BLV-miRNA跨界调控人类靶基因预测及生物信息学分析
王雍,李思妍,何思锐,张迪,连帅,王建发,武瑞

Prediction and Bioinformatics Analysis of BLV-miRNA Transboundary Regulation of Human Target Genes
WANG Yong,LI SiYan,HE SiRui,ZHANG Di,LIAN Shuai,WANG JianFa,WU Rui
表7 参与细胞迁移/侵袭的候选靶基因
Table 7 Candidate target genes involved in cell migration / invasion
序号
Score
基因名称
Gene name
miRNA
miRNA
评分
Score
与迁移关系
Relationship with migration
1 NOTCH3 BLV-miR-B1-3p 600 促进转移[41] Promoting metastasis
2 RICTOR BLV-miR-B1-3p 592 促癌细胞转移[42] Promoting metastasis of cancer cells
3 TNXB BLV-miR-B1-3p 747 具有抗黏附作用
4 RPS6KA5 BLV-miR-B1-3p 618 肿瘤侵袭有关[30] Relating to tumor invasion
5 FOCAD BLV-miR-B3-3p 446 FOCAD编码一种在胶质瘤中具有肿瘤抑制功能的粘着斑蛋白[43]
FOCAD encodes a focal adhesion proteins of an tumor inhibitory function in glioma
6 PLEKHG3 BLV-miR-B3-3p 444 激活细胞前端的肌动蛋白丝来增强极化细胞迁移[44]
Activating the actin filaments at the cell front for enhancing the polarized migration of cells
7 EPPK1 BLV-miR-B3-5p 920 在伤口愈合期间加速角质形成细胞迁移
Promoting keratinocyte migration during wound healing
8 COL16A1 BLV-miR-B3-5p 1031 COL16A1在炎症晚期时在肠上皮下肌成纤维细胞(ISEMF)表面表达增加,导致细胞扩散[45]
COL16A1 expression increasing in cell surface which led to cell diffusion
9 COL1A2 BLV-miR-B4-3p 2543 促进胃癌细胞迁移和侵袭[38] Promoting cell migration and invasion in gastric cancer cells
10 TRO BLV-miR-B4-3p 1374 介导滋养细胞和子宫内膜上皮细胞之间的细胞黏附
It mediates cell adhesion between endometrial epithelial cells and trophoblast
11 CDC42 BLV-miR-B4-5p 925 影响细胞间黏附、肿瘤细胞形成过程的细胞迁移和侵袭[20]
Affecting cell adhesion and cell migration and invasion during the tumor cell formation
12 EPN1 BLV-miR-B4-5p 1506 可能降低癌细胞稳定性 It may have decreased cancer cells stability
13 LTBP3 BLV-miR-B4-5p 1074 促进癌细胞传播过程中的早期转移[46] Promoting metastasis in cancer cells of early phase
14 DNAH17 BLV-miR-B5-3p 320 DNAH17编码动力蛋白轴索重链,参与细胞运动[47]
DNAH17 encodes a dynein heavy chain motor protein and participates in cell motility
15 ATP11A BLV-miR-B2-3p 563 编码的蛋白质是完整的膜,是结直肠癌异时转移的独立预测因子[48]
The protein encoded was an independent predictor of colorectal cancer metastasis
16 ENPP7 BLV-miR-B2-3p 580 编码的蛋白质锚定在细胞膜中,它可能起到保护肠黏膜免受炎症和肿瘤发生的作用
It protects the intestinal mucosa against injuries inflammation and tumorigenesis to encoding protein which is anchored to the inner face of cellular membrane