi Y, Feng W, Kang Y, Wang K, Yang Y, Qu L, Chen H, Lan X, Pan C. 2021a. Detection of mRNA expression and copy number variations within the goat FecB gene associated with litter size. Frontiers in Veterinary Science, 8, 758705. Bi Y, Zhang S, Li J, He L, Kang Y, Chen H, Lan X, Pan C. 2021b. The mRNA expression profile of the goat prion protein testis-specific (PRNT) gene and its associations with litter size. Theriogenology, 165, 69–75. Bian P, Li J, Zhou S, Wang X, Gong M, Guo X, Cai Y, Yang Q, Fu J, Li R, Huang S, Luo F, Shah A M, Lenstra J A, Mwacharo J M, Li R, Ren G, Wang X, Li C, Zheng W, et al. 2024. A graph-based goat pangenome reveals structural variations involved in domestication and adaptation. Molecular Biology and Evolution, 41, msae251. Bickhart D M, Rosen B D, Koren S, Sayre B L, Hastie A R, Chan S, Lee J, Lam E T, Liachko I, Sullivan S T, Burton J N, Huson H J, Nystrom J C, Kelley C M, Hutchison J L, Zhou Y, Sun J, Crisà A, Ponce de León F A, Schwartz J C, et al. 2017. Single-molecule sequencing and chromatin conformation capture enable de novo reference assembly of the domestic goat genome. Nature Genetics, 49, 643–650. Brito L F, Kijas J W, Ventura R V, Sargolzaei M, Porto-Neto L R, Cánovas A, Feng Z, Jafarikia M, Schenkel F S. 2017. Genetic diversity and signatures of selection in various goat breeds revealed by genome-wide SNP markers. BMC Genomics, 18, 229. Chang L, Zheng Y, Li S, Niu X, Huang S, Long Q, Ran X, Wang J. 2024. Identification of genomic characteristics and selective signals in Guizhou black goat. BMC Genomics, 25, 164. Chen M, Yan H, Wang K, Cui Y, Chen R, Liu J, Zhu H, Qu L, Pan C. 2019. Goat SPEF2: Expression profile, indel variants identification and association analysis with litter size. Theriogenology, 139, 147–155. Choi B Y. 2020. Targeting Wnt/β-catenin pathway for developing therapies for hair loss. International Journal of Molecular Sciences, 21, 4915. Ciesielska-Figlon K, Lisowska KA. 2024. The role of the CD28 family receptors in T-cell immunomodulation. International Journal of Molecular Sciences, 25, 1274. Cinar Kul B, Bilgen N, Lenstra JA, Korkmaz Agaoglu O, Akyuz B, Ertugrul O. 2015. Y-chromosomal variation of local goat breeds of Turkey close to the domestication centre. Journal of Animal Breeding and Genetics, 132, 449–453. Colli L, Lancioni H, Cardinali I, Olivieri A, Capodiferro M R, Pellecchia M, Rzepus M, Zamani W, Naderi S, Gandini F, Vahidi S M, Agha S, Randi E, Battaglia V, Sardina M T, Portolano B, Rezaei H R, Lymberakis P, Boyer F, Coissac E, et al. 2015. Whole mitochondrial genomes unveil the impact of domestication on goat matrilineal variability. BMC Genomics, 16, 1115. Consortium V, Nijman I J, Rosen B D, Bardou P, Faraut T, Cumer T, Daly K G, Zheng Z, Cai Y, Asadollahpour H, Kul B Ç, Zhang W Y, E G X, Ayin A, Baird H, Bakhtin M, Bâlteanu V A, Barfield D, Berger B, Blichfeldt T, et al. 2022. Geographical contrasts of Y‐chromosomal haplogroups from wild and domestic goats reveal ancient migrations and recent introgressions. Molecular Ecology, 31, 4364–4380. Cosenza G, Albarella S, D’Anza E, Iannuzzi A, Selvaggi M, Pugliano M, Galli T, Saralli G, Ciotola F, Peretti V. 2023. A new AS-PCR method to detect CSN201 allele, genotyping at ca-sensitive caseins loci and milk traits association studies in autochthonous Lazio goats. Animals, 13, 239. Daei-Farshbaf N, Aflatoonian R, Amjadi F, Nikniyaz H, Taleahmad S, Bakhtiyari M. 2021. Identification of calcineurin as a predictor of oocyte quality and fertilization competence based on microarray data. Computational Biology and Chemistry, 94, 107561. Dai L, An D, Huang J, Xiao M, Li Z, Zhou B, Liu H, Xu J, Chen X, Ruan Y. 2024. Ovarian multi-omics analysis reveals key rate-limiting enzymes FASN, SCD5, FADS1, 3BHSD, and STAR as potential targets for regulating kidding traits in goats. International Journal of Biological Macromolecules, 282, 136737. Daly K G, Mattiangeli V, Hare A J, Davoudi H, Fathi H, Doost S B, Amiri