Journal of Integrative Agriculture ›› 2018, Vol. 17 ›› Issue (08): 1822-1832.DOI: 10.1016/S2095-3119(17)61839-2

• 论文 • 上一篇    下一篇

  

  • 收稿日期:2017-05-24 出版日期:2018-08-01 发布日期:2018-08-01

Pyraclostrobin-loaded poly (lactic-co-glycolic acid) nanospheres: Preparation and characteristics

YIN Ming-ming, ZHENG Yu, CHEN Fu-liang   

  1. Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China
  • Received:2017-05-24 Online:2018-08-01 Published:2018-08-01
  • Contact: Correspondence CHEN Fu-liang, E-mail: flchen@ippcaas.cn
  • About author:YIN Ming-ming, E-mail: mmyin@ippcaas.cn;
  • Supported by:
    This study was supported by the National Key R&D Program of China (2017YFD0200301, 2016YFD0200500).

Abstract:

We used poly (lactic-co-glycolic acid) (PLGA) as a carrier polymer for pyraclostrobin-loaded nanospheres.  Using the ultrasound emulsification-solvent evaporation method, the physicochemical characteristics and release properties of the pyraclostrobin-loaded nanospheres were studied by dialysis.  The optimal nanospheres prepared had a diameter of 0.6 μm, an active ingredient loading of 17.2%, and a loading rate of 89.7%.  Infrared spectroscopy data and differential scanning calorimetry revealed that pyraclostrobin was successfully embedded in the carrier PLGA, and photostability tests indicated enhanced ultraviolet resistance of pyraclostrobin-loaded PLGA nanospheres nanospheres.  Release property testing indicated that smaller particles had a faster release rate.  Nanospheres also had a faster release rate in slightly acidic and slightly basic environments than in a neutral condition.  Agitated nanospheres had a faster release rate than immobile nanospheres.  The cumulative release kinetics of pyraclostrobin-loaded nanospheres was consistent with the first order kinetic equation and the Weibull equation.

Key words: