Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens

doi:10.1016/S2095-3119(20)63301-9

Journal of Integrative Agriculture ›› 2020, Vol. 19 ›› Issue (9): 2294-2300.DOI: 10.1016/S2095-3119(20)63301-9

收稿日期:2020-07-05 出版日期:2020-09-01 发布日期:2020-08-04

Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens

ZENG Xian-ying^1*, CHEN Xiao-han^1*, MA Shu-jie¹, WU Jiao-jiao¹, BAO Hong-mei¹, PAN Shu-xin¹, LIU Yan-jing¹, DENG Guo-hua¹, SHI Jian-zhong¹, CHEN Pu-cheng¹, JIANG Yong-ping¹, LI Yan-bing¹, HU Jing-lei², LU Tong², MAO Sheng-gang², GUO Xing-fu², LIU Jing-li², TIAN Guo-bin¹, CHEN Hua-lan¹

¹ State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China
² Harbin Weike Biotechnology Development Company, Harbin 150069, P.R.China

Received:2020-07-05 Online:2020-09-01 Published:2020-08-04
Contact: Correspondence CHEN Hua-lan, Tel: +86-451-51997168, Fax: +86-451-51997166, E-mail: chenhualan@caas.cn; TIAN Guo-bin, Tel: +86-451-51051681, Fax: +86-451-51997166, E-mail: tianguobin@caas.cn
About author:ZENG Xian-ying, E-mail: zengxianying@caas.cn; * These authors contributed equally to this study.
Supported by:
This work was supported by the National Key R&D Program of China (2016YFD0501602, 2017YFD0500701, and 2016YFE0203200), the National Natural Science Foundation of China (3167131307), the China Agriculture Research System (CARS-41-G12), and Central Public-interest Scientific Institution Basal Research Fund (1610302017001).

摘要/Abstract

Abstract:

We developed an H5/H7 trivalent inactivated vaccine by using Re-11, Re-12, and H7-Re2 vaccine seed viruses, which were generated by reverse genetics and derived their HA genes from A/duck/Guizhou/S4184/2017(H5N6) (DK/GZ/S4184/17) (a clade 2.3.4.4d virus), A/chicken/Liaoning/SD007/2017(H5N1) (CK/LN/SD007/17) (a clade 2.3.2.1d virus), and A/chicken/Guangxi/SD098/2017(H7N9) (CK/GX/SD098/17), respectively. The protective efficacy of this novel vaccine and that of the recently used H5/H7 bivalent inactivated vaccine against different H5 and H7N9 viruses was evaluated in chickens. We found that the H5/H7 bivalent vaccine provided solid protection against the H7N9 virus CK/GX/SD098/17, but only 50–60% protection against different H5 viruses. In contrast, the novel H5/H7 trivalent vaccine provided complete protection against the H5 and H7 viruses tested. Our study underscores the importance of timely updating of vaccines for avian influenza control.

Key words: avian influenza , H5/H7 trivalent vaccine , Re-11 , Re-12 and H7-Re2 strains , protective efficacy

. [J]. Journal of Integrative Agriculture, 2020, 19(9): 2294-2300.

ZENG Xian-ying, CHEN Xiao-han, MA Shu-jie, WU Jiao-jiao, BAO Hong-mei, PAN Shu-xin, LIU Yan-jing, DENG Guo-hua, SHI Jian-zhong, CHEN Pu-cheng, JIANG Yong-ping, LI Yan-bing, HU Jing-lei, LU Tong, MAO Sheng-gang, GUO Xing-fu, LIU Jing-li, TIAN Guo-bin, CHEN Hua-lan. Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens[J]. Journal of Integrative Agriculture, 2020, 19(9): 2294-2300.