S, Khazaeli R, Decruyenaere D, Nokandeh J, Richter T, Darabi H, Mortensen P, Pantos A, Yeomans L, Bangsgaard P, Mashkour M, Zeder M A, Bradley D G. 2021. Herded and hunted goat genomes from the dawn of domestication in the Zagros Mountains. Proceedings of the National Academy of Sciences of the United States of America, 118, e2100901118. Deniskova T E, Dotsev A V, Selionova M I, Reyer H, Sölkner J, Fornara M S, Aybazov A M, Wimmers K, Brem G, Zinovieva N A. 2021. SNP-based genotyping provides insight into the West Asian origin of Russian local goats. Frontiers in Genetics, 12, 708740. Dettori M L, Pazzola M, Noce A, Landi V, Vacca G M. 2023. Variations in casein genes are associated with milk protein and fat contents in Sarda goats (Capra hircus), with an important role of CSN1S2 for milk yield. Animals, 14, 56. D’Mello S, Finlay G, Baguley B, Askarian-Amiri M. 2016. Signaling pathways in melanogenesis. International Journal of Molecular Science, 17, 1144. Dong Y, Zhang X, Xie M, Arefnezhad B, Wang Z, Wang W, Feng S, Huang G, Guan R, Shen W, Bunch R, McCulloch R, Li Q, Li B, Zhang G, Xu X, Kijas J W, Salekdeh G H, Wang W, Jiang Y. 2015. Reference genome of wild goat (Capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication. BMC Genomics, 16, 431. Fernández H, Hughes S, Vigne J D, Helmer D, Hodgins G, Miquel C, Hänni C, Luikart G, Taberlet P. 2006. Divergent mtDNA lineages of goats in an Early Neolithic site, far from the initial domestication areas. Proceedings of the National Academy of Sciences of the United States of America, 103, 15375–15379. Gao J, Lyu Y, Zhang D, Reddi K K, Sun F, Yi J, Liu C, Li H, Yao H, Dai J, Xu F. 2020. Genomic characteristics and selection signatures in indigenous Chongming White goat (Capra hircus). Frontiers in Genetics, 11, 901. Gao Y, Wang X, Yan H, Zeng J, Ma S, Niu Y, Zhou G, Jiang Y, Chen Y. 2016. Comparative transcriptome analysis of fetal skin reveals key genes related to hair follicle morphogenesis in cashmere goats. PLoS ONE, 11, e0151118. Ge W, Zhang W, Zhang Y, Zheng Y, Li F, Wang S, Liu J, Tan S, Yan Z, Wang L, Shen W, Qu L, Wang X. 2021. A single-cell transcriptome atlas of cashmere goat hair follicle morphogenesis. Genomics, Proteomics, Bioinformatics, 19, 437–451. Geng R, Yuan C, Chen Y. 2013. Exploring differentially expressed genes by RNA-seq in cashmere goat (capra hircus) skin during hair follicle development and cycling. PLoS ONE, 8, e62704. Gong G, Lin T, Yuan Y. 2020. Integrated analysis of gene expression and DNA methylation profiles in ovarian cancer. Journal of Ovarian Research, 13, 30. Gu C, Fan X, Yu W. 2023. Functional diversity of mammalian small heat shock proteins: A review. Cells, 12, 1947. Guan D, Martínez A, Luigi‐Sierra M G, Delgado J V, Landi V, Castelló A, Fernández Álvarez J, Such X, Jordana J, Amills M. 2021. Detecting the footprint of selection on the genomes of Murciano‐Granadina goats. Animal Genetics, 52, 683–693. Guo J, Sun X, Mao A, Liu H, Zhan S, Li L, Zhong T, Wang L, Cao J, Liu G E, Zhang H. 2022. A 13.42-kb tandem duplication at the ASIP locus is strongly associated with the depigmentation phenotype of non-classic Swiss markings in goats. BMC Genomics, 23, 437. Hayes B J, Chen C, Powell O, Dinglasan E, Villiers K, Kemper K E, Hickey L T. 2023. Advancing artificial intelligence to help feed the world. Nature Biotechnology, 41, 1188–1189. Henkel J, Saif R, Jagannathan V, Schmocker C, Zeindler F, Bangerter E, Herren U, Posantzis D, Bulut Z, Ammann P, Drögemüller C, Flury C, Leeb T. 2019. Selection signatures in goats reveal copy number variants underlying breed-defining coat color phenotypes. Plos Genetics, 15, e1008536. Higgins C A, Petukhova L, Harel S, Ho Y Y, Drill E, Shapiro L, Wajid M, Christiano A M. 2014. FGF5 is a crucial regulator of hair length in humans. Proceedings of the National Academy of Sciences of the United States of America, 111, 10648–10653. Hoekstra H E. 2006. Genetics, development and evolution of adaptive