液相色谱-串联质谱法同时测定饲用血液制品中 18种β-受体激动剂
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索德成,魏书林,肖志明,王培龙,王瑞国,李阳
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Simultaneous Determination of 18 β-agonists in Blood Products for Feeds by Liquid Chromatography Tandem Mass Spectrometry
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DeCheng SUO,ShuLin WEI,ZhiMing XIAO,PeiLong WANG,RuiGuo WANG,Yang LI
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表2 β-受体激动剂的定性、定量离子对及锥孔电压、碰撞电压的参考值
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Table 2 MRM optimization conditions of β-agonists
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药物名称
Drug | 定性离子对
Qualitative ion pair (m/z) | 定量离子对
Quantitative ion pair (m/z) | 锥孔电压
Cove (V) | 碰撞能量
CE (eV) | | 西马特罗Cimaterol | 220.1＞202.1 | 220.1＞202.1 | 16 | 10 | | 220.1＞160.1 | 16 | | 马布特罗Mabuterol | 310.9＞237.1 | 310.9＞216.9 | 26 | 16 | | 310.9＞216.9 | 25 | | 西布特罗Cimbuterol | 234.2＞162.0 | 234.2＞162.0 | 23 | 16 | | 234.2＞216.2 | 10 | | 溴布特罗Brombuterol | 367.0＞293.0 | 367.0＞293.0 | 25 | 19 | | 367.0＞349.0 | 12 | | 莱克多巴胺Ractopamine | 302.2＞163.9 | 302.4＞163.9 | 26 | 17 | | 302.2＞284.4 | 13 | | 氯丙那林Clorprenaline | 213.9＞153.9 | 213.9＞153.9 | 25 | 17 | | 213.9＞196.1 | 12 | | 特布他林Terbutaline | 226.3＞152.3 | 226.3＞152.3 | 25 | 17 | | 226.3＞170.3 | 12 | | 齐帕特罗Zilpaterol | 263.1＞245.3 | 263.1＞245.2 | 24 | 13 | | 263.1＞185.3 | 24 | | 沙丁胺醇Salbutamol | 240.0＞148.3 | 240.3＞148.3 | 22 | 20 | | 240.0＞222.3 | 10 | | 克仑特罗Clenbuterol | 277.0＞203.0 | 277.0＞203.0 | 25 | 17 | | 277.0＞259.0 | 11 | | 克仑普罗Clenproperol | 262.8＞244.9 | 262.8＞202.8 | 19 | 14 | | 262.8＞202.8 | 16 | | 妥布特罗Tulobuterol | 228.0＞153.7 | 228.0＞154.0 | 19 | 14 | | 228.0＞171.7 | 9 | | 班布特罗Bambuterol | 368.0＞71.7 | 368.0＞294.0 | 25 | 30 | | 368.0＞294.0 | 17 | | 苯乙醇胺A Phenylethanolamine A | 345.1＞150.0 | 345.1＞150.0 | 22 | 30 | | 345.1＞327.0 | 17 | | 福莫特罗Formoterol | 345.0＞149.0 | 345.0＞149.0 | 22 | 30 | | 345.0＞327.0 | 17 | | 利托君Ritodrine | 288.2＞270.1 | 288.2＞121 | 20 | 12 | | 288.2＞121 | 24 | | 克伦塞罗Clencyclohexerol | 319.1＞202.9 | 319.1＞202.9 | 22 | 20 | | 319.1＞301.1 | 13 | | 沙美特罗Salmeterol | 416.2＞380.3 | 416.2＞398.3 | 30 | `18 | | 416.2＞398.3 | 15 |
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