微小RNA介导意大利蜜蜂工蜂对东方蜜蜂微孢子虫的跨界调控

杜宇,范小雪,蒋海宾,王杰,冯睿蓉,张文德,余岢骏,隆琦,蔡宗兵,熊翠玲,郑燕珍,陈大福,付中民,徐国钧,郭睿

MicroRNA-Mediated Cross-Kingdom Regulation of Apis mellifera ligustica Worker to Nosema ceranae

DU Yu,FAN XiaoXue,JIANG HaiBin,WANG Jie,FENG RuiRong,ZHANG WenDe,YU KeJun,LONG Qi,CAI ZongBing,XIONG CuiLing,ZHENG YanZhen,CHEN DaFu,FU ZhongMin,XU GuoJun,GUO Rui

表2 靶向NcCK vs NcT1中病原毒力因子/侵染因子相关下调DEmRNA的AmCK1 vs AmT1中宿主显著上调miRNA的信息概要

Table 2 Summary of host up-regulated miRNAs in AmCK1 vs AmT1 targeting virulence factor/infection factor-associated pathogen significantly down-regulated mRNAs in NcCK vs NcT1

差异表达miRNA ID DEmiRNA ID 差异表达miRNA的log2FC log2FC of DEmiRNA 差异表达miRNA的P值 P value of DEmiRNA AmCK1组中的TPM值 TPM in AmCK1 group AmT1组中的TPM值 TPM in AmT1 group ame-miR-6052 11.7271 0.0021 0.0010 3.3900 miR-196-x 2.3757 0.0012 3.2800 17.0233 miR-16-y 2.7925 0.0421 0.5100 3.5333 miR-20-x 1.9111 0.0500 2.2733 8.5500 miR-21-y 2.2041 0.0000 12.6300 58.1967 miR-28-y 1.6298 0.0072 7.7467 23.9733 miR-30-y 2.1421 0.0034 6.3900 28.2067 miR-374-y 4.7301 0.0009 0.2033 5.3967 miR-590-y 3.6286 0.0325 0.1900 2.3500 miR-8212-y 11.4683 0.0036 0.0010 2.8333 novel-m0007-5p 2.9010 0.0223 0.4900 3.6600 miR-144-x 4.2291 0.0307 0.3933 7.3767 miR-454-y 3.5531 0.0306 0.2033 2.3867 ame-miR-193 3.1393 0.0039 0.9167 8.0767 miR-100-y 3.3495 0.0003 1.0367 10.5667 miR-193-y 2.8593 0.0049 0.8833 6.4100 miR-221-y 1.3376 0.0444 9.6667 24.4300 miR-222-y 1.8682 0.0000 100.1467 365.6167 miR-767-x 4.7167 0.0011 0.2033 5.3467 miR-8232-x 3.7159 0.0226 0.1900 2.4967 miR-29-y 1.5049 0.0014 29.6800 84.2333