蜡样芽孢杆菌致吐毒素的毒性作用与生物合成研究进展

崔一芳,郑敏,丁双阳,朱奎

Advances of Biosynthesis and Toxicity of Cereulide Produced by Emetic Bacillus cereus

CUI YiFang,ZHENG Min,DING ShuangYang,ZHU Kui

图2 NRPS的3种生物合成途径 NRPS系统的A型生物合成途径可合成线性肽,例如枯草芽孢杆菌(B. subtilis)中的表面活性素(surfactin)。B型途径合成迭代肽,典型代表为蜡样芽孢杆菌(B. cereus)的致吐毒素(cereulide)。C型途径控制合成非线性肽,例如霍乱弧菌(Vibrio cholerae)的弧菌杆菌素(vibriobactin)

Fig. 2 Three biosynthesis pathways of NRPSs Type A biosynthesis pathway of NRPS system synthesizes linear peptides, such as surfactin in B. subtilis. Type B pathway synthesizes iterative peptides like cereulide in B. cereus. Type C pathway encodes nonlinear peptides, such as vibriobactin in Vibrio cholerae