pigmentation in vertebrates. Heredity, 97, 222–234. Hou J X, An X P, Han P, Peng J Y, Cao B Y. 2015. Two missense mutations in exon 9 of caprine PRLR gene were associated with litter size. Animal Genetics, 46, 87–90. Hu X, Hao F, Li X, Xun Z, Gao Y, Ren B, Cang M, Liang H, Liu D. 2021. Generation of VEGF knock-in Cashmere goat via the CRISPR/Cas9 system. International Journal of Biological Sciences, 17, 1026–1040. Hui Y, Zhang Y, Wang K, Pan C, Chen H, Qu L, Song X, Lan X. 2020. Goat DNMT3B: An indel mutation detection, association analysis with litter size and mRNA expression in gonads. Theriogenology, 147, 108–115. Hutt K J, McLaughlin E A, Holland M K. 2006. Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis. Molecular Human Reproduction, 12, 61–69. Jeet V, Magotra A, Bangar Y C, Kumar S, Garg A R, Yadav A S, Bahurupi P. 2022. Evaluation of candidate point mutation of Kisspeptin 1 gene associated with litter size in Indian Goat breeds and its effect on transcription factor binding sites. Domestic Animal Endocrinology, 78, 106676. Jin M, Lu J, Fei X, Lu Z, Quan K, Liu Y, Chu M, Di R, Wei C, Wang H. 2020. Selection signatures analysis reveals genes associated with high-altitude adaptation in Tibetan goats from Nagqu, Tibet. Animals, 10, 1599. Joshi M B, Rout P K, Mandal A K, Tyler-Smith C, Singh L, Thangaraj K. 2003. Phylogeography and origin of Indian domestic goats. Molecular Biology and Evolution, 21, 454–462. Juengel J L, Bibby A H, Reader K L, Lun S, Quirke L D, Haydon L J, McNatty K P. 2004. The role of transforming growth factor-beta (TGF-beta) during ovarian follicular development in sheep. Reproductive Biology and Endocrinology, 2, 78. Kalds P, Zhou S, Cai B, Liu J, Wang Y, Petersen B, Sonstegard T, Wang X, Chen Y. 2019. Sheep and goat genome engineering: From random transgenesis to the CRISPR era. Frontiers in Genetics, 10, 750. Kang Z, Bai Y, Lan X, Zhao H. 2021. Goat AKAP12: Indel mutation detection, association analysis with litter size and alternative splicing variant expression. Frontiers in Genetics, 12, 648256. Kang Z, Jiang E, Wang K, Pan C, Chen H, Yan H, Zhu H, Liu J, Qu L, Lan X. 2019a. Goat membrane associated ring-CH-type finger 1 (MARCH1) mRNA expression and association with litter size. Theriogenology, 128, 8–16. Kang Z, Zhang S, He L, Zhu H, Wang Z, Yan H, Huang Y, Dang R, Lei C, Chen H, Qu L, Lan X, Pan C. 2019b. A 14-bp functional deletion within the CMTM2 gene is significantly associated with litter size in goat. Theriogenology, 139, 49–57. Kappes A, Tozooneyi T, Shakil G, Railey A F, McIntyre K M, Mayberry D E, Rushton J, Pendell D L, Marsh T L. 2023. Livestock health and disease economics: A scoping review of selected literature. Frontiers in Veterinary Science, 10, 1168649. Kaushik R, Goel A, Rout P K. 2022. Differential expression and regulation of HSP70 gene during growth phase in ruminants in response to heat stress. Scientific Reports, 12, 18310. Khan I, Maldonado E, Vasconcelos V, O’Brien S J, Johnson W E, Antunes A. 2014. Mammalian keratin associated proteins (KRTAPs) subgenomes: Disentangling hair diversity and adaptation to terrestrial and aquatic environments. BMC Genomics, 15, 779. Kumar A, Kaur M, Ahlawat S, Sharma U, Singh M K, Singh K V, Chhabra P, Vijh R K, Yadav A, Arora R. 2021. Transcriptomic diversity in longissimus thoracis muscles of Barbari and Changthangi goat breeds of India. Genomics, 113, 1639–1646. Kumar C, Song S, Dewani P, Kumar M, Parkash O, Ma Y, Malhi K K, Yang N, Mwacharo J M, He X, Jiang L. 2018. Population structure, genetic diversity and selection signatures within seven indigenous Pakistani goat populations. Animal Genetics, 49, 592–604. Kumari N, Vasisth R, Gurao A, Mukesh M, Vohra V, Kumar S, Kataria R S. 2023. ASIP gene polymorphism associated with black coat and skin color in Murrah buffalo. Environmental and Molecular Mutagenesis, 64, 309–314. Lee M Y Y, Kaestner K H, Li M. 2023. Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data. Genome Biology, 24, 244. Li M, Yin S, Yuan J, Wei L, Ai J S, Hou Y, Chen D Y, Sun Q Y. 2008. Cdc25A promotes G 2 /M transition in oocytes. Cell Cycle, 7, 1301–1302. Li R, Fu W, Su R, Tian X, Du D, Zhao Y, Zheng Z, Chen Q, Gao S, Cai Y, Wang X, Li J, Jiang Y. 2019. Towards the complete goat pan-genome by recovering missing genomic segments from the reference genome. Frontiers in Genetics, 10, 1169. Li R, Yang P, Dai X, Asadollahpour Nanaei H, Fang W, Yang Z, Cai Y, Zheng Z, Wang X, Jiang Y. 2021. A near complete genome for goat genetic and genomic research. Genetics, Selection, Evolution, 53, 74. Li X, Hao F, Hu X, Wang H, Dai B, Wang X, Liang H, Cang M, Liu D. 2019. Generation of Tβ4 knock-in Cashmere goat using CRISPR/Cas9. International Journal of Biological Sciences, 15, 1743–1754. Li X, Su R, Wan W, Zhang W, Jiang H, Qiao X, Fan Y, Zhang Y, Wang R, Liu Z, Wang Z, Liu B, Ma Y, Zhang H, Zhao Q, Zhong T, Di R, Jiang Y, Chen W, Wang W, et al. 2017. Identification of selection signals by large-scale whole-genome resequencing of cashmere goats. Scientific Reports, 7, 15142. Liang C, Han M, Zhou Z, Liu Y, He X, Jiang Y, Ouyang Y, Hong Q, Chu M. 2021. Hypothalamic transcriptome analysis reveals the crucial microRNAs and mRNAs affecting litter size in goats. Frontiers in Veterinary Science, 8, 747100. Lin Y, Sun L, Lv Y, Liao R, Zhang K, Zhou J, Zhang S, Xu J, He M, Wu C, Zhang D, Shen X, Dai J, Gao J. 2024. Transcriptomic and metabolomic dissection of skeletal muscle of crossbred Chongming white goats with different meat production performance. BMC Genomics, 25, 443. Liu J, Shi Y, Mo D, Luo L, Xu S, Lv F. 2024. The goat pan-genome reveals patterns of gene loss during domestication. Journal of Animal Science and Biotechnology, 15, 132. Liu X, Zheng J, Ding J, Wu J, Zuo F, Zhang G. 2024. When livestock genomes meet third-generation sequencing technology: From opportunities to applications. Genes, 15, 245. Luikart G, Gielly L, Excoffier L, Vigne J D, Bouvet J, Taberlet P. 2001. Multiple maternal origins and weak phylogeographic structure in domestic goats. Proceedings of the National Academy of Sciences of the United States of America, 98, 5927–5932. Mahmoudi P, Rashidi A, Nazari-Ghadikolaei A, Rostamzadeh J, Razmkabir M, Huson H J. 2022. Genome-wide association study reveals novel candidate genes for litter size in Markhoz goats. Frontiers Veterinary Science, 9, 1045589. Martin P, Palhière I, Maroteau C, Bardou P, Canale-Tabet K, Sarry J, Woloszyn F, Bertrand-Michel J, Racke I, Besir H, Rupp R, Tosser-Klopp G. 2017. A genome scan for milk production traits in dairy goats reveals two new mutations in Dgat1 reducing milk fat content. Scientific Reports, 7, 1872. Martin P M, Palhière I, Ricard A, Tosser-Klopp G, Rupp R. 2016. Genome wide association study identifies new loci associated with undesired coat color phenotypes in Saanen goats. PLoS ONE, 11, e0152426. Massender E, Brito L F, Schenkel F S. 2022. Sustainable genetic improvement in dairy goats. In: Encyclopedia of Sustainability Science and Technology. Springer, New York, NW. pp. 1–17. Massender E, Oliveira H R, Brito L F, Maignel L, Jafarikia M, Baes C F, Sullivan B, Schenkel F S. 2023. Genome-wide association study for milk production and conformation traits in Canadian Alpine and Saanen dairy goats. Journal of Dairy Science, 106, 1168–1189. Menzi F, Keller I, Reber I, Beck J, Brenig B, Schütz E, Leeb T, Drögemüller C. 2016. Genomic amplification of the caprine EDNRA locus might lead to a dose dependent loss of pigmentation. Scientific Reports, 6, 28438. Mucha S, Mrode R, Coffey M, Kizilaslan M, Desire S, Conington J. 2018. Genome-wide association study of conformation and milk yield in mixed-breed dairy goats. Journal of Dairy Science, 101, 2213–2225. Naderi S, Rezaei H R, Pompanon F, Blum M G B, Negrini R, Naghash H R, Balkız Ö, Mashkour M, Gaggiotti O E, Ajmone-Marsan P, Kence A, Vigne J D, Taberlet P. 2008. The goat domestication process inferred from large-scale mitochondrial