蜡样芽孢杆菌致吐毒素的毒性作用与生物合成研究进展

崔一芳,郑敏,丁双阳,朱奎

Advances of Biosynthesis and Toxicity of Cereulide Produced by Emetic Bacillus cereus

CUI YiFang,ZHENG Min,DING ShuangYang,ZHU Kui

图1 Cereulide的毒性及作用机制 A：Cereulide存在于多种食物中,通过与胃肠道内分布的5-HT3受体结合,刺激迷走神经进而引发呕吐症状;B：Cereulide作为钾离子载体,会破坏细胞脂质膜上的电化学电位梯度,通过影响呼吸作用,最终导致细胞死亡

Fig. 1 Toxicity and mechanism of cereulide A: Cereulide is present in a variety of foods. It induces vomiting by binding to 5-HT3 receptors in the gastrointestinal tract and stimulating the vagus nerve; B: Cereulide, as a potassium ionophore, disrupts the electrochemical potential gradient on lipid membranes which affects respiration, and ultimately leads to cell death