BLV-miRNA跨界调控人类靶基因预测及生物信息学分析

王雍,李思妍,何思锐,张迪,连帅,王建发,武瑞

Prediction and Bioinformatics Analysis of BLV-miRNA Transboundary Regulation of Human Target Genes

WANG Yong,LI SiYan,HE SiRui,ZHANG Di,LIAN Shuai,WANG JianFa,WU Rui

表9 参与调控人乳腺癌的候选靶基因

Table 9 Candidate target genes involved in the regulation of human breast cancer

序号 Score 基因名称 Gene name miRNA miRNA 评分 Score 与乳腺癌关系 Relationship with breast cancer 1 NOTCH3 BLV-miR-B1-3p 600 在癌症转移过程中起作用[41] Playing a vital role in cancer metastasis 2 RICTOR BLV-miR-B1-3p 592 在癌症转移过程中起作用[42, 51] Playing a vital role in cancer metastasis 3 RPS6KA5 BLV-miR-B1-3p 618 调节乳腺癌中腔细胞分化和转移性休眠,增加骨归巢和生长能力,与肿瘤侵袭有关[40] It regulates the differentiation of luminal cells and metastatic dormancy in breast cancer, increases bone homing and growth capacity and is related to tumor invasion 4 OBSCN BLV-miR-B1-5p 2921 OBSCN缺失会导致细胞间接触被破坏,在体内外均会导致肿瘤的发生,迁移和侵袭[25] These cells contacts are disrupted by OBSCN defecting and leaded to cancer cell migration and invasion in vivo and in vitro 5 COL1A1 BLV-miR-B4-3p 2603 癌症来源的miR-218通过调控COL1A1在血液水平上乳腺癌向骨的转移过程起作用[49] MiR-218 of cancer work in transfer process with breast cancer metastasis to bone at the blood level by regulatory COL1A1 6 OBSCN BLV-miR-B5-5p 1061 OBSCN缺失会导致细胞间接触被破坏,在体内外均会导致肿瘤的发生,迁移和侵袭[25] These cells contacts are disrupted by OBSCN defecting and leaded to cancer cell migration and invasion in vivo and in vitro 7 ATF3 BLV-miR-B2-5p 180 乳腺癌期间的病理状况下,已经观察到ATF3的持续和延长表达[52] ATF3 will prolonge and sustaine expression under pathological situations in breast cancer