二花脸猪linc-NORFA核心启动子鉴定与转录调控分析
杜星(
),曾强,刘禄,李琦琦,杨柳,潘增祥,李齐发()
),曾强,刘禄,李琦琦,杨柳,潘增祥,李齐发()
Identification of the Core Promoter of Linc-NORFA and Its Transcriptional Regulation in Erhualian Pig
DU Xing(),ZENG Qiang,LIU Lu,LI QiQi,YANG Liu,PAN ZengXiang,LI QiFa()
),ZENG Qiang,LIU Lu,LI QiQi,YANG Liu,PAN ZengXiang,LI QiFa()
图6. FOXO1作为转录因子抑制猪卵巢颗粒细胞中linc-NORFA表达
（A）过表达FOXO1对linc-NORFA表达水平的影响;（B）过表达FOXO1对linc-NORFA核心启动子活性的影响;（C）通过ChIP试验鉴定FOXO1与linc-NORFA核心启动子的结合丰度;（D）双氧水诱导氧化应激对FOXO1表达水平的影响;（E）双氧水诱导氧化应激对linc-NORFA表达水平的影响
Fig. 6. FOXO1 acts as a transcription factor and inhibits linc-NORFA expression in porcine GCs
(A) The effects of FOXO1 overexpression on the expression level of linc-NORFA; (B) The effects of FOXO1 overexpression on the activity of linc-NORFA core promoter; (C) ChIP assay was performed to analyze the enrichment of FOXO1 on the core promoter of linc-NORFA; (D) The effects of H2O2-induced oxidative stress on the expression level of FOXO1;(E) The effects of H2O2-induced oxidative stress on the expression level of linc-NORFA