DNA analysis of wild and domestic individuals. Proceedings of the National Academy of Sciences of the United States of America, 105, 17659–17664. Naderi S, Rezaei H R, Taberlet P, Zundel S, Rafat, S A, Naghash H R, El-Barody M A A, Ertugrul O, Pompanon F. 2007. Large-scale mitochondrial DNA analysis of the domestic goat reveals six haplogroups with high diversity. PLoS ONE, 2, e1012. Nomura K, Yonezawa T, Mano S, Kawakami S, Shedlock A M, Hasegawa M, Amano T. 2013. Domestication process of the goat revealed by an analysis of the nearly complete mitochondrial protein-encoding genes. PLoS ONE, 8, e67775. Notter D R. 2012. Genetic improvement of reproductive efficiency of sheep and goats. Animal Reproduction Science, 130, 147–151. Oget C, Servin B, Palhière I. 2019. Genetic diversity analysis of French goat populations reveals selective sweeps involved in their differentiation. Animal Genetics, 50, 54–63. Påhlman S, Mohlin S. 2018. Hypoxia and hypoxia-inducible factors in neuroblastoma. Cell and Tissue Research, 372, 269–275. Pan C, Li H, Mustafa S B, Renqing C, Zhang Z, Li J, Song T, Wang G, Zhao W. 2024. Coping with extremes: The rumen transcriptome and microbiome co-regulate plateau adaptability of Xizang goat. BMC Genomics, 25, 258. Peng W, Zhang Y, Gao L, Shi W, Liu Z, Guo X, Zhang Y, Li B, Li G, Cao J, Yang M. 2024. Selection signatures and landscape genomics analysis to reveal climate adaptation of goat breeds. BMC Genomics, 25, 420. Pidancier N, Jordan S, Luikart G, Taberlet P. 2006. Evolutionary history of the genus Capra (Mammalia, Artiodactyla): Discordance between mitochondrial DNA and Y-chromosome phylogenies. Molecular Phylogenetics and Evolution, 40, 739–749. Ramachandran N, Sejian V. 2022. Climate resilience of goat breeds in India: A review. Small Ruminant Research, 208, 106630. Scholtens M, Jiang A, Smith A, Littlejohn M, Lehnert K, Snell R, Lopez-Villalobos N, Garrick D, Blair H. 2020. Genome-wide association studies of lactation yields of milk, fat, protein and somatic cell score in New Zealand dairy goats. Journal of Animal Science and Biotechnology, 11, 55. Sevilla A, Grichnik J. 2024. Therapeutic modulation of KIT ligand in melanocytic disorders with implications for mast cell diseases. Experimental Dermatology, 33, e15091. Shen J, Hao Z, Wang J, Hu J, Liu X, Li S, Ke N, Song Y, Lu Y, Hu L, Qiao L, Wu X, Luo Y. 2021. Comparative transcriptome profile analysis of longissimus dorsi muscle tissues from two goat breeds with different meat production performance using RNA-seq. Frontiers in Genetics, 11, 619399. Signer-Hasler H, Henkel J, Bangerter E, Bulut Z, Drögemüller C, Leeb T, Flury C. 2022. Runs of homozygosity in Swiss goats reveal genetic changes associated with domestication and modern selection. Genetics, Selection, Evolution, 54, 6. Silver D L, Hou L, Somerville R, Young M E, Apte S S, Pavan W J. 2008. The secreted metalloprotease ADAMTS20 is required for melanoblast survival. Plos Genetics, 4, e1000003. Song N, Chen Y, Luo J, Huang L, Tian H, Li C, Loor J J. 2020. Negative regulation of αS1-casein (CSN1S1) improves β-casein content and reduces allergy potential in goat milk. Journal of Dairy Science, 103, 9561–9572. Song S, Yao N, Yang M, Liu X, Dong K, Zhao Q, Pu Y, He X, Guan W, Yang N, Ma Y, Jiang L. 2016. Exome sequencing reveals genetic differentiation due to high-altitude adaptation in the Tibetan cashmere goat (Capra hircus). BMC Genomics, 17, 122. Souza-Fabjan J M G, Oliveira M E F, Guimarães M P P, Brandão F Z, Bartlewski P M, Fonseca J F. 2023. Review: Non-surgical artificial insemination and embryo recovery as safe tools for genetic preservation in small ruminants. Animal, 17, 100787. Su R, Fan Y, Qiao X, Li X, Zhang L, Li C, Li J. 2018. Transcriptomic analysis reveals critical genes for the hair follicle of Inner Mongolia cashmere goat from catagen to telogen. PLoS ONE, 13, e0204404. Sultana S, Mannen H, Tsuji S. 2003. Mitochondrial DNA diversity of Pakistani goats. Animal