Journal of Integrative Agriculture ›› 2013, Vol. 12 ›› Issue (3): 502-508.DOI: 10.1016/S2095-3119(13)60251-8

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Effects of High Fluoride and Low Iodine on Thyroid Function in Offspring Rats

 GE Ya-ming, NING Hong-mei, GU Xin-li, YIN Mei, YANG Xue-feng, QI Yong-hua , WANG Jundong   

  1. 1.College of Animal Science, Henan Institute of Science and Technology, Xinxiang 453003, P.R.China
    2.Shanxi Key Laboratory of Ecological Animal Science and Environmental Medicine, Shanxi Agricultural University, Taigu 030801,P.R.China
    3.College of Animal Science and Technology, Shihezi University, Shihezi 832000, P.R.China
  • 收稿日期:2011-10-21 出版日期:2013-03-01 发布日期:2013-03-10
  • 通讯作者: Correspondence WANG Jun-dong, E-mail: wangjd@sxau.edu.cn
  • 作者简介:GE Ya-ming, E-mail: ndgeyaming@126.com
  • 基金资助:

    This research was sponsored by the National Natural Science Foundation of China (30170681) and the Foundation of Henan Institute of Science and Technology, China (6007).

Effects of High Fluoride and Low Iodine on Thyroid Function in Offspring Rats

 GE Ya-ming, NING Hong-mei, GU Xin-li, YIN Mei, YANG Xue-feng, QI Yong-hua , WANG Jundong   

  1. 1.College of Animal Science, Henan Institute of Science and Technology, Xinxiang 453003, P.R.China
    2.Shanxi Key Laboratory of Ecological Animal Science and Environmental Medicine, Shanxi Agricultural University, Taigu 030801,P.R.China
    3.College of Animal Science and Technology, Shihezi University, Shihezi 832000, P.R.China
  • Received:2011-10-21 Online:2013-03-01 Published:2013-03-10
  • Contact: Correspondence WANG Jun-dong, E-mail: wangjd@sxau.edu.cn
  • About author:GE Ya-ming, E-mail: ndgeyaming@126.com
  • Supported by:

    This research was sponsored by the National Natural Science Foundation of China (30170681) and the Foundation of Henan Institute of Science and Technology, China (6007).

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摘要： Thirty-two Wistar rats were divided randomly into four groups of eight with six females and two males in each group. The rats were exposed to high fluoride drinking water (45 mg F- L-1 from 100 mg NaF L-1), low dietary iodine (0.0855 mg kg-1), or both together in order to assess the effects of these three regimens on the thyroid function of the offspring rats. After the animal model was established, the offspring rats were bred and 10-, 20-, 30-, 60-, and 90-d-old rats were used for the experiment. The treatments for the offspring rats were the same as those of their parents. In comparison with control rats, the relative thyroid glands were changed by three regimens, but the mean values of thyroid weight in the experimental groups saw no marked difference. Serum TT3 levels were increased in all stages in the low iodine (LI) group. In the high fluoride (HiF) group, increase in TT3 levels was observed except in 20-d-old rats. Decrease in TT3 at 20- and 90-d and increase in TT3 at 30- and 60-d were found in HiF+LI group. Serum TT4 levels first saw an increase, and then dropped in the LI and HiF+LI group. However, an increase in TT4 was found in the HiF group. The levels of TSH in serum rocketed at d 20, and then dropped in the next stages in experimental groups. The results suggested that thyroid disorder could be induced by high flroride in drinking water, low iodine diet, or both of them. Exposure time to fluoride or low iodine diet was one of the important factors that fluoride can induce the development of thyroid dyfunction.

关键词: high fluoride , iodine deficiency , offspring rats , thyroid function

Abstract: Thirty-two Wistar rats were divided randomly into four groups of eight with six females and two males in each group. The rats were exposed to high fluoride drinking water (45 mg F- L-1 from 100 mg NaF L-1), low dietary iodine (0.0855 mg kg-1), or both together in order to assess the effects of these three regimens on the thyroid function of the offspring rats. After the animal model was established, the offspring rats were bred and 10-, 20-, 30-, 60-, and 90-d-old rats were used for the experiment. The treatments for the offspring rats were the same as those of their parents. In comparison with control rats, the relative thyroid glands were changed by three regimens, but the mean values of thyroid weight in the experimental groups saw no marked difference. Serum TT3 levels were increased in all stages in the low iodine (LI) group. In the high fluoride (HiF) group, increase in TT3 levels was observed except in 20-d-old rats. Decrease in TT3 at 20- and 90-d and increase in TT3 at 30- and 60-d were found in HiF+LI group. Serum TT4 levels first saw an increase, and then dropped in the LI and HiF+LI group. However, an increase in TT4 was found in the HiF group. The levels of TSH in serum rocketed at d 20, and then dropped in the next stages in experimental groups. The results suggested that thyroid disorder could be induced by high flroride in drinking water, low iodine diet, or both of them. Exposure time to fluoride or low iodine diet was one of the important factors that fluoride can induce the development of thyroid dyfunction.

Key words: high fluoride , iodine deficiency , offspring rats , thyroid function