多杀性巴氏杆菌荚膜的生物合成及其调控机制研究进展

关丽君,薛云,丁文文,赵战勤

Advances in Mechanisms of Biosynthesis and Regulation of Pasteurella multocida Capsule

LiJun GUAN,Yun XUE,WenWen DING,ZhanQin ZHAO

表2 II类荚膜生物合成基因簇及编码蛋白的功能

Table 2 Biosynthesis gene clusters and protein-coding function of class II capsule

功能区 Region 开放阅读框（ORF） B型/E型编码的蛋白质 Protein encoded by type B/E 功能 Function B型 Type B E型 Type F R1 cexA cexA CexA ATP结合蛋白 ATP-binding protein cexB cexB CexB 内膜蛋白 Inner membrane protein cexC cexC CexC 具有周质结构域的内膜蛋白 Inner membrane protein with a periplasmic domain cexD cexD CexD 外膜蛋白 Outer membrane protein R2 bcbA ecbA BcbA/EcbA UDP-N-乙酰葡糖胺2-差向异构酶 UDP-N-acetylglucosamine 2-epimerase bcbB ecbB BcbB/EcbB UDP-N-乙酰-D-甘露糖胺糖醛酸脱氢酶 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase bcbC ecbK BcbC/EcbK 假定的糖基转移酶,可能参与活化单糖的聚合 Putative glycosyltransferase, which likely involved in polymerization of the activated sugar bcbDEFGI ecbDEFGI BcbDEFGI/EcbDEFGI 未知 Unknown bcbH ecbJ BcbH/EcbJ 未知,是B型或E型的独有基因 Unknown, unique to serogroup B or E R3 lipA lipA LipA 参与多糖的磷脂替换 Involved in phospholipid substitution of GAG lipB lipB LipB 参与多糖的磷脂替换 Involved in phospholipid substitution of GAG