Journal of Integrative Agriculture ›› 2026, Vol. 25 ›› Issue (5): 1741-1759.DOI: 10.1016/j.jia.2025.12.036

• •    下一篇

水稻合成生物学研究进展:从主粮优化到功能超越

  

  • 收稿日期:2025-07-07 修回日期:2025-12-22 接受日期:2025-10-29 出版日期:2026-05-20 发布日期:2026-04-08

Advances in rice synthetic biology: Toward a better staple crop and beyond

Chenchen Zhang, Yan Wang, Lu Chen, Xixi Wang, Sheng Teng#   

  1. Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation/College of Life Sciences, China Jiliang University, Hangzhou 310018, China
  • Received:2025-07-07 Revised:2025-12-22 Accepted:2025-10-29 Online:2026-05-20 Published:2026-04-08
  • About author:Chenchen Zhang, E-mail: zcshiyu@163.com; #Correspondence Sheng Teng, E-mail: steng@cjlu.edu.cn
  • Supported by:

    We acknowledge the financial support from the Natural Science Foundation of Zhejiang Province, China (LD24C130002 and LQN25C020001) and the National Natural Science Foundation of China (32400208).

摘要:

合成生物学是一门运用工程学原理设计并构建新型生物系统或生命体的交叉学科。合成生物学最初以微生物系统为主要研究对象,目前已拓展至植物体系。植物合成生物学为应对农业与人口健康领域的全球性挑战提供了富有前景的解决方案。水稻作为全球主要粮食作物及植物科学研究的模式物种,已成为该领域的关键研究平台。近年来,研究人员在基于多重基因组编辑的基因组工程、新一代杂交稻的合成、无融合生殖的诱导、光合与固氮途径的重构,以及微量营养素、药物分子、治疗性蛋白与多肽的生物合成等方面取得了重要进展。本文系统综述了水稻合成生物学领域的最新研究成果,总结了当前发展态势,并对未来研究方向进行了展望。

Abstract:

Synthetic biology is an interdisciplinary field that applies engineering principles to design and construct novel biological systems or organisms.  Initially focused on microbial systems, its applications have expanded to include plants.  Plant synthetic biology offers promising solutions to pressing global challenges in agriculture and human health.  As a staple crop for much of the world’s population and a model species in plant science, rice has emerged as a pivotal platform in this domain.  Significant progress has been achieved in genome engineering through multiplex genome editing, synthetic hybrid rice systems, induction of apomixis, reconstruction of photosynthesis and nitrogen-fixation pathways, and biosynthesis of micronutrients, pharmaceuticals, and therapeutic proteins or peptides.  This review summarizes recent advances in rice synthetic biology, outlines current developments, and discusses future research directions.

Key words: rice synthetic biology , multiplex genome editing , synthetic hybrid rice , engineered pathways , endosperm bioreactor