Genetics, 34, 417–421. Sun Z, Liu Y, He X, Di R, Wang X, Ren C, Zhang Z, Chu M. 2022. Integrative proteomics and transcriptomics profiles of the oviduct reveal the prolificacy-related candidate biomarkers of goats (Capra hircus) in estrous periods. International Journal of Molecular Science, 23, 14888. Talouarn E, Bardou P, Palhière I, Oget C, Clément V, Tosser-Klopp G, Rupp R, Robert-Granié C. 2020. Genome wide association analysis on semen volume and milk yield using different strategies of imputation to whole genome sequence in French dairy goats. BMC Genetics, 21, 19. Tang Q, Zhang Y, Yang Y, Hu H, Lan X, Pan C. 2021. The KMT2A gene: mRNA differential expression in the ovary and a novel 13-nt nucleotide sequence variant associated with litter size in cashmere goats. Domestic Animal Endocrinology, 74, 106538. Tao L, He X Y, Jiang Y T, Lan R, Li M, Li Z M, Yang W F, Hong Q H, Chu M X. 2020. Combined approaches to reveal genes associated with litter size in Yunshang black goats. Animal Genetics, 51, 924–934. Tian H, Niu H, Luo J, Yao W, Chen X, Wu J, Geng Y, Gao W, Lei A, Gao Z, Tian X, Zhao X, Shi H, Li C, Hua J. 2022. Knockout of stearoyl-CoA desaturase 1 decreased milk fat and unsaturated fatty acid contents of the goat model generated by CRISPR/Cas9. Journal of Agricultural and Food Chemistry, 70, 4030–4043. Tosser-Klopp G, Bardou P, Bouchez O, Cabau C, Crooijmans R, Dong Y, Donnadieu-Tonon C, Eggen A, Heuven H C, Jamli S, Jiken A J, Klopp C, Lawley C T, McEwan J, Martin P, Moreno C R, Mulsant P, Nabihoudine I, Pailhoux E, Palhière I, et al. 2014. International Goat Genome Consortium. Design and characterization of a 52K SNP chip for goats. PLoS One, 9, e86227. Erratum in: PLoS One, 2016, 11, e0152632. Trüeb R M. 2018. Further clinical evidence for the effect of IGF-1 on hair growth and alopecia. Skin Appendage Disorders, 4, 90–95. Vacca G M, Dettori M L, Piras G, Manca F, Paschino P, Pazzola M. 2014. Goat casein genotypes are associated with milk production traits in the Sarda breed. Animal Genetics, 45, 723–731. Vázquez-Flores F, Montaldo H H, Torres-Vázquez J A, Alonso-Morales R A, Gayosso-Vázquez A, Valencia-Posadas M, Castillo-Juárez H. 2012. Additive and dominance effects of the α s1 -casein locus on milk yield and composition traits in dairy goats. Journal of Dairy Research, 79, 367–374. Vidal O, Drögemüller C, Obexer-Ruff G, Reber I, Jordana J, Martínez A, Bâlteanu V A, Delgado J V, Eghbalsaied S, Landi V, Goyache F, Traoré A, Pazzola M, Vacca G M, Badaoui B, Pilla F, D’Andrea M, Álvarez I, Capote J, Sharaf A, et al. 2017. Differential distribution of Y-chromosome haplotypes in Swiss and Southern European goat breeds. Scientific Reports, 7, 16161. Villani R, Hodgson S, Legrand J, Greaney J, Wong H Y, Pichol-Thievend C, Adolphe C, Wainwight B, Francois M, Khosrotehrani K. 2017. Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types. Development, 144, 1887–1895. Wang F H, Zhang L, Gong G, Yan X C, Zhang L T, Zhang F T, Liu H F, Lv Q, Wang Z Y, Wang R J, Zhang Y J, Wang Z X, Liu Z H, He L B, Su R, Zhao Y H, Li J Q. 2021. Genome‐wide association study of fleece traits in Inner Mongolia Cashmere goats. Animal Genetics, 52, 375–379. Wang J, Fu Y, Su T, Wang Y, Soladoye O P, Huang Y, Zhao Z, Zhao Y, Wu W. 2023. A role of multi-omics technologies in sheep and goat meats: Progress and way ahead. Foods, 12, 4069. Wang K, Kang Z, Jiang E, Yan H, Zhu H, Liu J, Qu L, Lan X, Pan C. 2020. Genetic effects of DSCAML1 identified in genome-wide association study revealing strong associations with litter size and semen quality in goat (Capra hircus). Theriogenology, 146, 20–25. Wang Q, Bi Y, Wang Z, Zhu H, Liu M, Wu X, Pan C. 2022. Goat SNX29: mRNA expression, InDel and CNV detection, and their associations with litter size. Frontiers in Veterinary Science, 9, 981315. Wang S, Li F, Liu J, Zhang Y, Zheng Y, Ge W, Qu L, Wang X. 2020. Integrative analysis of methylome and transcriptome reveals the regulatory mechanisms of hair