参考文献

Alexander D J, Brown I H. 2009. History of highly pathogenic avian influenza. Revue Scientifique et Technique, 28, 19–38.
Chen H L. 2009. H5N1 avian influenza in China. Science in China (Series C: Life Sciences), 52, 419–427.
Gao R B, Cao B, Hu Y W, Feng Z J, Wang D Y, Hu W F, Chen J, Jie Z J, Qiu H B, Xu K, Xu X W, Lu H Z, Zhu W F, Gao Z C, Xiang N J, Shen Y Z, He Z B, Gu Y, Zhang Z Y, Yang Y, et al. 2013. Human infection with a novel avian-origin influenza A (H7N9) virus. The New England Journal of Medicine, 368, 1888–1897.
Gu C Y, Zeng X Y, Song Y M, Li Y B, Liu L L, Kawaoka Y, Zhao D M, Chen H L. 2019. Glycosylation and an amino acid insertion in the head of hemagglutinin independently affect the antigenic properties of H5N1 avian influenza viruses. Science China (Life Sciences), 62, 76–83.
Hui D S C, Lee N, Chan P K S. 2017. Avian influenza A (H7N9) virus infections in humans across five epidemics in mainland China, 2013–2017. Journal of Thoracic Disease, 9, 4808–4811.
Imai M, Watanabe T, Kiso M, Nakajima N, Yamayoshi S, Iwatsuki-Horimoto K, Hatta M, Yamada S, Ito M, Sakai-Tagawa Y, Shirakura M, Takashita E, Fujisaki S, McBride R, Thompson A J, Takahashi K, Maemura T, Mitake H, Chiba S, Zhong G X, et al. 2017. A highly pathogenic avian H7N9 influenza virus isolated from a human is lethal in some ferrets infected via respiratory droplets. Cell Host & Microbe, 22, 615–626.
Li C J, Bu Z G, Chen H L. 2014. Avian influenza vaccines against H5N1 ‘bird flu’. Trends in Biotechnology, 32, 147–156.
Li Y B, Shi J Z, Zhong G X, Deng G X, Tian G B, Ge J Y, Zeng X Y, Song J S, Zhao D M, Liu L L, Jiang Y P, Guan Y T, Bu Z G, Chen H L. 2010. Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009. Journal of Virology, 84, 8389–8397.
OIE (World Organization for Animal Health). 2017. Highly pathogenic avian influenza, China. https://www.oie.int/wahis_2/public/wahid.php/Reviewreport/Review?reportid=23367
Qi W B, Jia W X, Liu D, Li J, Bi Y H, Xie S M, Li B, Hu T, Du Y Y, Xing L, Zhang J H, Zhang F C, Wei X M, Eden J S, Li H N, Tian H Y, Li W, Su G M, Lao G J, Xu C G, et al. 2018. Emergence and adaptation of a novel highly pathogenic H7N9 influenza virus in birds and humans from a 2013 Human-Infecting. Journal of Virology, 92, e00921–e00938.
Shi J Z, Deng G H, Kong H H, Gu C Y, Ma S J, Yin X, Zeng X Y, Cui P F, Chen Y, Yang H L, Wan X P, Wang X R, Liu L L, Chen P C, Jiang Y P, Liu J X, Guan Y T, Suzuki Y, Li M, Qu Z Y, et al. 2017. H7N9 virulent mutants detected in chickens in China pose an increased threat to humans. Cell Research, 27, 1409–1421.
Shi J Z, Deng G H, Liu P H, Zhou J P, Guan L Z, Li W H, Li X Y, Guo J, Wang G J, Fan J, Wang J L, Li Y Y, Jiang Y P, Liu L L, Tian G B, Li C J, Chen H L. 2013. Isolation and characterization of H7N9 viruses from live poultry markets-Implication of the source of current H7N9 infection in humans. Chinese Science Bulletin, 58, 1857–1863.
Shi J Z, Deng G H, Ma S J, Zeng X Y, Yin X, Li M, Zhang B, Cui P F, Chen Y, Yang H L, Wan X P, Liu L L, Chen P C, Jiang Y P, Guan Y T, Liu J X, Gu W L, Han S Y, Song Y M, Liang L B, et al. 2018. Rapid evolution of H7N9 highly pathogenic viruses that emerged in China in 2017. Cell Host & Microbe, 24, 558–568.
Swayne D E, Pavade G, Hamilton K, Vallat B, Miyagishima K. 2011. Assessment of national strategies for control of high-pathogenicity avian influenza and low-pathogenicity notifiable avian influenza in poultry, with emphasis on vaccines and vaccination. Revue Scientifique et Technique, 30, 839–870.
Tian G B, Zhang S H, Li Y B, Bu Z G, Liu P H, Zhou J P, Li C J, Shi J Z, Yu K Z, Chen H L. 2005. Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics. Virology, 341, 153–162.
WHO (World Health Organization). 2008. Update on avian influenza A (H5N1) virus infection in humans. The New England Journal of Medicine, 358, 261–273.
WHO (World Health Organization). 2011. Manual for the laboratory diagnosis and virological surveillance of influenza. World Health Organization. https://apps.who.int/iris/handle/10665/44518
WHO (World Health Organization). 2015. Evolution of the influenza A(H5) haemagglutinin: WHO/OIE/FAO H5 Working Group reports a new clade designated 2.3.4.4. https://www.who.int/influenza/gisrs_laboratory/h5_nomenclature_clade2344/en/
WHO (World Health Organization). 2017. Monthly Risk Assessment Summary. https://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_10_30_2017.pdf?ua=1
WHO (World Health Organization). 2020. Cumulative number of confirmed human cases of avian influenza A(H5N1) reported to WHO. https://www.who.int/influenza/human_animal_interface/H5N1_cumulative_table_archives/en/
Wu J, Ke C W, Lau E H Y, Song Y C, Cheng K L, Zou L R, Kang M, Peiris M, Yen H L. 2019. Influenza H5/H7 Virus vaccination in poultry and reduction of zoonotic infections, Guangdong Province, China, 2017–18. Emerging Infectious Diseases, 25, 116–18.
Zeng X Y, Chen P C, Liu L L, Deng G H, Li Y B, Shi J Z, Kong H H, Feng H P, Bai J, Li X, Shi W J, Tian G B, Chen H L. 2016. Protective efficacy of an H5N1 inactivated vaccine against challenge with lethal H5N1, H5N2, H5N6, and H5N8 influenza viruses in chickens. Avian Diseases, 60, 253–255.
Zeng X Y, Tian G B, Shi J Z, Deng G H, Li C J, Chen H L. 2018. Vaccination of poultry successfully eliminated human infection with H7N9 virus in China. Science China (Life Sciences), 61, 1465–1473.
Zhang Q Y, Shi J Z, Deng G H, Guo J, Zeng X Y, He X J, Kong H H, Gu C Y, Li X Y, Liu J X, Wang G J, Chen Y, Liu L L, Liang L B, Li Y B, Fan J, Wang J L, Li W H, Guan L Z, Li Q M, et al. 2013. H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science, 341, 410–414.
Zhou J F, Wang D Y, Gao R B, Zhao B H, Song J D, Qi X, Zhang Y J, Shi Y L, Yang L, Zhu W F, Bai T, Qin K, Lan Y, Zou S M, Guo J F, Dong J, Dong L B, Zhang Y, Wei H J, Li X D, et al. 2013. Biological features of novel avian influenza A (H7N9) virus. Nature, 499, 500–503.

Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens

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