BLV-miRNA跨界调控人类靶基因预测及生物信息学分析
王雍,李思妍,何思锐,张迪,连帅,王建发,武瑞

Prediction and Bioinformatics Analysis of BLV-miRNA Transboundary Regulation of Human Target Genes
WANG Yong,LI SiYan,HE SiRui,ZHANG Di,LIAN Shuai,WANG JianFa,WU Rui
表4 参与合成细胞结构/骨架蛋白的候选靶基因
Table 4 Candidate target genes involved in the synthesis of cell structure / skeleton protein
序号
Number
基因名称
Gene name
miRNA
miRNA
评分
Score
与结构/骨架关系
Relationship with structure / skeleton
1 MYO19 BLV-miR-B1-3p 596 肌球蛋白,为肌肉收缩,胞质分裂和细胞器运输等过程提供动力[24]
It is myosin that powers muscle contraction, cytokinesis and organelle transport
2 BSN BLV-miR-B1-5p 2197 编码的tau蛋白是神经细胞的骨架成分
The encoded tau protein is a skeleton component of nerve cells
3 KLC1 BLV-miR-B1-5p 2308 与肌动蛋白重链结合、参与了囊泡、线粒体和高尔基体等物质的结合
It binds to actin heavy chains and is involved in the binding of vesicles, mitochondria and golgi bodies
4 OBSCN BLV-miR-B1-5p 2921 该基因编码的Obscurins蛋白可作为巨噬细胞的骨架蛋白[25]
Obscurins encoded by this gene can be regarded as the cytoskeleton protein of macrophages
5 EPPK1 BLV-miR-B3-5p 920 在细胞骨架结构中起作用[26]
It plays a role in the cytoskeletal structure
6 CDC42 BLV-miR-B4-5p 925 细胞骨架结构中发挥作用[20]
It plays a role in the cytoskeletal structure
7 LTBP3 BLV-miR-B4-5p 1074 编码的蛋白质与转化生长因子β(TGF-β)形成复合物,在细胞外基质中发挥结构作用
The encoded protein forms a complex with transforming growth factor β (TGF-β) and plays a structural role in the extracellular matrix
8 DNAJC14 BLV-miR-B5-3p 316 是一种热休克蛋白,有助于Hsp70介导的蛋白质折叠[27]
Is a heat shock protein that helps Hsp70-mediated protein folding
9 OBSCN BLV-miR-B5-5p 1061 该基因编码的Obscurins蛋白可作为巨噬细胞的骨架蛋白[25]
Obscurins encoded by this gene can be regarded as the cytoskeleton protein of macrophages
10 FNBP1L BLV-miR-B2-5p 1469 该基因编码的蛋白质与CDC42和N-WASP结合,通过激活N-WASP-WIP复合物来促进CDC42诱导的肌动蛋白聚合
The protein encoded by this gene binds to CDC42 and N-WASP, and promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex
11 GAS2L1-208 BLV-miR-B2-5p 178 该蛋白结合细胞骨架的成分,并可能参与介导微管和微丝之间的相互作用;GAS2L1,一种微管和肌动蛋白结合蛋白,参与中心粒动力学和中心体分离[28];Gas2是一种生长停滞特异性蛋白,是微丝网络系统的组成部分[29]
The protein binds to cytoskeletal components and is involved in mediating the interaction between microtubules and microfilaments. GAS2L1, a microtubule and actin binding protein, involved in centrosome dynamics and centrosome separation. Gas2 is a growth stagnation specific protein and a component of the microfilament network system
12 CLEC16A BLV-miR-B2-3p 439 该基因编码包含C型凝集素结构域的家族的成员
The gene encodes a member of a family that contains the type C lectin domain
13 HERC5-201 BLV-miR-B2-5p 175 该基因是泛素连接酶HERC家族的成员,编码具有HECT结构域和5个RCC1重复序列的蛋白质
The gene is a member of the ubiquitin ligase HERC family that encodes proteins with HECT domains and five RCC1 repeats
14 MAST1 BLV-miR-B2-3p 304 该基因是微管相关丝氨酸/苏氨酸激酶(MAST)家族的成员。由该基因编码的蛋白质具有N端丝氨酸/苏氨酸激酶结构域
This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family, and the protein encoded by this gene has an N-terminal serine/threonine kinase domain