BLV-miRNA跨界调控人类靶基因预测及生物信息学分析

王雍,李思妍,何思锐,张迪,连帅,王建发,武瑞

Prediction and Bioinformatics Analysis of BLV-miRNA Transboundary Regulation of Human Target Genes

WANG Yong,LI SiYan,HE SiRui,ZHANG Di,LIAN Shuai,WANG JianFa,WU Rui

表5 参与细胞增殖/凋亡的候选靶基因

Table 5 Candidate target genes involved in cell proliferation

序号 Number 基因名称 Gene name miRNA miRNA 评分 Score 与增殖关系 Relationship with proliferation 1 RPS6KA5 BLV-miR-B1-3p 618 抑制细胞增殖[30] Inhibiting of cell proliferation 2 SHPRH BLV-miR-B1-3p 590 抑制细胞增殖[31] Inhibiting of cell proliferation 3 EVC BLV-miR-B1-5p 2266 该基因发生突变可能通过下调Hh途径活性导致心肌细胞的增殖能力降低[32]。心肌细胞的抗细胞凋亡能力降低[32] Mutation of this gene may reduce the proliferation of cardiomyocytes by down-regulating Hh pathway activity. The anti-apoptotic ability of cardiomyocytes was decreased 4 BIRC6 BLV-miR-B2-3p 908 诱导细胞增殖[33]。抑制凋亡[34] Inducing cell proliferation and inhibiting apoptosis 5 EGFR BLV-miR-B2-3p 1049 诱导细胞增殖 Inducing cell proliferation 6 COL16A1 BLV-miR-B3-5p 1031 通过上调内皮受体VEGFR1,VEGFR2和uPAR触发血管生成[35] Angiogenesis is triggered by upregulation of endothelial receptors VEGFR1, VEGFR2, and uPAR 7 KMT2D BLV-miR-B3-5p 1203 下调抑制胃癌的增殖[36]。诱导其凋亡[36] Down-regulating gastric cancer proliferation and inducing apoptosis 8 TET3 BLV-miR-B4-3p 1691 细胞增殖[37] Cell proliferation 9 CDC42 BLV-miR-B4-5p 925 促进肿瘤生长[20] Promoting tumor growth 4 TRO BLV-miR-B4-3p 1374 通过PKC-δ诱导人子宫内膜上皮细胞的凋亡 Apoptosis of human endometrial epithelial cells was induced by PKC-δ 5 COL1A2 BLV-miR-B4-3p 2543 通过PI3K-Akt信号通路抑制胃癌细胞凋亡[38] The apoptosis of gastric cancer cells was inhibited by pi3K-Akt signaling pathway 6 COL3A1 BLV-miR-B4-3p 2098 拮抗细胞凋亡功能[19] Antagonizing apoptosis 7 TIAL1-201 BLV-miR-B2-5p 180 该基因编码的蛋白质是RNA结合蛋白家族的成员,调节各种活动,包括翻译控制,剪接和凋亡 The gene encodes proteins that are members of the RNA-binding protein family and regulate various activities, including translation control, splicing, and apoptosis