微小RNA及其介导的竞争性内源RNA调控网络在意大利蜜蜂工蜂中肠发育过程中的潜在作用

杜宇,范小雪,蒋海宾,王杰,范元婵,祝智威,周丁丁,万洁琦,卢家轩,熊翠玲,郑燕珍,陈大福,郭睿

The Potential Role of MicroRNAs and MicroRNA-Mediated Competing Endogenous Networks During the Developmental Process of Apis mellifera ligustica Worker’s Midgut

DU Yu,FAN XiaoXue,JIANG HaiBin,WANG Jie,FAN YuanChan,ZHU ZhiWei,ZHOU DingDing,WAN JieQi,LU JiaXuan,XIONG CuiLing,ZHENG YanZhen,CHEN DaFu,GUO Rui

表5 意蜂工蜂中肠上调miRNA的靶mRNA显著富集的前15位通路

Table 5 Top 15 pathways significantly enriched by target mRNAs of significantly up-regulated miRNAs in the midgut of A. m. ligustica worker

通路 Pathway 通路ID Pathway ID 靶mRNA富集数 Number of target mRNAs P值 P value 钙信号通道 Calcium signaling pathway ko04020 77 1.30E-14 催产素信号通路 Oxytocin signaling pathway ko04921 82 1.07E-14 坏死性凋亡 Necroptosis ko04217 58 5.72E-16 嗅觉传导 Olfactory transduction ko04740 50 3.01E-17 长时程增强 Long-term potentiation ko04720 70 3.98E-18 Hippo信号通路 Hippo signaling pathway ko04390 118 1.29E-18 促性腺激素释放激素信号通路 GnRH signaling pathway ko04912 79 4.76E-19 神经营养因子信号通路 Neurotrophin signaling pathway ko04722 89 3.17E-21 胆碱能突触 Cholinergic synapse ko04725 79 2.90E-21 胃酸分泌 Gastric acid secretion ko04971 69 2.05E-21 醛固酮合成与分泌 Aldosterone synthesis and secretion ko04925 74 1.94E-21 cAMP信号通路 cAMP signaling pathway ko04024 113 1.73E-21 昼夜节律调节 Circadian entrainment ko04713 75 2.93E-23 胰岛素分泌 Insulin secretion ko04911 78 2.53E-23 ErbB信号通路 ErbB signaling pathway ko04012 80 2.43E-25