follicle morphogenesis in cashmere goat. Cells, 9, 969. Wang W, Jin Z, Kong M, Yan Z, Fu L, Du X. 2024. Single-cell transcriptomic profiling unveils dynamic immune cell responses during haemonchus contortus infection. Cells, 13, 842. Wang X, Cai B, Zhou J, Zhu H, Niu Y, Ma B, Yu H, Lei A, Yan H, Shen Q, Shi L, Zhao X, Hua J, Huang X, Qu L, Chen Y. 2016. Correction: Disruption of FGF5 in cashmere goats using CRISPR/CAS9 results in more secondary hair follicles and longer fibers. PLoS ONE, 11, e0167322. Wang X, Niu Y, Zhou J, Zhu H, Ma B, Yu H, Yan H, Hua J, Huang X, Qu L, Chen Y. 2018. CRISPR/Cas9‐mediated MSTN disruption and heritable mutagenesis in goats causes increased body mass. Animal Genetics, 49, 43–51. Wang X, Yang Q, Wang K, Yan H, Pan C, Chen H, Liu J, Zhu H, Qu L, Lan X. 2019. Two strongly linked single nucleotide polymorphisms (Q320P and V397I) in GDF9 gene are associated with litter size in cashmere goats. Theriogenology, 125, 115–121. Wang X, Yang Q, Wang K, Zhang S, Pan C, Chen H, Qu L, Yan H, Lan X. 2017. A novel 12-bp indel polymorphism within the GDF9 gene is significantly associated with litter size and growth traits in goats. Animal Genetics, 48, 735–736. Wang Y, Zheng Y, Guo D, Zhang X, Guo S, Hui T, Yue C, Sun J, Guo S, Bai Z, Cai W, Zhang X, Fan Y, Wang Z, Bai W. 2020. m6A methylation analysis of differentially expressed genes in skin tissues of coarse and fine type Liaoning Cashmere goats. Frontiers in Genetics, 10, 1318. Wang Y H, Zhang C L, Plath M, Fang X T, Lan X Y, Zhou Y, Chen H. 2015. Global transcriptional profiling of longissimus thoracis muscle tissue in fetal and juvenile domestic goat using RNA sequencing. Animal Genetics, 46, 655–665. Wang Z, Pan Y, He L, Song X, Chen H, Pan C, Qu L, Zhu H, Lan X. 2020. Multiple morphological abnormalities of the sperm flagella (MMAF)-associated genes: The relationships between genetic variation and litter size in goats. Gene, 753, 144778. Wang Z, Wang R, Pan C, Chen H, Qu L, Wu L, Guo Z, Zhu H, Lan X. 2022. Genetic variations and mRNA expression of goat DNAH1 and their associations with litter size. Cells, 11, 1371. Wijayanti D, Zhang S, Yang Y, Bai Y, Akhatayeva Z, Pan C, Zhu H, Qu L, Lan X. 2022. Goat SMAD family member 1 (SMAD1): mRNA expression, genetic variants, and their associations with litter size. Theriogenology, 193, 11–19. Williams K, Ingerslev L R, Bork-Jensen J, Wohlwend M, Hansen A N, Small L, Ribel-Madsen R, Astrup A, Pedersen O, Auwerx J, Workman C T, Grarup N, Hansen T, Barrès R. 2020. Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism. Nature Communication, 11, 2695. Witt K E, Huerta-Sánchez E. 2019. Convergent evolution in human and domesticate adaptation to high-altitude environments. Philosophical Transactions of the Royal Society of London (Series B: Biological Sciences), 374, 20180235. Woo J, Suh W, Sung J H. 2022. Hair growth regulation by fibroblast growth factor 12 (FGF12). International Journal of Molecular Sciences, 23, 9467. Wu C, Li J, Xu X, Xu Q, Qin C, Liu G, Wei C, Zhang G, Tian K, Fu X. 2022. Effect of the FA2H gene on cashmere fineness of Jiangnan cashmere goats based on transcriptome sequencing. BMC Genomics, 23, 527. Wu C, Ma S, Zhao B, Qin C, Wu Y, Di J, Suo L, Fu X. 2023. Drivers of plateau adaptability in cashmere goats revealed by genomic and transcriptomic analyses. BMC Genomics, 24, 428. Wu H, Luo L Y, Zhang Y H, Zhang C Y, Huang J H, Mo D X, Zhao L M, Wang Z X, Wang Y C, He-Hua E, Bai W L, Han D, Dou X T, Ren Y L, Dingkao R, Chen H L, Ye Y, Du H D, Zhao Z Q, Wang X J, et al. 2024. Telomere-to-telomere genome assembly of a male goat reveals variants associated with cashmere traits. Nature Communications, 15, 10041. Xiao C, Li J, Xie T, Chen J, Zhang S, Elaksher S H, Jiang F, Jiang Y, Zhang L, Zhang W, Xiang Y, Wu Z, Zhao S, Du X. 2021. The assembly of caprine Y chromosome sequence reveals a unique paternal phylogenetic pattern and improves our understanding of the origin of domestic goat. Ecology and