BLV-miRNA跨界调控人类靶基因预测及生物信息学分析

王雍,李思妍,何思锐,张迪,连帅,王建发,武瑞

Prediction and Bioinformatics Analysis of BLV-miRNA Transboundary Regulation of Human Target Genes

WANG Yong,LI SiYan,HE SiRui,ZHANG Di,LIAN Shuai,WANG JianFa,WU Rui

表8 参与调控人急性淋巴细胞白血病的候选靶基因

Table 8 Candidate target genes involved in the regulation of human acute lymphoblastic leukemia

序号 Score 基因名称 Gene name miRNA miRNA 评分 Score 与白血病关系 Relationship with leukemia 1 COL1A1 BLV-miR-B4-3p 2603 ALL患者的骨骼发育异常与Col1A1 Sp1结合位点基因多态性存在相关性[49] There is a correlation between ALL patients have dysfunctional bone development and Col1A1 Sp1 binding site gene polymorphism 2 BCR BLV-miR-B4-3p 320 ALL的融合转录本[50] The fusion transcripts of ALL