Alphaherpesvirus-vectored vaccines against animal diseases: Current progress

doi:10.1016/S2095-3119(20)63175-6

Journal of Integrative Agriculture ›› 2020, Vol. 19 ›› Issue (8): 1928-1940.DOI: 10.1016/S2095-3119(20)63175-6

收稿日期:2019-04-28 出版日期:2020-08-01 发布日期:2020-06-21

Alphaherpesvirus-vectored vaccines against animal diseases: Current progress

HU Yang^{1, 2, 3*}, WANG Ming-shu^{1, 2, 3*}, CHENG An-chun^{1, 2, 3}, JIA Ren-yong^{1, 2, 3}, YANG Qiao^{1, 2, 3}, WU Ying^1, 2, 3, LIU Ma-feng^{1, 2, 3}, ZHAO Xin-xin^{1, 2, 3}, ZHU De-kang^{2, 3}, CHEN Shun^{1, 2, 3}, ZHANG Sha-qiu^{1, 2, 3}, WANG Yin², GAO Qun^{1, 2, 3}, OU Xu-min^{1, 2, 3}, MAO Sai^{1, 2, 3}, WEN Xing-jian^{1, 2, 3}, XU Zhi-wen², CHEN Zheng-li², ZHU Ling², LUO Qi-hui², TIAN Bin^{1, 3}, PAN Lei-chang^{1, 3}, Mujeeb Ur REHMAN^{1, 3}, LIU Yun-ya^{1, 2, 3}, YU Yan-ling^{1, 2, 3}, ZHANG Ling^{1, 2, 3}, CHEN Xiao-yue^{1, 2, 3}

¹ Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China
² Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R.China
³ Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, P.R.China

Received:2019-04-28 Online:2020-08-01 Published:2020-06-21
Contact: Correspondence CHENG An-chun, E-mail: chenganchun@vip.163.com
About author:HU Yang, E-mail: hy514103978@163.com; * These authors contributed equally to this study.
Supported by:
This work was supported by grants from the National Key Research and Development Program of China (2017YFD0500800), the earmarked fund for China Agriculture Research System (CARS-42-17), the Integration and Demonstration of Key Technologies for Goose Industrial Chain in Sichuan Province, China (2018NZ0005), and the Sichuan Veterinary Medicine and Drug Innovation Group of China Agriculture Research System (SCCXTD-2020-18).

摘要/Abstract

摘要：

重组病毒活载体疫苗是一种能够有效激活特异性和非特异性免疫、可多联多价、安全性好的新型疫苗。动物α疱疹病毒拥有较大的基因组，含有多个不影响病毒复制的非必需区，能够插入接受外源基因并表达相应抗原蛋白；同时具有较广泛的宿主谱，能够在宿主体内复制并持续刺激动物产生对抗相应病原的免疫力，是作为重组病毒活载体疫苗的理想载体。随着基因编辑技术的发展，可通过多种方法构建能够表达外源基因的重组病毒。目前以动物α疱疹病毒为载体的重组病毒活载体疫苗研究已经涉及禽类、猪、牛、羊、伴侣动物等，目前成功构建的多株重组动物α疱疹病毒能免疫后可使动物同时获得对多种疾病的免疫。本文总结了重组动物α疱疹病毒构建方法、外源基因的引入和表达以及动物α疱疹病毒活载体疫苗免疫作用三个方面的内容，包括了最新的基因编辑技术、不同的构建策略及其优缺点、外源基因的选择、插入形式和位点等，并介绍了各种动物α疱疹病毒活载体疫苗的最新研究进展，旨在为新型动物α疱疹病毒活载体疫苗的研究和开发提供一定的参考。

Abstract:

Recombinant virus-vectored vaccines are novel agents that can effectively activate specific and nonspecific immunity, are multivalent and multieffective, and have high safety ratings. Animal alphaherpesviruses have a large genome, contain multiple nonessential regions that do not affect viral replication and are capable of accepting the insertion of an exogenous gene and expressing the antigen protein. Furthermore, animal alphaherpesviruses have a wide host spectrum, can replicate in the host and continuously stimulate the animal to produce immunity to the corresponding pathogen, thus making them ideal carriers for recombinant virus-vectored vaccines. With the development of gene-editing technology, recombinant viruses capable of expressing foreign genes can be constructed by various methods. Currently, studies on recombinant virus-vectored vaccines constructed based on animal alphaherpesviruses have involved poultry, pigs, cattle, sheep, and companion animals. Studies have shown that the construction of recombinant animal alphaherpesviruses enables the acquisition of immunity to multiple diseases. This article mainly summarizes the current progress on animal alphaherpesvirus-vectored vaccines, aiming to provide reference for the development of new animal alphaherpesvirus-vectored vaccines.

Key words: recombinant vectored-vaccine , recombinant alphaherpesviruses , immunity , gene-editing , exogenous gene

. [J]. Journal of Integrative Agriculture, 2020, 19(8): 1928-1940.

HU Yang, WANG Ming-shu, CHENG An-chun, JIA Ren-yong, YANG Qiao, WU Ying, LIU Ma-feng, ZHAO Xin-xin, ZHU De-kang, CHEN Shun, ZHANG Sha-qiu, WANG Yin, GAO Qun, OU Xu-min, MAO Sai, WEN Xing-jian, XU Zhi-wen, CHEN Zheng-li, ZHU Ling, LUO Qi-hui, TIAN Bin, PAN Lei-chang, Mujeeb Ur REHMAN, LIU Yun-ya, YU Yan-ling, ZHANG Ling, CHEN Xiao-yue. Alphaherpesvirus-vectored vaccines against animal diseases: Current progress[J]. Journal of Integrative Agriculture, 2020, 19(8): 1928-1940.

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Alphaherpesvirus-vectored vaccines against animal diseases: Current progress

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