BLV-miRNA跨界调控人类靶基因预测及生物信息学分析

王雍,李思妍,何思锐,张迪,连帅,王建发,武瑞

Prediction and Bioinformatics Analysis of BLV-miRNA Transboundary Regulation of Human Target Genes

WANG Yong,LI SiYan,HE SiRui,ZHANG Di,LIAN Shuai,WANG JianFa,WU Rui

表3 参与细胞信号转导的候选靶基因

Table 3 Candidate target genes involved in cell signal transduction

序号 Number 基因名称 Gene name miRNA miRNA 评分 Score 与信号转导关系 Relationship with signal transduction 1 NOTCH3 BLV-miR-B1-3p 600 编码果蝇I型膜蛋白缺口的人类同源物,建立细胞间信号传导途径,其在神经发育中起关键作用 The human homologues encoding gaps in Drosophila type I membrane proteins, establishing intercellular signal transduction pathways, which play a key role in neural development 2 MUC12 BLV-miR-B1-5p 4260 编码膜糖蛋白,在细胞内信号传导中发挥作用/黏液素在上皮表面形成的保护性黏液屏障中起重要作用 It encodes membrane glycoproteins and plays a role in intracellular signaling, and mucin plays an important role in the protective mucus barrier formed by the epithelial surface 3 MUC21 BLV-miR-B1-5p 3738 膜结合糖蛋白,在上皮表面形成保护性黏膜屏障中起重要作用,也在细胞内信号传导中起作用 Membrane-bound glycoproteins play an important role in the formation of a protective mucosal barrier on the epithelial surface and in intracellular signaling 4 ATF3 BLV-miR-B2-5p 180 编码哺乳动物激活转录因子;参与细胞应激反应 Encode mammalian activation transcription factors and participate in cellular stress response 5 NR2C2 BLV-miR-B2-5p 179 该基因编码属于核激素受体家族的蛋白质,该家族的成员充当配体激活的转录因子 The gene encodes proteins belonging to the nuclear hormone receptor family, members of which act as ligand-activated transcription factors 6 OR14I1 BLV-miR-B2-5p 187 负责识别和G蛋白介导的气味信号转导 Responsible for recognition and G protein-mediated odor signal transduction 7 POU3F3 BLV-miR-B2-3p 444 该基因编码含有POU结构域的蛋白质,该蛋白质起着转录因子的作用 The gene encodes a protein containing a POU domain, which acts as a transcription factor 8 TIAL1-201 BLV-miR-B2-5p 180 该基因编码的蛋白质是RNA结合蛋白家族的成员,调节各种活动,包括翻译控制,剪接和凋亡 The gene encodes proteins that are members of the RNA-binding protein family and regulate various activities including translation control, splicing, and apoptosis 9 TXNL1-204 BLV-miR-B2-5p 175 TXNL1- XRCC1是一种新型的调控途径,氧化还原传感器TXNL1在液相内吞中起调节作用[21] TXNL1- XRCC1 is a new regulatory approach, and the redox sensor TXNL1 plays a regulatory role in liquid phase endocytosis 10 MUC12 BLV-miR-B3-3p 1893 编码膜糖蛋白,在细胞内信号传导中发挥作用/黏液素在上皮表面形成的保护性黏液屏障中起重要作用 It encodes membrane glycoproteins and plays a role in intracellular signaling, and mucin plays an important role in the protective mucus barrier formed by the epithelial surface 11 AHNAK2 BLV-miR-B3-5p 6265 编码的蛋白质可通过与钙通道蛋白结合而在钙信号传导中起作用 The encoded protein can play a role in calcium signaling by binding to calcium channel proteins 12 EPN1 BLV-miR-B4-5p 1506 促进囊泡的内吞作用[22] Promoting endocytosis of vesicles 13 TSPAN14 BLV-miR-B4-5p 1052 作为跨膜蛋白,可调节内质网出口[23] As a transmembrane protein, it can regulate the export of endoplasmic reticulum 14 MUC12 BLV-miR-B4-5p 1045 编码膜糖蛋白,在细胞内信号传导中发挥作用/黏液素在上皮表面形成的保护性黏液屏障中起重要作用 It encodes membrane glycoproteins and plays a role in intracellular signaling, and mucin plays an important role in the protective mucus barrier formed by the epithelial surface 15 MUC12 BLV-miR-B5-3p 506 编码膜糖蛋白,在细胞内信号传导中发挥作用/黏液素在上皮表面形成的保护性黏液屏障中起重要作用 It encodes membrane glycoproteins and plays a role in intracellular signaling, and mucin plays an important role in the protective mucus barrier formed by the epithelial surface 16 MUC12 BLV-miR-B5-5p 3373 编码膜糖蛋白,在细胞内信号传导中发挥作用/黏液素在上皮表面形成的保护性黏液屏障中起重要作用 It encodes membrane glycoproteins and plays a role in intracellular signaling, and mucin plays an important role in the protective mucus barrier formed by the epithelial surface