Evolution, 11, 7779–7795. Xin D, Bai Y, Bi Y, He L, Kang Y, Pan C, Zhu H, Chen H, Qu L, Lan X. 2021. Insertion/deletion variants within the IGF2BP2 gene identified in reported genome-wide selective sweep analysis reveal a correlation with goat litter size. Journal of Zhejiang University (Science B), 22, 757–766. Xu Y, Zhang Y, Qin Y, Gu M, Chen R, Sun Y, Wu Y, Li Q, Qiao Y, Wang X, Zhang Q, Kong L, Li S, Wang Z. 2023. Multi-omics analysis of functional substances and expression verification in cashmere fineness. BMC Genomics, 24, 720. Yang B G, Yuan Y, Zhou D K, Ma Y H, Mahrous K F, Wang S Z, He Y M, Duan X H, Zhang W Y, E G. 2021. Genome‐wide selection signal analysis of Australian Boer goat reveals artificial selection imprinting on candidate genes related to muscle development. Animal Genetics, 52, 550–555. Yang F, Liu Z, Zhao M, Mu Q, Che T, Xie Y, Ma L, Mi L, Li J, Zhao Y. 2020. Skin transcriptome reveals the periodic changes in genes underlying cashmere (ground hair) follicle transition in cashmere goats. BMC Genomics, 21, 392. Yang J, Wang D F, Huang J H, Zhu Q H, Luo L Y, Lu R, Xie X L, Salehian-Dehkordi H, Esmailizadeh A, Liu G E, Li M H. 2024. Structural variant landscapes reveal convergent signatures of evolution in sheep and goats. Genome Biology, 25, 148. Yang Y, Gomez N, Infarinato N, Adam R C, Sribour M, Baek I, Laurin M, Fuchs E. 2023. The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates. Nature Cell Biology, 25, 1185–1195. Yao X, Li J, Fu J, Wang X, Ma L, Nanaei H A, Shah A M, Zhang Z, Bian P, Zhou S, Wang A, Wang X, Jiang Y. 2025. Genomic landscape and prediction of udder traits in Saanen dairy goats. Animals, 15, 261. Yao Z, Zhang S, Wang X, Guo Y, Xin X, Zhang Z, Xu Z, Wang E, Jiang, Y, Huang Y. 2023. Genetic diversity and signatures of selection in BoHuai goat revealed by whole-genome sequencing. BMC Genomics, 24, 116. Yardman‐Frank J M, Fisher, D E. 2021. Skin pigmentation and its control: From ultraviolet radiation to stem cells. Experimental Dermatology, 30, 560–571. Zhang B, Chang L, Lan X, Asif N, Guan F, Fu D, Li B, Yan C, Zhang H, Zhang X, Huang Y, Chen H, Yu J, Li S. 2018. Genome-wide definition of selective sweeps reveals molecular evidence of trait-driven domestication among elite goat (Capra species) breeds for the production of dairy, cashmere, and meat. Giga Science, 7, giy105. Zhang C, Asadollahpour Nanaei H, Jafarpour Negari N, Amiri Roudbar M, Amiri Ghanatsaman Z, Niyazbekova Z, Yang X. 2024. Genomic analysis uncovers novel candidate genes related to adaptation to tropical climates and milk production traits in native goats. BMC Genomics, 25, 477. Zhang J, Cui M L, Nie Y W, Dai B, Li F R, Liu D J, Liang H, Cang M. 2018. CRISPR/Cas9-mediated specific integration of fat-1 at the goat MSTN locus. The FEBS Journal, 285, 2828–2839. Zhang X, Li W, Liu C, Peng X, Lin J, He S, Li X, Han B, Zhang N, Wu Y, Chen L, Wang L, Mayila, Huang J, Liu M. 2017. Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9. Scientific Reports, 7, 8149. Zhang X, Yuan R, Bai Y, Yang Y, Song X, Lan X, Pan C. 2023. A deletion mutation within the goat AKAP13 gene is significantly associated with litter size. Animal Biotechnology, 34, 350–356. Zhao B, Wu C, Sammad A, Ma Z, Suo L, Wu Y, Fu X. 2022. The fiber diameter traits of Tibetan cashmere goats are governed by the inherent differences in stress, hypoxic, and metabolic adaptations: An integrative study of proteome and transcriptome. BMC Genomics, 23, 191. Zhao J, Liu S, Zhou X, Zhang R, Li Y, Wang X, Chen Y. 2016. A non-synonymous mutation in GDF9 is highly associated with litter size in cashmere goats. Animal Genetics, 47, 630–631. Zheng Z, Wang X, Li M, Li Y, Yang Z, Wang X, Pan X, Gong M, Zhang Y, Guo Y, Wang Y, Liu J, Cai Y, Chen Q, Okpeku M, Colli L, Cai D, Wang K, Huang S, Sonstegard T S, et al. 2020. The origin of domestication genes in goats. Science Advances, 6, eaaz5216. |
| No related articles found! |
| 阅读次数 | ||||||
|
全文 |
|
|||||
|
摘要 |
|
|||||