微小RNA及其介导的竞争性内源RNA调控网络在意大利蜜蜂工蜂中肠发育过程中的潜在作用

杜宇,范小雪,蒋海宾,王杰,范元婵,祝智威,周丁丁,万洁琦,卢家轩,熊翠玲,郑燕珍,陈大福,郭睿

The Potential Role of MicroRNAs and MicroRNA-Mediated Competing Endogenous Networks During the Developmental Process of Apis mellifera ligustica Worker’s Midgut

DU Yu,FAN XiaoXue,JIANG HaiBin,WANG Jie,FAN YuanChan,ZHU ZhiWei,ZHOU DingDing,WAN JieQi,LU JiaXuan,XIONG CuiLing,ZHENG YanZhen,CHEN DaFu,GUO Rui

表6 意大利蜜蜂工蜂中肠下调miRNA的靶mRNA显著富集的前15位通路

Table 6 Top 15 pathways significantly enriched by target mRNAs of significantly down-regulated miRNAs in the midgut of A. m. ligustica worker

通路 Pathway 通路ID Pathway ID 靶mRNA富集数 Number of target mRNAs P值 P value Hippo信号通路 Hippo signaling pathway ko04390 134 6.20E-17 醛固酮合成与分泌 Aldosterone synthesis and secretion ko04925 78 1.79E-17 胆碱能突触 Cholinergic synapse ko04725 84 1.71E-17 卵母细胞减数分裂 Oocyte meiosis ko04114 103 8.04E-19 昼夜节律调节 Circadian entrainment ko04713 79 3.12E-19 胃酸分泌 Gastric acid secretion ko04971 75 1.66E-19 神经营养因子信号通路 Neurotrophin signaling pathway ko04722 99 1.20E-19 胰岛素分泌 Insulin secretion ko04911 83 9.94E-20 促性腺激素释放激素信号通路 GnRH signaling pathway ko04912 91 9.12E-20 长时程增强 Long-term potentiation ko04720 82 4.72E-20 钙信号通道 Calcium signaling pathway ko04020 101 3.09E-22 ErbB信号通路 ErbB signaling pathway ko04012 87 3.11E-23 cAMP信号通路 cAMP signaling pathway ko04024 134 1.19E-23 炎症介质对TRP通道的调节Inflammatory mediator regulation of TRP channels ko04750 97 9.4E-26 黑色素生成 Melanogenesis ko04916 117 9.23E-28