藏黄牛与宣汉黄牛心脏miRNA表达谱比较

陈露露,王会,王吉坤,王嘉博,柴志欣,陈智华,钟金城

Comparative Analysis of miRNA Expression Profiles in the Hearts of Tibetan Cattle and Xuanhan Cattle

LuLu CHEN,Hui WANG,JiKun WANG,JiaBo WANG,ZhiXin CHAI,ZhiHua CHEN,JinCheng ZHONG

表5 3个信号通路涉及的靶基因

Table 5 Target genes involved in the three signaling pathways

富集通路 Enrichment pathway 靶基因 Target gene 胰岛素信号通路 Insulin signaling pathway FASN, PYG, GYS, HK, PHKG, PIK3C, G6PC, PCK, ACACB, BAD, CALM, PIK3R, HRAS, RP-S6e, GSK3B, SOS, EIF4E, FBP, PKA, GRB2, BRAF, RAF1, MAP2K1, MAP2K2, MAPK13, MKNK, ELK1, CRK, JNK, AKT,INSR, RPS6KB, SOCS1, SOCS2, SOCS3, SOCS4, CBL, PRKAR, PTPRF, PTPN1, PRKCI, SORBS1, PPP1C, PDPK1, RAPGEF1, SHC1, IRS2, LIPE, PPP1R3, PHKA-B, SLC2A4, FLOT, APS, RHOQ, EXOC7, TRIP10, SREBP1, PRKAA, PRKAB, PRKAG, FOXO1, PPARGC1A, MTOR, RAPTOR, EIF4EBP1, TSC1, TSC2, RHEB, IKBKB, KRAS, NRAS, ARAF, ACACA, PKLR, GCK, PDE3B, SHIP2, IRS1, IRS3, IRS4, SHC2, SHC3, SHC4, PPP1R3F, PRKCZ, HRAS, GSK3B, CXCR4, PPP3C, RASA1, MAPK1_3, RAC1, PAK1, PAK2, RHOA, ROCK1, GNAI, MET, EPHA1, EPHA2, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, EFNA, EFNB, FYN, ITGB1, PTK2, PAK3, PAK4, PAK6, PAK7, LIMK1, LIMK2, CFL, PPP3R, SEMA4, SEMA7, L1CAM, PLXNC, ABL1, NRP1, ROBO1, ROBO2, DCC, PLXNA, PLXNB mTOR信号通路 mTOR signaling pathway PIK3C, PTEN, PIK3R, PRKCA, RP-S6e, TNF, EIF4B, EIF4E, BRAF, MAPK1_3, RPS6KA, AKT, RPS6KB, VEGFA, IGF1, PDPK1, PRKAA, MTOR, RAPTOR, EIF4EBP1, TSC1, TSC2, RHEB, IKBKB, STK11, MLST8, RICTOR, HIF1A, ULK1_2_3, DDIT4, STRADA, CAB39, IRS1, AKT1S1, RRAGA_B, RRAGC_D, PRKCB, PRKCG HIF-1信号通路 HIF-1 signaling pathway GAPDH, PDHA, PDHB, HK, PIK3C, PFKFB3, PLCG1, ENO, BCL2, NFKB1, PIK3R, PRKCA, RP-S6e, TNFRSF3, EIF4E, RBX1, CUL2, VHL, SERPINE1, EGF, EGFR, MAP2K1, MAPK1_3, MKNK, AKT, EP300, CAMK2, INSR, IFNG, RPS6KB, STAT3, RELA, IL6R, ERBB2, IGF1R, FLT1, TEK, IFNGR1, IFNGR2, IL6, EPO, VEGFA, IGF1, ANGPT1, ANGPT2, ANGPT4, PLCG2, TFRC, CDKN1B, CDKN1A, MTOR, EIF4EBP1, SLC2A1, NOX, HIF1A, EGLN, TLR4, PDK1, NOS2, NOS3, TF, EDN1, TIMP1, PRKCB, PRKCG