苏博美利奴羊毛囊发育相关lncRNA与mRNA共表达网络的构建

陈华峰,田可川,黄锡霞,阿布来提·苏来曼,何军敏,田月珍,徐新明,付雪峰,赵冰茹,朱桦,哈尼克孜·吐拉甫

Construction of Co-expression Network of lncRNA and mRNA Related to Hair Follicle Development of Subo Merino Sheep

HuaFeng CHEN,KeChuan TIAN,XiXia HUANG,Sulayman Ablat,JunMin HE,YueZhen TIAN,XinMing XU,XueFeng FU,BingRu ZHAO,Hua ZHU,Tulafu Hanikezi

表4 目标模块部分KEGG富集结果

Table 4 Part KEGG enrichment results of the target modules

模块 Module ID KEGG条目 KEGG Term 基因数 No. genes P值 P value 基因 Genes honeydew1 oas04512 ECM-受体相互作用 ECM-receptor interaction 6 2.30E-02 LAMA1, ITGA11, COL2A1, THBS2, COL5A2, COL5A1 oas04510 粘着力 Focal adhesion 11 4.72E-03 LAMA1, TLN2, PGF, ITGA11, PIK3R5, COL2A1, HGF, PIK3R3, THBS2, COL5A2, COL5A1 oas04340 Hedgehog信号通路 Hedgehog signaling pathway 5 1.11E-03 PTCH1, PTCH2, HHIP, GLI2, GLI1 paleturquoise oas04530 紧密连接 Tight junction 14 1.63E-02 CLDN8, PPP2R1B, PARD6B, CLDN4, MYL10, CLDN10, CLDN14, LLGL2, EPB41L3, IGSF5, CLDN1, MYH14, TJP3, MYH7B oas04010 MAPK信号通路 MAPK signaling pathway 24 4.05E-03 IL1R2, FGF5, MAPKAPK3, TGFB3, NR4A1, FGF22, FGF21, FGF12, FLNC, CACNA2D3, DUSP4, MAP3K6, FOS, MAP3K5, DUSP2, HSPA2, DUSP1, MAPK13, RPS6KA2, HSPB1, GADD45B, PLA2G4E, CD14, NGF skyblue2 oas04512 ECM-受体相互作用 ECM-receptor interaction 18 6.93E-10 COL4A4, COL4A3, TNC, ITGA3, COL5A3, ITGA9, LAMB3, COL6A6, LAMC3, LAMA5, COL6A5, ITGB6, RELN, SV2A, THBS1, COL24A1, SPP1, FN1 oas04310 Wnt信号通路 Wnt signaling pathway 9 4.50E-02 WNT2, WNT10A, WNT4, WNT5B, DKK1, SFRP4, MMP7, FZD1, WIF1